ID Q09H18_MACMU Unreviewed; 182 AA. AC Q09H18; DT 17-OCT-2006, integrated into UniProtKB/TrEMBL. DT 17-OCT-2006, sequence version 1. DT 07-OCT-2020, entry version 85. DE RecName: Full=C-domain 1 {ECO:0000256|ARBA:ARBA00017930}; DE AltName: Full=C-domain 2 {ECO:0000256|ARBA:ARBA00017932}; DE AltName: Full=Cachectin {ECO:0000256|ARBA:ARBA00017220}; DE AltName: Full=Intracellular domain 1 {ECO:0000256|ARBA:ARBA00019113}; DE AltName: Full=Intracellular domain 2 {ECO:0000256|ARBA:ARBA00019116}; DE AltName: Full=N-terminal fragment {ECO:0000256|ARBA:ARBA00013652}; DE AltName: Full=TNF-alpha {ECO:0000256|ARBA:ARBA00018574}; DE AltName: Full=Tumor necrosis factor {ECO:0000256|ARBA:ARBA00013893}; DE AltName: Full=Tumor necrosis factor ligand superfamily member 2 {ECO:0000256|ARBA:ARBA00020063}; DE AltName: Full=Tumor necrosis factor, membrane form {ECO:0000256|ARBA:ARBA00020828}; DE AltName: Full=Tumor necrosis factor, soluble form {ECO:0000256|ARBA:ARBA00021382}; DE Flags: Fragment; GN Name=TNF-alpha {ECO:0000313|EMBL:ABI63795.1}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|EMBL:ABI63795.1}; RN [1] {ECO:0000313|EMBL:ABI63795.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=95027 {ECO:0000313|EMBL:ABI63789.1}, and 95114 RC {ECO:0000313|EMBL:ABI63795.1}; RX PubMed=17106666; DOI=10.1007/s00251-006-0166-6; RA Weiler A., May G.E., Qi Y., Wilson N., Watkins D.I.; RT "Polymorphisms in eight host genes associated with control of HIV RT replication do not mediate elite control of viral replication in SIV- RT infected Indian rhesus macaques."; RL Immunogenetics 58:1003-1009(2006). CC -!- FUNCTION: The TNF intracellular domain (ICD) form induces IL12 CC production in dendritic cells. {ECO:0000256|ARBA:ARBA00003559}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane CC protein {ECO:0000256|ARBA:ARBA00004606}. Secreted CC {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. CC {ECO:0000256|ARBA:ARBA00008670}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ902456; ABI63789.1; -; mRNA. DR EMBL; DQ902462; ABI63795.1; -; mRNA. DR HOGENOM; CLU_070352_3_1_1; -. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR CDD; cd00184; TNF; 1. DR Gene3D; 2.60.120.40; -; 1. DR InterPro; IPR006053; TNF. DR InterPro; IPR002959; TNF_alpha. DR InterPro; IPR021184; TNF_CS. DR InterPro; IPR006052; TNF_dom. DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom. DR PANTHER; PTHR11471:SF23; PTHR11471:SF23; 1. DR Pfam; PF00229; TNF; 1. DR PRINTS; PR01234; TNECROSISFCT. DR PRINTS; PR01235; TNFALPHA. DR SMART; SM00207; TNF; 1. DR SUPFAM; SSF49842; SSF49842; 1. DR PROSITE; PS00251; TNF_1; 1. DR PROSITE; PS50049; TNF_2; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cytokine {ECO:0000256|ARBA:ARBA00022514}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Myristate {ECO:0000256|ARBA:ARBA00022707}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}; KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..182 FT /note="C-domain 1" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5010133584" FT DOMAIN 54..182 FT /note="TNF_2" FT /evidence="ECO:0000259|PROSITE:PS50049" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ABI63795.1" FT NON_TER 182 FT /evidence="ECO:0000313|EMBL:ABI63795.1" SQ SEQUENCE 182 AA; 19957 MW; C0DDC5B18CA83FA8 CRC64; FSFLLVAGAT TLFCLLHFGV IGPQREEFPK DPSLISPLAQ AVRSSSRTPS DKPVAHVVAN PQAEGQLQWL NRRANALLAN GVELTDNQLV VPSEGLYLIY SQVLFKGQGC PSNHVLLTHT ISRIAVSYQT KVNLLSAIKS PCQRETPEGA EAKPWYEPIY LGGVFQLEKG DRLSAEINLP DY //