ID   Q08C83_DANRE            Unreviewed;       298 AA.
AC   Q08C83;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   28-JUN-2023, entry version 99.
DE   SubName: Full=Mitochondrial 2-oxodicarboxylate carrier {ECO:0000313|RefSeq:NP_001070100.1};
DE   SubName: Full=Solute carrier family 25 (Mitochondrial oxodicarboxylate carrier), member 21 {ECO:0000313|EMBL:AAI24343.1};
GN   Name=zgc:153387 {ECO:0000313|RefSeq:NP_001070100.1};
GN   OrderedLocusNames=slc25a21 {ECO:0000313|EMBL:AAI24343.1,
GN   ECO:0000313|RefSeq:NP_001070100.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-060929-664};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI24343.1};
RN   [1] {ECO:0000313|EMBL:AAI24343.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary {ECO:0000313|EMBL:AAI24343.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|RefSeq:NP_001070100.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18335061;
RA   Sreenivasan R., Cai M., Bartfai R., Wang X., Christoffels A., Orban L.;
RT   "Transcriptomic analyses reveal novel genes with sexually dimorphic
RT   expression in the zebrafish gonad and brain.";
RL   PLoS ONE 3:E1791-E1791(2008).
RN   [3] {ECO:0000313|RefSeq:NP_001070100.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [4] {ECO:0000313|RefSeq:NP_001070100.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27086301;
RA   Garcia-Reyero N., Escalon L., Prats E., Faria M., Soares A.M., Raldua D.;
RT   "Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon
RT   Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes.";
RL   Bull. Environ. Contam. Toxicol. 96:707-713(2016).
RN   [5] {ECO:0000313|RefSeq:NP_001070100.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30621336;
RA   Calvello R., Cianciulli A., Mitolo V., Porro A., Panaro M.A.;
RT   "Conservation of Intronic Sequences in Vertebrate Mitochondrial Solute
RT   Carrier Genes (Zebrafish, Chicken, Mouse and Human).";
RL   Noncoding RNA 5:E4-E4(2019).
RN   [6] {ECO:0000313|RefSeq:NP_001070100.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR   EMBL; BC124342; AAI24343.1; -; mRNA.
DR   RefSeq; NP_001070100.1; NM_001076632.1.
DR   GeneID; 767694; -.
DR   KEGG; dre:767694; -.
DR   CTD; 89874; -.
DR   ZFIN; ZDB-GENE-060929-664; slc25a21.
DR   OrthoDB; 314985at2759; -.
DR   PhylomeDB; Q08C83; -.
DR   Proteomes; UP000000437; Chromosome 17.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   PANTHER; PTHR46356; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER; 1.
DR   PANTHER; PTHR46356:SF1; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00282};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q08C83};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00282};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT   REPEAT          10..99
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          106..195
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          204..293
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ   SEQUENCE   298 AA;  32998 MW;  13E92589737ACDFA CRC64;
     MTSKKKSLLR EASHQIIAGG SAGLVEICLM HPLDVVKTRF QIQRGKSDPN SYKGLGDCFR
     TIFRTEGVYG FYKGILPPIL AETPKRAVKF FTFEQYKKLL SFTSLSPGMA LSVAGLGSGL
     TEALVVNPFE VVKVSLQANR DSFKVQPSTF AQARNIINTD GFGLRGLNKG LTSTLGRHGV
     FNMIYFGFYF NVKDAIPASQ DPRLEFMRKF AIGLVSGTVS SCVNIPFDVA KSRIQGPQPV
     PGEIKYRSCF QSMALVYREE GYLALYKGLI PKIMRLGPGG AVMLLVYEYM SGWLQKNW
//