ID Q08C83_DANRE Unreviewed; 298 AA. AC Q08C83; DT 31-OCT-2006, integrated into UniProtKB/TrEMBL. DT 31-OCT-2006, sequence version 1. DT 24-JUL-2024, entry version 105. DE RecName: Full=Mitochondrial 2-oxodicarboxylate carrier {ECO:0000256|ARBA:ARBA00039747}; DE AltName: Full=Solute carrier family 25 member 21 {ECO:0000256|ARBA:ARBA00041874}; GN Name=slc25a21 {ECO:0000313|EMBL:AAI24343.1, GN ECO:0000313|RefSeq:NP_001070100.1, GN ECO:0000313|ZFIN:ZDB-GENE-060929-664}; GN Synonyms=zgc:153387 {ECO:0000313|RefSeq:NP_001070100.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI24343.1}; RN [1] {ECO:0000313|EMBL:AAI24343.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Ovary {ECO:0000313|EMBL:AAI24343.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|RefSeq:NP_001070100.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18335061; RA Sreenivasan R., Cai M., Bartfai R., Wang X., Christoffels A., Orban L.; RT "Transcriptomic analyses reveal novel genes with sexually dimorphic RT expression in the zebrafish gonad and brain."; RL PLoS ONE 3:E1791-E1791(2008). RN [3] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [4] {ECO:0000313|RefSeq:NP_001070100.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [5] {ECO:0000313|RefSeq:NP_001070100.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27086301; DOI=10.1007/s00128-016-1798-3; RA Garcia-Reyero N., Escalon L., Prats E., Faria M., Soares A.M., Raldua D.; RT "Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon RT Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes."; RL Bull. Environ. Contam. Toxicol. 96:707-713(2016). RN [6] {ECO:0000313|RefSeq:NP_001070100.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30621336; RA Calvello R., Cianciulli A., Mitolo V., Porro A., Panaro M.A.; RT "Conservation of Intronic Sequences in Vertebrate Mitochondrial Solute RT Carrier Genes (Zebrafish, Chicken, Mouse and Human)."; RL Noncoding RNA 5:E4-E4(2019). RN [7] {ECO:0000313|RefSeq:NP_001070100.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (APR-2024) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + CC 2-oxoglutarate(in); Xref=Rhea:RHEA:71739, ChEBI:CHEBI:16810, CC ChEBI:CHEBI:57499; Evidence={ECO:0000256|ARBA:ARBA00036018}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoglutarate(out) + 2-oxoheptanedioate(in) = 2- CC oxoglutarate(in) + 2-oxoheptanedioate(out); Xref=Rhea:RHEA:71755, CC ChEBI:CHEBI:16810, ChEBI:CHEBI:72701; CC Evidence={ECO:0000256|ARBA:ARBA00036835}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoglutarate(out) + L-2-aminoadipate(in) = 2- CC oxoglutarate(in) + L-2-aminoadipate(out); Xref=Rhea:RHEA:71747, CC ChEBI:CHEBI:16810, ChEBI:CHEBI:58672; CC Evidence={ECO:0000256|ARBA:ARBA00036155}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoglutarate(out) + citrate(in) = 2-oxoglutarate(in) + CC citrate(out); Xref=Rhea:RHEA:71763, ChEBI:CHEBI:16810, CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00036610}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) + CC glutarate(out); Xref=Rhea:RHEA:71751, ChEBI:CHEBI:16810, CC ChEBI:CHEBI:30921; Evidence={ECO:0000256|ARBA:ARBA00036317}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoglutarate(out) + heptanedioate(in) = 2-oxoglutarate(in) + CC heptanedioate(out); Xref=Rhea:RHEA:71759, ChEBI:CHEBI:16810, CC ChEBI:CHEBI:36165; Evidence={ECO:0000256|ARBA:ARBA00036103}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoglutarate(out) + hexanedioate(in) = 2-oxoglutarate(in) + CC hexanedioate(out); Xref=Rhea:RHEA:71743, ChEBI:CHEBI:16810, CC ChEBI:CHEBI:17128; Evidence={ECO:0000256|ARBA:ARBA00036872}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family. CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC124342; AAI24343.1; -; mRNA. DR RefSeq; NP_001070100.1; NM_001076632.1. DR GeneID; 767694; -. DR KEGG; dre:767694; -. DR AGR; ZFIN:ZDB-GENE-060929-664; -. DR CTD; 89874; -. DR ZFIN; ZDB-GENE-060929-664; slc25a21. DR OrthoDB; 314985at2759; -. DR PhylomeDB; Q08C83; -. DR Reactome; R-DRE-71064; Lysine catabolism. DR Proteomes; UP000000437; Chromosome 17. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro. DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2. DR InterPro; IPR002067; Mit_carrier. DR InterPro; IPR051752; Mito_2-oxodicarb_carrier. DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier. DR InterPro; IPR023395; Mt_carrier_dom_sf. DR PANTHER; PTHR46356; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER; 1. DR PANTHER; PTHR46356:SF1; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER; 1. DR Pfam; PF00153; Mito_carr; 3. DR PRINTS; PR00926; MITOCARRIER. DR SUPFAM; SSF103506; Mitochondrial carrier; 1. DR PROSITE; PS50920; SOLCAR; 3. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE- KW ProRule:PRU00282}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q08C83}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE- KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}. FT REPEAT 10..99 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" FT REPEAT 106..195 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" FT REPEAT 204..293 FT /note="Solcar" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282" SQ SEQUENCE 298 AA; 32998 MW; 13E92589737ACDFA CRC64; MTSKKKSLLR EASHQIIAGG SAGLVEICLM HPLDVVKTRF QIQRGKSDPN SYKGLGDCFR TIFRTEGVYG FYKGILPPIL AETPKRAVKF FTFEQYKKLL SFTSLSPGMA LSVAGLGSGL TEALVVNPFE VVKVSLQANR DSFKVQPSTF AQARNIINTD GFGLRGLNKG LTSTLGRHGV FNMIYFGFYF NVKDAIPASQ DPRLEFMRKF AIGLVSGTVS SCVNIPFDVA KSRIQGPQPV PGEIKYRSCF QSMALVYREE GYLALYKGLI PKIMRLGPGG AVMLLVYEYM SGWLQKNW //