ID Q0MS44_PIG Unreviewed; 467 AA. AC Q0MS44; DT 19-SEP-2006, integrated into UniProtKB/TrEMBL. DT 19-SEP-2006, sequence version 1. DT 03-SEP-2014, entry version 38. DE RecName: Full=Presenilin; DE EC=3.4.23.-; GN Name=PSEN1; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823; RN [1] RP NUCLEOTIDE SEQUENCE. RA Madsen L.B., Thomsen B., Larsen K., Fredholm M., Joergensen A.L., RA Holm I.E., Nielsen A.L., Bendixen C.; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Probable subunit of the gamma-secretase complex, an CC endoprotease complex that catalyzes the intramembrane cleavage of CC integral membrane proteins such as Notch receptors (By CC similarity). CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass CC membrane protein (By similarity). CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass CC membrane protein (By similarity). CC -!- DOMAIN: The PAL motif is required for normal active site CC conformation (By similarity). CC -!- SIMILARITY: Belongs to the peptidase A22A family. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ853416; ABI15723.1; -; mRNA. DR RefSeq; NP_001072135.1; NM_001078667.1. DR UniGene; Ssc.24672; -. DR MEROPS; A22.001; -. DR GeneID; 780411; -. DR KEGG; ssc:780411; -. DR CTD; 5663; -. DR HOGENOM; HOG000240228; -. DR HOVERGEN; HBG011375; -. DR KO; K04505; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR InterPro; IPR002031; Pept_A22A_PS1. DR InterPro; IPR001108; Peptidase_A22A. DR InterPro; IPR006639; Preselin/SPP. DR PANTHER; PTHR10202; PTHR10202; 1. DR PANTHER; PTHR10202:SF7; PTHR10202:SF7; 1. DR Pfam; PF01080; Presenilin; 1. DR PRINTS; PR01072; PRESENILIN. DR PRINTS; PR01073; PRESENILIN1. DR SMART; SM00730; PSN; 1. PE 2: Evidence at transcript level; KW Endoplasmic reticulum; Golgi apparatus; Hydrolase; Membrane; KW Notch signaling pathway; Protease; Transmembrane; Transmembrane helix. SQ SEQUENCE 467 AA; 52412 MW; 2A4007CA65A097FA CRC64; MTELPAPLSY FQNAQMSEDN HVSNNVSSQN DSRERHEHSI ERRRRGNSES LSNGGAQGNS RQVVEQEEEE DEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTRK DGQLIYTPFT EDTETVGQRA LHSILNAAIM ISVIVVMTIL LVVLYKYRCY KVIHAWLIIS SLLLLFFFSF IYLGEVFKTY NVAMDYITVA LLIWNFGVVG MIAIHWKGPL RLQQAYLIMI SALMALVFIK YLPEWTAWLI LAVISVYDLV AVLCPNGPLR LLVETAQERN ETLFPALIYS STMVWLVNMA EGDPEAQRKV SKNSNYNAQS TGESQDSVTE SDDGGFSEEW EAQRDSRLGP HHSTAESRSA VQDLSRSIPA TEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI //