ID IRAK2_BOVIN Reviewed; 621 AA. AC Q0P5I2; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 19-SEP-2006, sequence version 1. DT 24-JAN-2024, entry version 112. DE RecName: Full=Interleukin-1 receptor-associated kinase-like 2; DE Short=IRAK-2; GN Name=IRAK2; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford; TISSUE=Fetal liver; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to the IL-1 type I receptor following IL-1 engagement, CC triggering intracellular signaling cascades leading to transcriptional CC up-regulation and mRNA stabilization. {ECO:0000250}. CC -!- SUBUNIT: Interacts with MYD88. IL-1 stimulation leads to the formation CC of a signaling complex which dissociates from the IL-1 receptor CC following the binding of PELI1 (By similarity). {ECO:0000250}. CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically CC inactive. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr CC protein kinase family. Pelle subfamily. {ECO:0000305}. CC -!- CAUTION: Asn-331 is present instead of the conserved Asp which is CC expected to be an active site residue. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC120001; AAI20002.1; -; mRNA. DR RefSeq; NP_001069164.1; NM_001075696.2. DR AlphaFoldDB; Q0P5I2; -. DR SMR; Q0P5I2; -. DR STRING; 9913.ENSBTAP00000008135; -. DR PaxDb; 9913-ENSBTAP00000008135; -. DR Ensembl; ENSBTAT00000008135.6; ENSBTAP00000008135.5; ENSBTAG00000006193.6. DR GeneID; 515034; -. DR KEGG; bta:515034; -. DR CTD; 3656; -. DR VEuPathDB; HostDB:ENSBTAG00000006193; -. DR VGNC; VGNC:30266; IRAK2. DR eggNOG; KOG1187; Eukaryota. DR GeneTree; ENSGT00940000159835; -. DR InParanoid; Q0P5I2; -. DR OMA; ALSEWDW; -. DR OrthoDB; 2999496at2759; -. DR TreeFam; TF328924; -. DR Reactome; R-BTA-450302; activated TAK1 mediates p38 MAPK activation. DR Reactome; R-BTA-450321; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1. DR Reactome; R-BTA-9020702; Interleukin-1 signaling. DR Reactome; R-BTA-937042; IRAK2 mediated activation of TAK1 complex. DR Reactome; R-BTA-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex. DR Reactome; R-BTA-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation. DR Proteomes; UP000009136; Chromosome 22. DR Bgee; ENSBTAG00000006193; Expressed in choroid plexus and 103 other cell types or tissues. DR ExpressionAtlas; Q0P5I2; baseline. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro. DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central. DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central. DR GO; GO:0008063; P:Toll signaling pathway; IBA:GO_Central. DR CDD; cd08795; Death_IRAK2; 1. DR Gene3D; 1.10.533.10; Death Domain, Fas; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR000488; Death_domain. DR InterPro; IPR042151; Death_IRAK2. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR PANTHER; PTHR24419; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE; 1. DR PANTHER; PTHR24419:SF2; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-LIKE 2; 1. DR Pfam; PF00531; Death; 1. DR Pfam; PF00069; Pkinase; 1. DR SUPFAM; SSF47986; DEATH domain; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. PE 2: Evidence at transcript level; KW ATP-binding; Nucleotide-binding; Reference proteome. FT CHAIN 1..621 FT /note="Interleukin-1 receptor-associated kinase-like 2" FT /id="PRO_0000277559" FT DOMAIN 13..94 FT /note="Death" FT DOMAIN 206..476 FT /note="Protein kinase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT REGION 113..175 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 503..534 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 156..175 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 212..220 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 233 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 333..336 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" SQ SEQUENCE 621 AA; 68630 MW; 8641DDD096BD993F CRC64; MSCYIYQLPS WVLDDLCRNM DTLSEWDWMQ FASYVITDLT QLRKIKSMER AQGVSITREL LWWWGMRQAT VQQLLDLLCH LELYRAAQII LNWKPVLEVK SSIPDFSDTV KPGKPLAASV RNTEDKQETG QPVRPPTFPG SGPAAVRVNL PAPPEDASSS LKTNQTASAD SKDFSASIPK QETLSSLAGD DLFWSEVDVI QATDNFNPSH KISEGTFADV YRGHKRGTPF IFKKLREMAC SGPGSVEKFF QAEVQICRRC CHPNVLPLLG CCTGEQFYSL IYPYMANGSL QDRLQGQGGS DPLPWPQRIS ICSGLLHAVE HLHSLEIIHG NVKSSNVLLD QNFTPKLAHS MAHPCPVNRT SKYTMMKTHL FQASTAYLPE DFIRVGQLTK RVDIFSCGIV LAEVLTGIPA MDNNRNPVYL KDLLLHEIPS STISLCSRKM GVEKEMAKEI CQKYLEKRAG RLPEAHAEAL VMAACLCLRR RNASLAEVCS SVAAVEEQLR GQETSLPCSG LSEGTGSSFN TPEETDDVDN SSFDGSYSMR AAPWAGATSS PPLTADEEGM LLAGGAVEAD SSAEACAPPE PPQDATETSW KIEINEAKRK LMENILLYKE EKLDSIELFG P //