ID Q08C83_DANRE Unreviewed; 298 AA. AC Q08C83; DT 31-OCT-2006, integrated into UniProtKB/TrEMBL. DT 31-OCT-2006, sequence version 1. DT 03-AUG-2022, entry version 95. DE SubName: Full=Solute carrier family 25 (Mitochondrial oxodicarboxylate carrier), member 21 {ECO:0000313|EMBL:AAI24343.1}; DE SubName: Full=mitochondrial 2-oxodicarboxylate carrier {ECO:0000313|RefSeq:NP_001070100.1}; GN Name=zgc:153387 {ECO:0000313|RefSeq:NP_001070100.1}; GN OrderedLocusNames=slc25a21 {ECO:0000313|EMBL:AAI24343.1, GN ECO:0000313|RefSeq:NP_001070100.1, GN ECO:0000313|ZFIN:ZDB-GENE-060929-664}; GN ORFNames=SO:0001217 {ECO:0000313|ZFIN:ZDB-GENE-060929-664}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI24343.1}; RN [1] {ECO:0000313|EMBL:AAI24343.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Ovary {ECO:0000313|EMBL:AAI24343.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|RefSeq:NP_001070100.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18335061; RA Sreenivasan R., Cai M., Bartfai R., Wang X., Christoffels A., Orban L.; RT "Transcriptomic analyses reveal novel genes with sexually dimorphic RT expression in the zebrafish gonad and brain."; RL PLoS ONE 3:e1791-e1791(2008). RN [3] {ECO:0000313|RefSeq:NP_001070100.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [4] {ECO:0000313|RefSeq:NP_001070100.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27086301; RA Garcia-Reyero N., Escalon L., Prats E., Faria M., Soares A.M., Raldua D.; RT "Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon RT Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes."; RL Bull. Environ. Contam. Toxicol. 96:707-713(2016). RN [5] {ECO:0000313|RefSeq:NP_001070100.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30621336; RA Calvello R., Cianciulli A., Mitolo V., Porro A., Panaro M.A.; RT "Conservation of Intronic Sequences in Vertebrate Mitochondrial Solute RT Carrier Genes (Zebrafish, Chicken, Mouse and Human)."; RL Noncoding RNA 5:E4-E4(2019). RN [6] {ECO:0000313|RefSeq:NP_001070100.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family. CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC124342; AAI24343.1; -; mRNA. DR RefSeq; NP_001070100.1; NM_001076632.1. DR GeneID; 767694; -. DR KEGG; dre:767694; -. DR CTD; 89874; -. DR ZFIN; ZDB-GENE-060929-664; slc25a21. DR ZFIN; ZDB-GENE-060929-664; SO:0001217. DR OrthoDB; 1236425at2759; -. DR PhylomeDB; Q08C83; -. DR Proteomes; UP000000437; Chromosome 17. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro. DR Gene3D; 1.50.40.10; -; 2. DR InterPro; IPR002067; Mit_carrier. DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier. DR InterPro; IPR023395; Mt_carrier_dom_sf. DR Pfam; PF00153; Mito_carr; 3. DR PRINTS; PR00926; MITOCARRIER. DR SUPFAM; SSF103506; SSF103506; 1. DR PROSITE; PS50920; SOLCAR; 3. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE- KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE- KW ProRule:PRU00282}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}. FT REPEAT 10..99 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" FT REPEAT 106..195 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" FT REPEAT 204..293 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" SQ SEQUENCE 298 AA; 32998 MW; 13E92589737ACDFA CRC64; MTSKKKSLLR EASHQIIAGG SAGLVEICLM HPLDVVKTRF QIQRGKSDPN SYKGLGDCFR TIFRTEGVYG FYKGILPPIL AETPKRAVKF FTFEQYKKLL SFTSLSPGMA LSVAGLGSGL TEALVVNPFE VVKVSLQANR DSFKVQPSTF AQARNIINTD GFGLRGLNKG LTSTLGRHGV FNMIYFGFYF NVKDAIPASQ DPRLEFMRKF AIGLVSGTVS SCVNIPFDVA KSRIQGPQPV PGEIKYRSCF QSMALVYREE GYLALYKGLI PKIMRLGPGG AVMLLVYEYM SGWLQKNW //