ID   Q0GYP4_SPAAU            Unreviewed;       241 AA.
AC   Q0GYP4;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   12-AUG-2020, entry version 52.
DE   SubName: Full=Trypsinogen II {ECO:0000313|EMBL:ABE68639.1};
DE            EC=3.4.21.4 {ECO:0000313|EMBL:ABE68639.1};
GN   Name=TRPII {ECO:0000313|EMBL:ABE68639.1};
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175 {ECO:0000313|EMBL:ABE68639.1};
RN   [1] {ECO:0000313|EMBL:ABE68639.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:ABE68639.1};
RA   Psohiou E., Sarropoulou E., Mamuris Z., Moutou K.A.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABE68639.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Liver {ECO:0000313|EMBL:ABE68639.1};
RX   PubMed=17341447; DOI=10.1016/j.cbpb.2007.01.020;
RA   Psochiou E., Sarropoulou E., Mamuris Z., Moutou K.A.;
RT   "Sequence analysis and tissue expression pattern of Sparus aurata
RT   chymotrypsinogens and trypsinogen.";
RL   Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 147:367-377(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
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DR   EMBL; DQ443543; ABE68639.1; -; mRNA.
DR   MEROPS; S01.125; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; -; 3.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:ABE68639.1};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..241
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012836321"
FT   DOMAIN          21..239
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   241 AA;  26258 MW;  A16A7AFF71CDE151 CRC64;
     MKCLVFVLLI GAAFALDDDK IVGGYECQAH SQPHQVSLNS GYHFCGGSLV NENWVVSAAH
     CYKSRVEVRL GEHDIYRNEG TEQFISSSRV IRHPNYNSWN IDNDIMLIKL SKPATLNSYV
     QPVALPTSCA PAGTMCRVSG WGNTMSSVSG DQLQCLEIPI LSTRDCENSY PGMITDAMFC
     AGYLEGGKDS CQGDSGGPVV CNGQLQGVVS WGYGCAERDH PGVYAKVCIF NDWLETTMAS
     Y
//