ID Q0E8S4_DROME Unreviewed; 905 AA. AC Q0E8S4; DT 17-OCT-2006, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 11-NOV-2015, entry version 85. DE SubName: Full=Sema-1a, isoform D {ECO:0000313|EMBL:ADV36981.1}; DE SubName: Full=Sema-1a, isoform E {ECO:0000313|EMBL:AAN10677.3}; GN Name=Sema-1a {ECO:0000313|EMBL:AAN10677.3, GN ECO:0000313|FlyBase:FBgn0011259}; GN ORFNames=CG18405 {ECO:0000313|FlyBase:FBgn0011259}, Dmel_CG18405 GN {ECO:0000313|EMBL:AAN10677.3}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Contains Sema domain. {ECO:0000256|SAAS:SAAS00037648}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAN10677.3; -; Genomic_DNA. DR EMBL; AE014134; ADV36981.1; -; Genomic_DNA. DR RefSeq; NP_001188731.1; NM_001201802.2. DR RefSeq; NP_609243.3; NM_135399.5. DR UniGene; Dm.13264; -. DR STRING; 7227.FBpp0302962; -. DR GeneID; 34192; -. DR KEGG; dme:Dmel_CG18405; -. DR UCSC; CG18405-RB; d. melanogaster. DR CTD; 34192; -. DR FlyBase; FBgn0011259; Sema-1a. DR eggNOG; KOG3611; Eukaryota. DR eggNOG; ENOG410XQZC; LUCA. DR KO; K06842; -. DR ChiTaRS; Sema-1a; fly. DR GenomeRNAi; 34192; -. DR NextBio; 787331; -. DR Proteomes; UP000000803; Chromosome 2L. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 2.130.10.10; -; 1. DR InterPro; IPR016201; Plexin-like_fold. DR InterPro; IPR002165; Plexin_repeat. DR InterPro; IPR001627; Semap_dom. DR InterPro; IPR027231; Semaphorin. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom. DR PANTHER; PTHR11036; PTHR11036; 1. DR Pfam; PF01437; PSI; 1. DR Pfam; PF01403; Sema; 1. DR SMART; SM00423; PSI; 1. DR SMART; SM00630; Sema; 1. DR SUPFAM; SSF101912; SSF101912; 1. DR SUPFAM; SSF103575; SSF103575; 1. DR PROSITE; PS51004; SEMA; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00037641}; KW Membrane {ECO:0000256|SAAS:SAAS00300463, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q0E8S4}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transmembrane {ECO:0000256|SAAS:SAAS00037688, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00037627, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 44 62 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 663 685 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 905 AA; 101611 MW; 288416CC89C86932 CRC64; MLNSHNTNHN NNSASNSNYN KGHKMHLKSA TAKATIMKHK LSKFYGYGWM QVFLLLTVLV IGNQSAWQEN IRPKLYVELG PEDVLKFVGN ESVVDHFKLV TKDGNSLLIG ARNTVFNLSI HDLVEQQRLV WTSPEDDTKM CLVKGKDEEA CQNYIRIMVV PSPGRLFVCG TNSFRPMCNT YIISDSNYTL EATKNGQAVC PYDPRHNSTS VLADNELYSG TVADFSGSDP IIYREPLQTE QYDSLSLNAP NFVSSFTQGD FVYFFFRETA VEFINCGKAI YSRVARVCKW DKGGPHRFRN RWTSFLKSRL NCSIPGDYPF YFNEIQSASN LVEGQYGSMS SKLIYGVFNT PSNSIPGSAV CAFALQDIAD TFEGQFKEQT GINSNWLPVN NAKVPDPRPG SCHNDSRALP DPTLNFIKTH SLMDENVPAF FSQPILVRTS TIYRFTQIAV DAQIKTPGGK TYDVIFVGTD HGKIIKSVNA ESADSADKVT SVVIEEIDVL TKSEPIRNLE IVRTMQYDQP KDGSYDDGKL IIVTDSQVVA IQLHRCHNDK ITSCSECVAL QDPYCAWDKI AGKCRSHGAP RWLEENYFYQ NVATGQHAAC PSGKINSKDA NAGEQKGFRN DMDLLDSRRQ SKDQEIIDNI DKNFEGPQIS ADIINAQYTV ETLVMAVLAG SIFSLLVGFF TGYFCGRRCH KDEDDNLPYP DTEYEYFEQR QNVNSFPSSC RIQQEPKLLP QVEEVTYAEP VLLPQPPPPN KMHSPKNTLR KPPMHQMHQG PNSETLFQFQ PDGYNTQQSY RGRDNFGTLR SHQVMGDNYR RGDGFSTTRS VKKAVNNTNT RNRSLGRARR QPPRHGIVTQ HRSNSPQQQQ QQSQQPHSSS GSSPVMSNSS SSPAPPSSSP SPQESPKNCS YIYRD //