ID Q0MS44_PIG Unreviewed; 467 AA. AC Q0MS44; DT 19-SEP-2006, integrated into UniProtKB/TrEMBL. DT 19-SEP-2006, sequence version 1. DT 19-JAN-2010, entry version 17. DE SubName: Full=Presenilin 1; GN Name=PSEN1; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; OC Sus. OX NCBI_TaxID=9823; RN [1] RP NUCLEOTIDE SEQUENCE. RA Madsen L.B., Thomsen B., Larsen K., Fredholm M., Joergensen A.L., RA Holm I.E., Nielsen A.L., Bendixen C.; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ853416; ABI15723.1; -; mRNA. DR RefSeq; NP_001072135.1; -. DR UniGene; Ssc.24672; -. DR MEROPS; A22.001; -. DR Ensembl; ENSSSCT00000002603; ENSSSCP00000002538; ENSSSCG00000002340; Sus scrofa. DR GeneID; 780411; -. DR KEGG; ssc:780411; -. DR CTD; 780411; -. DR HOVERGEN; Q0MS44; -. DR GO; GO:0030424; C:axon; IEA:Compara. DR GO; GO:0043025; C:cell soma; IEA:Compara. DR GO; GO:0035253; C:ciliary rootlet; IEA:Compara. DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Compara. DR GO; GO:0043198; C:dendritic shaft; IEA:Compara. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Compara. DR GO; GO:0005794; C:Golgi apparatus; IEA:Compara. DR GO; GO:0030426; C:growth cone; IEA:Compara. DR GO; GO:0005887; C:integral to plasma membrane; IEA:Compara. DR GO; GO:0005624; C:membrane fraction; IEA:Compara. DR GO; GO:0005739; C:mitochondrion; IEA:Compara. DR GO; GO:0005640; C:nuclear outer membrane; IEA:Compara. DR GO; GO:0008013; F:beta-catenin binding; IEA:Compara. DR GO; GO:0045296; F:cadherin binding; IEA:Compara. DR GO; GO:0004175; F:endopeptidase activity; IEA:Compara. DR GO; GO:0030165; F:PDZ domain binding; IEA:Compara. DR GO; GO:0000186; P:activation of MAPKK activity; IEA:Compara. DR GO; GO:0042987; P:amyloid precursor protein catabolic process; IEA:Compara. DR GO; GO:0042640; P:anagen; IEA:Compara. DR GO; GO:0000045; P:autophagic vacuole formation; IEA:Compara. DR GO; GO:0050435; P:beta-amyloid metabolic process; IEA:Compara. DR GO; GO:0001568; P:blood vessel development; IEA:Compara. DR GO; GO:0048854; P:brain morphogenesis; IEA:Compara. DR GO; GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Compara. DR GO; GO:0001708; P:cell fate specification; IEA:Compara. DR GO; GO:0016337; P:cell-cell adhesion; IEA:Compara. DR GO; GO:0021795; P:cerebral cortex cell migration; IEA:Compara. DR GO; GO:0015871; P:choline transport; IEA:Compara. DR GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Compara. DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Compara. DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Compara. DR GO; GO:0001947; P:heart looping; IEA:Compara. DR GO; GO:0002244; P:hemopoietic progenitor cell differentiation; IEA:Compara. DR GO; GO:0015813; P:L-glutamate transport; IEA:Compara. DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:Compara. DR GO; GO:0007613; P:memory; IEA:Compara. DR GO; GO:0006839; P:mitochondrial transport; IEA:Compara. DR GO; GO:0002573; P:myeloid leukocyte differentiation; IEA:Compara. DR GO; GO:0050771; P:negative regulation of axonogenesis; IEA:Compara. DR GO; GO:0001933; P:negative regulation of protein amino acid p...; IEA:Compara. DR GO; GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara. DR GO; GO:0051402; P:neuron apoptosis; IEA:Compara. DR GO; GO:0048666; P:neuron development; IEA:Compara. DR GO; GO:0001764; P:neuron migration; IEA:Compara. DR GO; GO:0007220; P:Notch receptor processing; IEA:Compara. DR GO; GO:0043065; P:positive regulation of apoptosis; IEA:Compara. DR GO; GO:0050820; P:positive regulation of coagulation; IEA:Compara. DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara. DR GO; GO:0001934; P:positive regulation of protein amino acid p...; IEA:Compara. DR GO; GO:0009791; P:post-embryonic development; IEA:Compara. DR GO; GO:0006486; P:protein amino acid glycosylation; IEA:Compara. DR GO; GO:0015031; P:protein transport; IEA:Compara. DR GO; GO:0007176; P:regulation of epidermal growth factor recep...; IEA:Compara. DR GO; GO:0043393; P:regulation of protein binding; IEA:Compara. DR GO; GO:0060075; P:regulation of resting membrane potential; IEA:Compara. DR GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Compara. DR GO; GO:0051966; P:regulation of synaptic transmission, glutam...; IEA:Compara. DR GO; GO:0006974; P:response to DNA damage stimulus; IEA:Compara. DR GO; GO:0006979; P:response to oxidative stress; IEA:Compara. DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Compara. DR GO; GO:0051563; P:smooth endoplasmic reticulum calcium ion ho...; IEA:Compara. DR GO; GO:0001756; P:somitogenesis; IEA:Compara. DR GO; GO:0016080; P:synaptic vesicle targeting; IEA:Compara. DR GO; GO:0002286; P:T cell activation during immune response; IEA:Compara. DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Compara. DR GO; GO:0048538; P:thymus development; IEA:Compara. DR InterPro; IPR002031; Pept_A22A_PS1. DR InterPro; IPR006639; Peptidase_A22. DR InterPro; IPR001108; Peptidase_A22A. DR PANTHER; PTHR10202:SF7; Pept_A22A_PS1; 1. DR PANTHER; PTHR10202; Peptidase_A22A; 1. DR Pfam; PF01080; Presenilin; 1. DR PRINTS; PR01072; PRESENILIN. DR PRINTS; PR01073; PRESENILIN1. DR SMART; SM00730; PSN; 1. PE 2: Evidence at transcript level; SQ SEQUENCE 467 AA; 52412 MW; 2A4007CA65A097FA CRC64; MTELPAPLSY FQNAQMSEDN HVSNNVSSQN DSRERHEHSI ERRRRGNSES LSNGGAQGNS RQVVEQEEEE DEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTRK DGQLIYTPFT EDTETVGQRA LHSILNAAIM ISVIVVMTIL LVVLYKYRCY KVIHAWLIIS SLLLLFFFSF IYLGEVFKTY NVAMDYITVA LLIWNFGVVG MIAIHWKGPL RLQQAYLIMI SALMALVFIK YLPEWTAWLI LAVISVYDLV AVLCPNGPLR LLVETAQERN ETLFPALIYS STMVWLVNMA EGDPEAQRKV SKNSNYNAQS TGESQDSVTE SDDGGFSEEW EAQRDSRLGP HHSTAESRSA VQDLSRSIPA TEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI //