ID IRAK2_BOVIN Reviewed; 621 AA. AC Q0P5I2; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 19-SEP-2006, sequence version 1. DT 12-AUG-2020, entry version 97. DE RecName: Full=Interleukin-1 receptor-associated kinase-like 2; DE Short=IRAK-2; GN Name=IRAK2; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Fetal liver; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to the IL-1 type I receptor following IL-1 engagement, CC triggering intracellular signaling cascades leading to transcriptional CC up-regulation and mRNA stabilization. {ECO:0000250}. CC -!- SUBUNIT: Interacts with MYD88. IL-1 stimulation leads to the formation CC of a signaling complex which dissociates from the IL-1 receptor CC following the binding of PELI1 (By similarity). {ECO:0000250}. CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically CC inactive. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr CC protein kinase family. Pelle subfamily. {ECO:0000305}. CC -!- CAUTION: Asn-331 is present instead of the conserved Asp which is CC expected to be an active site residue. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC120001; AAI20002.1; -; mRNA. DR RefSeq; NP_001069164.1; NM_001075696.2. DR SMR; Q0P5I2; -. DR STRING; 9913.ENSBTAP00000008135; -. DR PaxDb; Q0P5I2; -. DR PRIDE; Q0P5I2; -. DR Ensembl; ENSBTAT00000008135; ENSBTAP00000008135; ENSBTAG00000006193. DR GeneID; 515034; -. DR KEGG; bta:515034; -. DR CTD; 3656; -. DR VGNC; VGNC:30266; IRAK2. DR eggNOG; KOG1187; Eukaryota. DR GeneTree; ENSGT00940000159835; -. DR InParanoid; Q0P5I2; -. DR KO; K04731; -. DR OMA; IKVMNYR; -. DR OrthoDB; 684563at2759; -. DR TreeFam; TF328924; -. DR Reactome; R-BTA-168638; NOD1/2 Signaling Pathway. DR Reactome; R-BTA-445989; TAK1 activates NFkB by phosphorylation and activation of IKKs complex. DR Reactome; R-BTA-450302; activated TAK1 mediates p38 MAPK activation. DR Reactome; R-BTA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1. DR Reactome; R-BTA-9020702; Interleukin-1 signaling. DR Reactome; R-BTA-937042; IRAK2 mediated activation of TAK1 complex. DR Reactome; R-BTA-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex. DR Reactome; R-BTA-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. DR Reactome; R-BTA-975155; MyD88 dependent cascade initiated on endosome. DR Reactome; R-BTA-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation. DR Proteomes; UP000009136; Chromosome 22. DR Bgee; ENSBTAG00000006193; Expressed in skeletal muscle tissue and 19 other tissues. DR ExpressionAtlas; Q0P5I2; baseline. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central. DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IBA:GO_Central. DR GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; IEA:Ensembl. DR CDD; cd08795; Death_IRAK2; 1. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR000488; Death_domain. DR InterPro; IPR042151; Death_IRAK2. DR InterPro; IPR033611; IRAK2. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR PANTHER; PTHR24419:SF2; PTHR24419:SF2; 1. DR Pfam; PF00531; Death; 1. DR Pfam; PF00069; Pkinase; 1. DR SUPFAM; SSF47986; SSF47986; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. PE 2: Evidence at transcript level; KW ATP-binding; Nucleotide-binding; Reference proteome. FT CHAIN 1..621 FT /note="Interleukin-1 receptor-associated kinase-like 2" FT /id="PRO_0000277559" FT DOMAIN 13..94 FT /note="Death" FT DOMAIN 206..476 FT /note="Protein kinase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT NP_BIND 212..220 FT /note="ATP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT NP_BIND 333..336 FT /note="ATP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 233 FT /note="ATP" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" SQ SEQUENCE 621 AA; 68630 MW; 8641DDD096BD993F CRC64; MSCYIYQLPS WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER AQGVSITREL LWWWGMRQAT VQQLLDLLCH LELYRAAQII LNWKPVLEVK SSIPDFSDTV KPGKPLAASV RNTEDKQETG QPVRPPTFPG SGPAAVRVNL PAPPEDASSS LKTNQTASAD SKDFSASIPK QETLSSLAGD DLFWSEVDVI QATDNFNPSH KISEGTFADV YRGHKRGTPF IFKKLREMAC SGPGSVEKFF QAEVQICRRC CHPNVLPLLG CCTGEQFYSL IYPYMANGSL QDRLQGQGGS DPLPWPQRIS ICSGLLHAVE HLHSLEIIHG NVKSSNVLLD QNFTPKLAHS MAHPCPVNRT SKYTMMKTHL FQASTAYLPE DFIRVGQLTK RVDIFSCGIV LAEVLTGIPA MDNNRNPVYL KDLLLHEIPS STISLCSRKM GVEKEMAKEI CQKYLEKRAG RLPEAHAEAL VMAACLCLRR RNASLAEVCS SVAAVEEQLR GQETSLPCSG LSEGTGSSFN TPEETDDVDN SSFDGSYSMR AAPWAGATSS PPLTADEEGM LLAGGAVEAD SSAEACAPPE PPQDATETSW KIEINEAKRK LMENILLYKE EKLDSIELFG P //