ID IRAK2_BOVIN Reviewed; 621 AA. AC Q0P5I2; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 19-SEP-2006, sequence version 1. DT 11-JUL-2012, entry version 46. DE RecName: Full=Interleukin-1 receptor-associated kinase-like 2; DE Short=IRAK-2; GN Name=IRAK2; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Fetal liver; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to the IL-1 type I receptor following IL-1 CC engagement, triggering intracellular signaling cascades leading to CC transcriptional up-regulation and mRNA stabilization (By CC similarity). CC -!- SUBUNIT: Interacts with MYD88. IL-1 stimulation leads to the CC formation of a signaling complex which dissociates from the IL-1 CC receptor following the binding of PELI1 (By similarity). CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically CC inactive. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr CC protein kinase family. Pelle subfamily. CC -!- SIMILARITY: Contains 1 death domain. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC -!- CAUTION: Asn-331 is present instead of the conserved Asp which is CC expected to be an active site residue. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC120001; AAI20002.1; -; mRNA. DR IPI; IPI00705963; -. DR RefSeq; NP_001069164.1; NM_001075696.1. DR UniGene; Bt.76138; -. DR ProteinModelPortal; Q0P5I2; -. DR STRING; Q0P5I2; -. DR PRIDE; Q0P5I2; -. DR Ensembl; ENSBTAT00000008135; ENSBTAP00000008135; ENSBTAG00000006193. DR GeneID; 515034; -. DR KEGG; bta:515034; -. DR CTD; 3656; -. DR eggNOG; COG0515; -. DR GeneTree; ENSGT00530000063073; -. DR HOGENOM; HOG000113102; -. DR HOVERGEN; HBG052145; -. DR InParanoid; Q0P5I2; -. DR KO; K04731; -. DR OMA; THLFQAS; -. DR OrthoDB; EOG4R23TT; -. DR NextBio; 20871637; -. DR GO; GO:0009986; C:cell surface; IEA:Compara. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro. DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IEA:Compara. DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara. DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara. DR GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; IEA:Compara. DR Gene3D; G3DSA:1.10.533.10; DEATH_like; 1. DR InterPro; IPR000488; Death. DR InterPro; IPR011029; DEATH-like. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_cat_dom. DR Pfam; PF00531; Death; 1. DR Pfam; PF00069; Pkinase; 1. DR SUPFAM; SSF47986; DEATH_like; 1. DR SUPFAM; SSF56112; Kinase_like; 1. DR PROSITE; PS50017; DEATH_DOMAIN; FALSE_NEG. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; FALSE_NEG. PE 2: Evidence at transcript level; KW ATP-binding; Complete proteome; Nucleotide-binding; Phosphoprotein; KW Reference proteome. FT CHAIN 1 621 Interleukin-1 receptor-associated kinase- FT like 2. FT /FTId=PRO_0000277559. FT DOMAIN 13 94 Death. FT DOMAIN 206 476 Protein kinase. FT NP_BIND 212 220 ATP (By similarity). FT NP_BIND 333 336 ATP (By similarity). FT BINDING 233 233 ATP (By similarity). FT MOD_RES 364 364 Phosphothreonine (By similarity). SQ SEQUENCE 621 AA; 68630 MW; 8641DDD096BD993F CRC64; MSCYIYQLPS WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER AQGVSITREL LWWWGMRQAT VQQLLDLLCH LELYRAAQII LNWKPVLEVK SSIPDFSDTV KPGKPLAASV RNTEDKQETG QPVRPPTFPG SGPAAVRVNL PAPPEDASSS LKTNQTASAD SKDFSASIPK QETLSSLAGD DLFWSEVDVI QATDNFNPSH KISEGTFADV YRGHKRGTPF IFKKLREMAC SGPGSVEKFF QAEVQICRRC CHPNVLPLLG CCTGEQFYSL IYPYMANGSL QDRLQGQGGS DPLPWPQRIS ICSGLLHAVE HLHSLEIIHG NVKSSNVLLD QNFTPKLAHS MAHPCPVNRT SKYTMMKTHL FQASTAYLPE DFIRVGQLTK RVDIFSCGIV LAEVLTGIPA MDNNRNPVYL KDLLLHEIPS STISLCSRKM GVEKEMAKEI CQKYLEKRAG RLPEAHAEAL VMAACLCLRR RNASLAEVCS SVAAVEEQLR GQETSLPCSG LSEGTGSSFN TPEETDDVDN SSFDGSYSMR AAPWAGATSS PPLTADEEGM LLAGGAVEAD SSAEACAPPE PPQDATETSW KIEINEAKRK LMENILLYKE EKLDSIELFG P //