ID Q09H18_MACMU Unreviewed; 182 AA. AC Q09H18; DT 17-OCT-2006, integrated into UniProtKB/TrEMBL. DT 17-OCT-2006, sequence version 1. DT 09-JUL-2014, entry version 52. DE SubName: Full=Tumor necrosis factor alpha; DE Flags: Fragment; GN Name=TNF-alpha; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=95027, and 95114; RX PubMed=17106666; DOI=10.1007/s00251-006-0166-6; RA Weiler A., May G.E., Qi Y., Wilson N., Watkins D.I.; RT "Polymorphisms in eight host genes associated with control of HIV RT replication do not mediate elite control of viral replication in SIV- RT infected Indian rhesus macaques."; RL Immunogenetics 58:1003-1009(2006). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ902456; ABI63789.1; -; mRNA. DR EMBL; DQ902462; ABI63795.1; -; mRNA. DR UniGene; Mmu.3364; -. DR HOVERGEN; HBG012516; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl. DR GO; GO:0045121; C:membrane raft; IEA:Ensembl. DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0044212; F:transcription regulatory region DNA binding; IEA:Ensembl. DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl. DR GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl. DR GO; GO:0000185; P:activation of MAPKKK activity; IEA:Ensembl. DR GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:Ensembl. DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl. DR GO; GO:0071316; P:cellular response to nicotine; IEA:Ensembl. DR GO; GO:0002439; P:chronic inflammatory response to antigenic stimulus; IEA:Ensembl. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl. DR GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl. DR GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IEA:Ensembl. DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl. DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl. DR GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl. DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl. DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl. DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl. DR GO; GO:0050901; P:leukocyte tethering or rolling; IEA:Ensembl. DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl. DR GO; GO:0010693; P:negative regulation of alkaline phosphatase activity; IEA:Ensembl. DR GO; GO:0061048; P:negative regulation of branching involved in lung morphogenesis; IEA:Ensembl. DR GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Ensembl. DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl. DR GO; GO:0046325; P:negative regulation of glucose import; IEA:Ensembl. DR GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl. DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl. DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl. DR GO; GO:0043242; P:negative regulation of protein complex disassembly; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl. DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl. DR GO; GO:0009887; P:organ morphogenesis; IEA:Ensembl. DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl. DR GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; IEA:Ensembl. DR GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl. DR GO; GO:0002876; P:positive regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl. DR GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl. DR GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl. DR GO; GO:0031622; P:positive regulation of fever generation; IEA:Ensembl. DR GO; GO:0051798; P:positive regulation of hair follicle development; IEA:Ensembl. DR GO; GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IEA:Ensembl. DR GO; GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IEA:Ensembl. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl. DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl. DR GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl. DR GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl. DR GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IEA:Ensembl. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:0051533; P:positive regulation of NFAT protein import into nucleus; IEA:Ensembl. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl. DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl. DR GO; GO:0043243; P:positive regulation of protein complex disassembly; IEA:Ensembl. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl. DR GO; GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Ensembl. DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl. DR GO; GO:0045994; P:positive regulation of translational initiation by iron; IEA:Ensembl. DR GO; GO:0060557; P:positive regulation of vitamin D biosynthetic process; IEA:Ensembl. DR GO; GO:0000060; P:protein import into nucleus, translocation; IEA:Ensembl. DR GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl. DR GO; GO:0032800; P:receptor biosynthetic process; IEA:Ensembl. DR GO; GO:0060693; P:regulation of branching involved in salivary gland morphogenesis; IEA:Ensembl. DR GO; GO:0051023; P:regulation of immunoglobulin secretion; IEA:Ensembl. DR GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl. DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl. DR GO; GO:0009615; P:response to virus; IEA:Ensembl. DR GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl. DR GO; GO:0006927; P:transformed cell apoptotic process; IEA:Ensembl. DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl. DR Gene3D; 2.60.120.40; -; 1. DR InterPro; IPR006053; TNF. DR InterPro; IPR002959; TNF_alpha. DR InterPro; IPR021184; TNF_CS. DR InterPro; IPR006052; TNF_dom. DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom. DR Pfam; PF00229; TNF; 1. DR PRINTS; PR01234; TNECROSISFCT. DR PRINTS; PR01235; TNFALPHA. DR SMART; SM00207; TNF; 1. DR SUPFAM; SSF49842; SSF49842; 1. DR PROSITE; PS00251; TNF_1; 1. DR PROSITE; PS50049; TNF_2; 1. PE 2: Evidence at transcript level; KW Cytokine; Membrane. FT NON_TER 1 1 FT NON_TER 182 182 SQ SEQUENCE 182 AA; 19957 MW; C0DDC5B18CA83FA8 CRC64; FSFLLVAGAT TLFCLLHFGV IGPQREEFPK DPSLISPLAQ AVRSSSRTPS DKPVAHVVAN PQAEGQLQWL NRRANALLAN GVELTDNQLV VPSEGLYLIY SQVLFKGQGC PSNHVLLTHT ISRIAVSYQT KVNLLSAIKS PCQRETPEGA EAKPWYEPIY LGGVFQLEKG DRLSAEINLP DY //