ID Q0MS44_PIG Unreviewed; 467 AA. AC Q0MS44; DT 19-SEP-2006, integrated into UniProtKB/TrEMBL. DT 19-SEP-2006, sequence version 1. DT 16-JAN-2019, entry version 58. DE RecName: Full=Presenilin {ECO:0000256|RuleBase:RU361148}; DE EC=3.4.23.- {ECO:0000256|RuleBase:RU361148}; GN Name=PSEN1 {ECO:0000313|EMBL:ABI15723.1}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ABI15723.1}; RN [1] {ECO:0000313|EMBL:ABI15723.1} RP NUCLEOTIDE SEQUENCE. RA Madsen L.B., Thomsen B., Larsen K., Fredholm M., Joergensen A.L., RA Holm I.E., Nielsen A.L., Bendixen C.; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Probable subunit of the gamma-secretase complex, an CC endoprotease complex that catalyzes the intramembrane cleavage of CC integral membrane proteins such as Notch receptors. CC {ECO:0000256|RuleBase:RU361148}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU361148}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU361148}. Golgi apparatus membrane CC {ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU361148}. CC -!- DOMAIN: The PAL motif is required for normal active site CC conformation. {ECO:0000256|RuleBase:RU361148}. CC -!- SIMILARITY: Belongs to the peptidase A22A family. CC {ECO:0000256|RuleBase:RU361148}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ853416; ABI15723.1; -; mRNA. DR RefSeq; NP_001072135.1; NM_001078667.1. DR UniGene; Ssc.24672; -. DR MEROPS; A22.001; -. DR GeneID; 780411; -. DR KEGG; ssc:780411; -. DR CTD; 5663; -. DR eggNOG; KOG2736; Eukaryota. DR eggNOG; ENOG410XPZD; LUCA. DR HOGENOM; HOG000240228; -. DR HOVERGEN; HBG011375; -. DR KO; K04505; -. DR OrthoDB; 797738at2759; -. DR ChiTaRS; PSEN1; pig. DR Genevisible; Q0MS44; SS. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro. DR GO; GO:0042987; P:amyloid precursor protein catabolic process; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW. DR GO; GO:0016485; P:protein processing; IEA:InterPro. DR InterPro; IPR002031; Pept_A22A_PS1. DR InterPro; IPR001108; Peptidase_A22A. DR InterPro; IPR006639; Preselin/SPP. DR PANTHER; PTHR10202; PTHR10202; 1. DR Pfam; PF01080; Presenilin; 1. DR PRINTS; PR01072; PRESENILIN. DR PRINTS; PR01073; PRESENILIN1. DR SMART; SM00730; PSN; 1. PE 2: Evidence at transcript level; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU361148}; KW Golgi apparatus {ECO:0000256|RuleBase:RU361148}; KW Hydrolase {ECO:0000256|RuleBase:RU361148}; KW Membrane {ECO:0000256|RuleBase:RU361148, KW ECO:0000256|SAAS:SAAS00075475}; KW Notch signaling pathway {ECO:0000256|RuleBase:RU361148}; KW Protease {ECO:0000256|RuleBase:RU361148}; KW Transmembrane {ECO:0000256|RuleBase:RU361148, KW ECO:0000256|SAAS:SAAS00454266}; KW Transmembrane helix {ECO:0000256|RuleBase:RU361148, KW ECO:0000256|SAAS:SAAS00075488}. FT TRANSMEM 83 101 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 134 155 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 162 184 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 196 214 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 226 242 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 248 269 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 408 428 Helical. {ECO:0000256|RuleBase:RU361148}. FT TRANSMEM 434 453 Helical. {ECO:0000256|RuleBase:RU361148}. SQ SEQUENCE 467 AA; 52412 MW; 2A4007CA65A097FA CRC64; MTELPAPLSY FQNAQMSEDN HVSNNVSSQN DSRERHEHSI ERRRRGNSES LSNGGAQGNS RQVVEQEEEE DEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTRK DGQLIYTPFT EDTETVGQRA LHSILNAAIM ISVIVVMTIL LVVLYKYRCY KVIHAWLIIS SLLLLFFFSF IYLGEVFKTY NVAMDYITVA LLIWNFGVVG MIAIHWKGPL RLQQAYLIMI SALMALVFIK YLPEWTAWLI LAVISVYDLV AVLCPNGPLR LLVETAQERN ETLFPALIYS STMVWLVNMA EGDPEAQRKV SKNSNYNAQS TGESQDSVTE SDDGGFSEEW EAQRDSRLGP HHSTAESRSA VQDLSRSIPA TEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI //