ID LAG3_CAEEL Reviewed; 490 AA. AC Q09260; Q9NGS2; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 06-JUN-2002, sequence version 2. DT 23-OCT-2007, entry version 46. DE Protein lag-3 (Abnormal germline proliferation protein 3) (Abnormal DE cell lineage protein 3). GN Name=sel-8; Synonyms=lag-3; ORFNames=C32A3.1; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). RX MEDLINE=20289813; PubMed=10830967; DOI=10.1038/35012645; RA Petcherski A.G., Kimble J.; RT "LAG-3 is a putative transcriptional activator in the C. elegans Notch RT pathway."; RL Nature 405:364-368(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). RN [3] RP SEQUENCE REVISION, AND ALTERNATIVE SPLICING. RG WormBase consortium; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Glp-1 and lin-12 promote signalling by recruiting lag-3 CC to target promoters, where it functions as a transcriptional CC activator. CC -!- SUBUNIT: Associates with lag-1. CC -!- INTERACTION: CC O17670:eya-1; NbExp=1; IntAct=EBI-317579, EBI-311862; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=a; CC IsoId=Q09260-1; Sequence=Displayed; CC Name=b; CC IsoId=Q09260-2; Sequence=VSP_003908; CC Note=No experimental confirmation available; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF241847; AAF71523.1; -; mRNA. DR EMBL; AF241846; AAF71522.1; -; mRNA. DR EMBL; Z48241; CAA88284.1; -; Genomic_DNA. DR EMBL; Z48241; CAC42265.1; -; Genomic_DNA. DR PIR; T19628; T19628. DR RefSeq; NP_001021194.1; -. DR UniGene; Cel.19503; -. DR PDB; 2FO1; X-ray; D=-. DR SMR; Q09260; 52-114. DR IntAct; Q09260; -. DR Ensembl; C32A3.1; Caenorhabditis elegans. DR GeneID; 175464; -. DR WormBase; WBGene00004765; sel-8. DR WormPep; C32A3.1a; CE27810. DR WormPep; C32A3.1b; CE01505. DR GO; GO:0005515; F:protein binding; IPI:IntAct. PE 1: Evidence at protein level; KW 3D-structure; Activator; Alternative splicing; Complete proteome; KW Nucleus; Transcription; Transcription regulation. FT CHAIN 1 490 Protein lag-3. FT /FTId=PRO_0000084353. FT COMPBIAS 162 467 Gln-rich. FT COMPBIAS 185 188 Poly-Gln. FT COMPBIAS 341 346 Poly-Gln. FT COMPBIAS 353 357 Poly-Gln. FT COMPBIAS 372 380 Poly-Gln. FT COMPBIAS 390 400 Poly-Gln. FT COMPBIAS 433 442 Poly-Gln. FT VAR_SEQ 1 22 Missing (in isoform b). FT /FTId=VSP_003908. SQ SEQUENCE 490 AA; 56482 MW; 396A6C194C382A07 CRC64; MDDLSEFFVI EEMFISEPSV AGMKPSTSKT THSPPPEEPT APFVNDNLPN PEDEPTIGDL NAFHSGEELH RQRSELARAN YEKARPEMIA NQRAVTAHLF NRYTEDEERK RVEQQKNKEA MNASTSAPTS SRNGGQSVEN RKRRNDVVVA PPTSEEEWKR AQQQHWMGQQ QPQMQFQMQQ QYHSQQQQYI MMQQQHHHMT GMQQIHHQMP STSSADSIRS VPTPASSMHQ PSPAEMRNGC GMSRNATMDM TCSPMSGGQP IVDENNLAVP EGEWFDKLAL AVAEQYNVDT ILGPDTYDTF LAELDFSSSE SPTKQSPMEM NGDRMPSTAP PPAQNPQHIA QLQQQQNKMR LMQQQQQEMQ RIEQQRRQQI MQQQQQQQQQ EHQRQQMLLQ QQQQQQQMQQ HHQMNGGGQF ATQAHQQAAY MQQMQRMEQI RHQQQQAQQH QQAQQQHQQQ AQHHQMGYGI PNGYPQQMHM HPPAYGAHHM PQPTAFANIN //