ID GAB3_DROME STANDARD; PRT; 496 AA. AC Q08832; DT 01-FEB-1995 (Rel. 31, Created) DT 01-FEB-1995 (Rel. 31, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA-LIKE SUBUNIT PRECURSOR (GABA(A) DE RECEPTOR). GN LCCH3. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=CANTON-S; RX MEDLINE; 93290631. RA HENDERSON J.E., SODERLUND D.M., KNIPPLE D.C.; RT "Characterization of a putative gamma-aminobutyric acid (GABA) RT receptor beta subunit gene from Drosophila melanogaster."; RL Biochem. Biophys. Res. Commun. 193:474-482(1993). CC -!- FUNCTION: GABA, AN INHIBITORY NEUROTRANSMITTER, MEDIATES NEURONAL CC INHIBITION BY BINDING TO THE GABA RECEPTOR AND OPENING AN INTEGRAL CC CHLORIDE CHANNEL (BY SIMILARITY). CC -!- SUBUNIT: GENERALLY PENTAMERIC. THERE ARE FIVE TYPES OF GABA(A) CC RECEPTOR CHAINS: ALPHA, BETA, GAMMA, DELTA, AND RHO. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- SIMILARITY: BELONGS TO THE LIGAND-GATED IONIC CHANNELS FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L17436; AAA28559.1; -. DR EMBL; S62717; AAB27090.1; -. DR PIR; JN0603; JN0603. DR FLYBASE; FBgn0010240; Lcch3. DR PFAM; PF00065; neur_chan; 2. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. KW Postsynaptic membrane; Ionic channel; Glycoprotein; Signal; KW Transmembrane. FT SIGNAL 1 20 OR 27 (POTENTIAL). FT CHAIN 21 496 GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA- FT LIKE SUBUNIT. FT DOMAIN 21 258 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 259 280 POTENTIAL. FT TRANSMEM 285 306 POTENTIAL. FT TRANSMEM 318 342 POTENTIAL. FT DOMAIN 343 472 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 473 494 POTENTIAL. FT CARBOHYD 39 39 POTENTIAL. FT CARBOHYD 189 189 POTENTIAL. FT DISULFID 176 190 BY SIMILARITY. SQ SEQUENCE 496 AA; 56627 MW; 5254829D CRC32; MTCFTRVGVS CSLFFFLLGA QLQLIRCIRK DVLAGRLENV TQTISNILQG YDIRLRPNFG GEPLHVGMDL TIASFDAISE VNMDYTITMY LNQYWRDERL AFNIFGQYFD DENDDGISDV LTLSGDFAEK IWVPDTFFAN DKNSFLHDVT ERNKLVRLGG DGAVTYGMRF TTTLACMMDL HYYPLDSQNC TVEIESYGYT VSDVVMYWKP TPVRGVEDAE LPQFTIIGYE TNDRKERLAT GVYQRLSLSF KLQRNIGYFV FQTYLPSILI VMLSWVSFWI NHEATSARVA LGITTVLTMT TISTGVRSSL PRISYVKAID IYLVMCFVFV FAALLEYAAV NYTYWGKRAK KKIKKVKECC PGKIGKSERS ETCSTTEDII ELQDVRMSPI PSLRRGTYNA TLDSIGTETM NLGKFPPSFR ITRNYGTGHS QLRRRAQRGI STRPRMLHAL KRGASAIKAT IPKIKDVNII DKYSRMIFPI SFLAFNLGYW LFYILE //