ID GAB3_DROME STANDARD; PRT; 496 AA. AC Q08832; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA-LIKE SUBUNIT (GABA(A) RECEPTOR). GN LCCH3. OS DROSOPHILA MELANOGASTER (FRUIT FLY). OC EUKARYOTA; METAZOA; ARTHROPODA; INSECTA; DIPTERA. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=CANTON-S; RX MEDLINE; 93290631. RA HENDERSON J.E., SODERLUND D.M., KNIPPLE D.C.; RL BIOCHEM. BIOPHYS. RES. COMMUN. 193:474-482(1993). CC -!- FUNCTION: GABA, AN INHIBITORY NEUROTRANSMITTER, MEDIATES NEURONAL CC INHIBITION BY BINDING TO THE GABA RECEPTOR AND OPENING AN INTEGRAL CC CHLORIDE CHANNEL (BY SIMILARITY). CC -!- SUBUNIT: GENERALLY PENTAMERIC. THERE ARE FIVE TYPES OF GABA(A) CC RECEPTOR CHAINS: ALPHA, BETA, GAMMA, DELTA, AND RHO. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- SIMILARITY: BELONGS TO THE LIGAND-GATED IONIC CHANNELS FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L17436; L17436. DR EMBL; S62717; S62717. DR PIR; JN0603; JN0603. DR FLYBASE; FBGN0010240; LCCH3. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL. KW POSTSYNAPTIC MEMBRANE; IONIC CHANNEL; GLYCOPROTEIN; SIGNAL; KW TRANSMEMBRANE. FT SIGNAL 1 20 OR 27 (POTENTIAL). FT CHAIN 21 496 GAMMA-AMINOBUTYRIC-ACID RECEPTOR BETA- FT LIKE SUBUNIT. FT DOMAIN 21 258 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 259 280 POTENTIAL. FT TRANSMEM 285 306 POTENTIAL. FT TRANSMEM 318 342 POTENTIAL. FT DOMAIN 343 472 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 473 494 POTENTIAL. FT CARBOHYD 39 39 POTENTIAL. FT CARBOHYD 189 189 POTENTIAL. FT DISULFID 176 190 BY SIMILARITY. SQ SEQUENCE 496 AA; 56627 MW; 1329660 CN; MTCFTRVGVS CSLFFFLLGA QLQLIRCIRK DVLAGRLENV TQTISNILQG YDIRLRPNFG GEPLHVGMDL TIASFDAISE VNMDYTITMY LNQYWRDERL AFNIFGQYFD DENDDGISDV LTLSGDFAEK IWVPDTFFAN DKNSFLHDVT ERNKLVRLGG DGAVTYGMRF TTTLACMMDL HYYPLDSQNC TVEIESYGYT VSDVVMYWKP TPVRGVEDAE LPQFTIIGYE TNDRKERLAT GVYQRLSLSF KLQRNIGYFV FQTYLPSILI VMLSWVSFWI NHEATSARVA LGITTVLTMT TISTGVRSSL PRISYVKAID IYLVMCFVFV FAALLEYAAV NYTYWGKRAK KKIKKVKECC PGKIGKSERS ETCSTTEDII ELQDVRMSPI PSLRRGTYNA TLDSIGTETM NLGKFPPSFR ITRNYGTGHS QLRRRAQRGI STRPRMLHAL KRGASAIKAT IPKIKDVNII DKYSRMIFPI SFLAFNLGYW LFYILE //