ID Q09H18_MACMU Unreviewed; 182 AA. AC Q09H18; DT 17-OCT-2006, integrated into UniProtKB/TrEMBL. DT 17-OCT-2006, sequence version 1. DT 19-JAN-2010, entry version 27. DE SubName: Full=Tumor necrosis factor alpha; DE Flags: Fragment; GN Name=TNF-alpha; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=95114, and 95027; RX PubMed=17106666; DOI=10.1007/s00251-006-0166-6; RA Weiler A., May G.E., Qi Y., Wilson N., Watkins D.I.; RT "Polymorphisms in eight host genes associated with control of HIV RT replication do not mediate elite control of viral replication in SIV- RT infected Indian rhesus macaques."; RL Immunogenetics 58:1003-1009(2006). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ902456; ABI63789.1; -; mRNA. DR EMBL; DQ902462; ABI63795.1; -; mRNA. DR UniGene; Mmu.3364; -. DR SMR; Q09H18; 47-182. DR STRING; Q09H18; -. DR Ensembl; ENSMMUT00000012362; ENSMMUP00000011594; ENSMMUG00000008845; Macaca mulatta. DR HOVERGEN; Q09H18; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:Compara. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005887; C:integral to plasma membrane; IEA:Compara. DR GO; GO:0045121; C:membrane raft; IEA:Compara. DR GO; GO:0001891; C:phagocytic cup; IEA:Compara. DR GO; GO:0055037; C:recycling endosome; IEA:Compara. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0042802; F:identical protein binding; IEA:Compara. DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:Compara. DR GO; GO:0006919; P:activation of caspase activity; IEA:Compara. DR GO; GO:0000187; P:activation of MAPK activity; IEA:Compara. DR GO; GO:0006916; P:anti-apoptosis; IEA:Compara. DR GO; GO:0002439; P:chronic inflammatory response to antigenic ...; IEA:Compara. DR GO; GO:0042742; P:defense response to bacterium; IEA:Compara. DR GO; GO:0006006; P:glucose metabolic process; IEA:Compara. DR GO; GO:0006959; P:humoral immune response; IEA:Compara. DR GO; GO:0008625; P:induction of apoptosis via death domain rec...; IEA:Compara. DR GO; GO:0060555; P:induction of necroptosis by extracellular s...; IEA:Compara. DR GO; GO:0007254; P:JNK cascade; IEA:Compara. DR GO; GO:0050901; P:leukocyte tethering or rolling; IEA:Compara. DR GO; GO:0002740; P:negative regulation of cytokine secretion d...; IEA:Compara. DR GO; GO:0046325; P:negative regulation of glucose import; IEA:Compara. DR GO; GO:0032715; P:negative regulation of interleukin-6 produc...; IEA:Compara. DR GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Compara. DR GO; GO:0000122; P:negative regulation of transcription from R...; IEA:Compara. DR GO; GO:0045071; P:negative regulation of viral genome replica...; IEA:Compara. DR GO; GO:0009887; P:organ morphogenesis; IEA:Compara. DR GO; GO:0030316; P:osteoclast differentiation; IEA:Compara. DR GO; GO:0060559; P:positive regulation of calcidiol 1-monooxyg...; IEA:Compara. DR GO; GO:0045080; P:positive regulation of chemokine biosynthet...; IEA:Compara. DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Compara. DR GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Compara. DR GO; GO:0043193; P:positive regulation of gene-specific transc...; IEA:Compara. DR GO; GO:0051798; P:positive regulation of hair follicle develo...; IEA:Compara. DR GO; GO:0034116; P:positive regulation of heterotypic cell-cel...; IEA:Compara. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-k...; IEA:Compara. DR GO; GO:0032755; P:positive regulation of interleukin-6 produc...; IEA:Compara. DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Compara. DR GO; GO:0051044; P:positive regulation of membrane protein ect...; IEA:Compara. DR GO; GO:0042346; P:positive regulation of NF-kappaB import int...; IEA:Compara. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcript...; IEA:Compara. DR GO; GO:0045429; P:positive regulation of nitric oxide biosynt...; IEA:Compara. DR GO; GO:0001934; P:positive regulation of protein amino acid p...; IEA:Compara. DR GO; GO:0048661; P:positive regulation of smooth muscle cell p...; IEA:Compara. DR GO; GO:0045944; P:positive regulation of transcription from R...; IEA:Compara. DR GO; GO:0045994; P:positive regulation of translational initia...; IEA:Compara. DR GO; GO:0060557; P:positive regulation of vitamin D biosynthet...; IEA:Compara. DR GO; GO:0000060; P:protein import into nucleus, translocation; IEA:Compara. DR GO; GO:0032800; P:receptor biosynthetic process; IEA:Compara. DR GO; GO:0051023; P:regulation of immunoglobulin secretion; IEA:Compara. DR GO; GO:0050796; P:regulation of insulin secretion; IEA:Compara. DR GO; GO:0045670; P:regulation of osteoclast differentiation; IEA:Compara. DR GO; GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara. DR GO; GO:0009615; P:response to virus; IEA:Compara. DR GO; GO:0030730; P:sequestering of triglyceride; IEA:Compara. DR GO; GO:0006927; P:transformed cell apoptosis; IEA:Compara. DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pa...; IEA:Compara. DR InterPro; IPR006053; TNF_a/b/c. DR InterPro; IPR002959; TNF_alpha. DR InterPro; IPR006052; TNF_family. DR InterPro; IPR008983; Tumour_necrosis_fac-like. DR Gene3D; G3DSA:2.60.120.40; Tumour_necrosis_fac-like; 1. DR Pfam; PF00229; TNF; 1. DR PRINTS; PR01234; TNECROSISFCT. DR PRINTS; PR01235; TNFALPHA. DR SMART; SM00207; TNF; 1. DR PROSITE; PS00251; TNF_1; 1. DR PROSITE; PS50049; TNF_2; 1. PE 2: Evidence at transcript level; KW Cytokine; Membrane. FT NON_TER 1 1 FT NON_TER 182 182 SQ SEQUENCE 182 AA; 19957 MW; C0DDC5B18CA83FA8 CRC64; FSFLLVAGAT TLFCLLHFGV IGPQREEFPK DPSLISPLAQ AVRSSSRTPS DKPVAHVVAN PQAEGQLQWL NRRANALLAN GVELTDNQLV VPSEGLYLIY SQVLFKGQGC PSNHVLLTHT ISRIAVSYQT KVNLLSAIKS PCQRETPEGA EAKPWYEPIY LGGVFQLEKG DRLSAEINLP DY //