ID Q0E8S4_DROME Unreviewed; 905 AA. AC Q0E8S4; DT 17-OCT-2006, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 27-MAR-2024, entry version 147. DE SubName: Full=Semaphorin 1a, isoform D {ECO:0000313|EMBL:ADV36981.1}; DE SubName: Full=Semaphorin 1a, isoform E {ECO:0000313|EMBL:AAN10677.3}; GN Name=Sema1a {ECO:0000313|EMBL:AAN10677.3, GN ECO:0000313|FlyBase:FBgn0011259}; GN Synonyms=BcDNA:RE36155 {ECO:0000313|EMBL:AAN10677.3}, CT26404 GN {ECO:0000313|EMBL:AAN10677.3}, D-Sema 1a GN {ECO:0000313|EMBL:AAN10677.3}, D-Sema I {ECO:0000313|EMBL:AAN10677.3}, GN d-sema I {ECO:0000313|EMBL:AAN10677.3}, D-Sema-I GN {ECO:0000313|EMBL:AAN10677.3}, D-SemaI {ECO:0000313|EMBL:AAN10677.3}, GN D-semaI {ECO:0000313|EMBL:AAN10677.3}, d-semaI GN {ECO:0000313|EMBL:AAN10677.3}, Dmel\CG18405 GN {ECO:0000313|EMBL:AAN10677.3}, Dsema 1a {ECO:0000313|EMBL:AAN10677.3}, GN Dsema-I {ECO:0000313|EMBL:AAN10677.3}, Fas-IV GN {ECO:0000313|EMBL:AAN10677.3}, FasIV {ECO:0000313|EMBL:AAN10677.3}, GN l(2)k13702 {ECO:0000313|EMBL:AAN10677.3}, sema GN {ECO:0000313|EMBL:AAN10677.3}, Sema 1a {ECO:0000313|EMBL:AAN10677.3}, GN sema 1a {ECO:0000313|EMBL:AAN10677.3}, SEMA-1A GN {ECO:0000313|EMBL:AAN10677.3}, Sema-1a {ECO:0000313|EMBL:AAN10677.3}, GN sema-1a {ECO:0000313|EMBL:AAN10677.3}, Sema-I GN {ECO:0000313|EMBL:AAN10677.3}, sema-I {ECO:0000313|EMBL:AAN10677.3}, GN Sema1A {ECO:0000313|EMBL:AAN10677.3}, sema1a GN {ECO:0000313|EMBL:AAN10677.3}, SemaI {ECO:0000313|EMBL:AAN10677.3}; GN ORFNames=CG18405 {ECO:0000313|EMBL:AAN10677.3, GN ECO:0000313|FlyBase:FBgn0011259}, Dmel_CG18405 GN {ECO:0000313|EMBL:AAN10677.3}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [9] {ECO:0000313|EMBL:AAN10677.3, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [10] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [11] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [12] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [13] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:AAN10677.3} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAN10677.3; -; Genomic_DNA. DR EMBL; AE014134; ADV36981.1; -; Genomic_DNA. DR RefSeq; NP_001188731.1; NM_001201802.2. DR RefSeq; NP_609243.3; NM_135399.5. DR AlphaFoldDB; Q0E8S4; -. DR SMR; Q0E8S4; -. DR IntAct; Q0E8S4; 106. DR EnsemblMetazoa; FBtr0303877; FBpp0292880; FBgn0011259. DR EnsemblMetazoa; FBtr0303878; FBpp0292881; FBgn0011259. DR GeneID; 34192; -. DR UCSC; CG18405-RB; d. melanogaster. DR AGR; FB:FBgn0011259; -. DR CTD; 34192; -. DR FlyBase; FBgn0011259; Sema1a. DR VEuPathDB; VectorBase:FBgn0011259; -. DR GeneTree; ENSGT00940000167882; -. DR OMA; KCRALVG; -. DR OrthoDB; 5399685at2759; -. DR BioGRID-ORCS; 34192; 0 hits in 3 CRISPR screens. DR ChiTaRS; Sema-1a; fly. DR GenomeRNAi; 34192; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0011259; Expressed in brain and 31 other cell types or tissues. DR ExpressionAtlas; Q0E8S4; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW. DR CDD; cd11237; Sema_1A; 1. DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1. DR InterPro; IPR002165; Plexin_repeat. DR InterPro; IPR016201; PSI. DR InterPro; IPR042068; SEM1A_sema_dom. DR InterPro; IPR001627; Semap_dom. DR InterPro; IPR036352; Semap_dom_sf. DR InterPro; IPR027231; Semaphorin. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR PANTHER; PTHR11036; SEMAPHORIN; 1. DR PANTHER; PTHR11036:SF127; SEMAPHORIN-1A; 1. DR Pfam; PF01437; PSI; 1. DR Pfam; PF01403; Sema; 1. DR SMART; SM00423; PSI; 1. DR SMART; SM00630; Sema; 1. DR SUPFAM; SSF103575; Plexin repeat; 1. DR SUPFAM; SSF101912; Sema domain; 1. DR PROSITE; PS51004; SEMA; 1. PE 1: Evidence at protein level; KW Differentiation {ECO:0000256|ARBA:ARBA00022782}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q0E8S4}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 44..62 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 663..685 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 74..543 FT /note="Sema" FT /evidence="ECO:0000259|PROSITE:PS51004" FT REGION 1..24 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 741..772 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 804..905 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 813..836 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 847..884 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 905 AA; 101611 MW; 288416CC89C86932 CRC64; MLNSHNTNHN NNSASNSNYN KGHKMHLKSA TAKATIMKHK LSKFYGYGWM QVFLLLTVLV IGNQSAWQEN IRPKLYVELG PEDVLKFVGN ESVVDHFKLV TKDGNSLLIG ARNTVFNLSI HDLVEQQRLV WTSPEDDTKM CLVKGKDEEA CQNYIRIMVV PSPGRLFVCG TNSFRPMCNT YIISDSNYTL EATKNGQAVC PYDPRHNSTS VLADNELYSG TVADFSGSDP IIYREPLQTE QYDSLSLNAP NFVSSFTQGD FVYFFFRETA VEFINCGKAI YSRVARVCKW DKGGPHRFRN RWTSFLKSRL NCSIPGDYPF YFNEIQSASN LVEGQYGSMS SKLIYGVFNT PSNSIPGSAV CAFALQDIAD TFEGQFKEQT GINSNWLPVN NAKVPDPRPG SCHNDSRALP DPTLNFIKTH SLMDENVPAF FSQPILVRTS TIYRFTQIAV DAQIKTPGGK TYDVIFVGTD HGKIIKSVNA ESADSADKVT SVVIEEIDVL TKSEPIRNLE IVRTMQYDQP KDGSYDDGKL IIVTDSQVVA IQLHRCHNDK ITSCSECVAL QDPYCAWDKI AGKCRSHGAP RWLEENYFYQ NVATGQHAAC PSGKINSKDA NAGEQKGFRN DMDLLDSRRQ SKDQEIIDNI DKNFEGPQIS ADIINAQYTV ETLVMAVLAG SIFSLLVGFF TGYFCGRRCH KDEDDNLPYP DTEYEYFEQR QNVNSFPSSC RIQQEPKLLP QVEEVTYAEP VLLPQPPPPN KMHSPKNTLR KPPMHQMHQG PNSETLFQFQ PDGYNTQQSY RGRDNFGTLR SHQVMGDNYR RGDGFSTTRS VKKAVNNTNT RNRSLGRARR QPPRHGIVTQ HRSNSPQQQQ QQSQQPHSSS GSSPVMSNSS SSPAPPSSSP SPQESPKNCS YIYRD //