ID ADCY2_HUMAN Reviewed; 1091 AA. AC Q08462; Q2NKL8; Q9UPU2; DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot. DT 28-NOV-2006, sequence version 5. DT 03-NOV-2009, entry version 96. DE RecName: Full=Adenylate cyclase type 2; DE EC=4.6.1.1; DE AltName: Full=Adenylate cyclase type II; DE AltName: Full=ATP pyrophosphate-lyase 2; DE AltName: Full=Adenylyl cyclase 2; GN Name=ADCY2; Synonyms=KIAA1060; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Guo J.H., Yu L.; RT "Molecular cloning of human adenylyl cyclase gene."; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-147. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-1091. RC TISSUE=Brain; RX MEDLINE=99397452; PubMed=10470851; DOI=10.1093/dnares/6.3.197; RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., RA Tanaka A., Kotani H., Nomura N., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XIV. RT The complete sequences of 100 new cDNA clones from brain which code RT for large proteins in vitro."; RL DNA Res. 6:197-205(1999). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 616-1091. RC TISSUE=Brain; RX MEDLINE=93052215; PubMed=1427768; DOI=10.1007/BF00210755; RA Stengel D., Parma J., Gannage M.-H., Roeckel N., Mattei M.-G., RA Barouki R., Hanoune J.; RT "Different chromosomal localization of two adenylyl cyclase genes RT expressed in human brain."; RL Hum. Genet. 90:126-130(1992). CC -!- FUNCTION: This is a membrane-bound, calmodulin-insensitive CC adenylyl cyclase. CC -!- CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate. CC -!- COFACTOR: Binds 2 magnesium ions per subunit (By similarity). CC -!- ENZYME REGULATION: Insensitive to calcium/calmodulin. Stimulated CC by the G protein beta and gamma subunit complex (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in brain. CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl CC cyclase family. CC -!- SIMILARITY: Contains 2 guanylate cyclase domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF410885; AAP97285.1; -; mRNA. DR EMBL; BC111743; AAI11744.1; -; mRNA. DR EMBL; AB028983; BAA83012.1; -; mRNA. DR EMBL; X74210; CAA52282.1; -; mRNA. DR EMBL; L21993; AAA64923.1; -; mRNA. DR IPI; IPI00328273; -. DR PIR; I37136; I37136. DR RefSeq; NP_065433.2; -. DR UniGene; Hs.481545; -. DR HSSP; P26769; 1AB8. DR SMR; Q08462; 879-1078. DR DIP; DIP:422N; -. DR STRING; Q08462; -. DR PhosphoSite; Q08462; -. DR PRIDE; Q08462; -. DR Ensembl; ENST00000338316; ENSP00000342952; ENSG00000078295; Homo sapiens. DR Ensembl; ENST00000382531; ENSP00000371971; ENSG00000078295; Homo sapiens. DR Ensembl; ENST00000382532; ENSP00000371972; ENSG00000078295; Homo sapiens. DR GeneID; 108; -. DR KEGG; hsa:108; -. DR UCSC; uc003jdz.1; human. DR CTD; 108; -. DR GeneCards; GC05P007449; -. DR GeneCards; GC05P007450; -. DR HGNC; HGNC:233; ADCY2. DR MIM; 103071; gene. DR PharmGKB; PA24561; -. DR HOVERGEN; Q08462; -. DR OMA; FLPYFIY; -. DR BRENDA; 4.6.1.1; 247. DR Pathway_Interaction_DB; endothelinpathway; Endothelins. DR Pathway_Interaction_DB; lysophospholipid_pathway; LPA receptor mediated events. DR Pathway_Interaction_DB; lpa4_pathway; LPA4-mediated signaling events. DR Reactome; REACT_11061; Signalling by NGF. DR Reactome; REACT_14797; Signaling by GPCR. DR Reactome; REACT_1505; Integration of energy metabolism. DR Reactome; REACT_15295; Opioid Signalling. DR NextBio; 419; -. DR ArrayExpress; Q08462; -. DR Bgee; Q08462; -. DR CleanEx; HS_ADCY2; -. DR Genevestigator; Q08462; -. DR GermOnline; ENSG00000078295; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; NAS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; EXP:Reactome. DR GO; GO:0004016; F:adenylate cyclase activity; NAS:UniProtKB. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW. DR GO; GO:0007189; P:activation of adenylate cyclase activity by...; EXP:Reactome. DR GO; GO:0034199; P:activation of protein kinase A activity; EXP:Reactome. DR GO; GO:0006171; P:cAMP biosynthetic process; NAS:UniProtKB. DR GO; GO:0009755; P:hormone-mediated signaling; EXP:Reactome. DR GO; GO:0007193; P:inhibition of adenylate cyclase activity by...; EXP:Reactome. DR InterPro; IPR001054; A/G_cyclase. DR InterPro; IPR018297; A/G_cyclase_CS. DR InterPro; IPR009398; Aden_cycl-like. DR Gene3D; G3DSA:3.30.70.1230; A/G_cyclase; 2. DR Pfam; PF06327; DUF1053; 1. DR Pfam; PF00211; Guanylate_cyc; 2. DR SMART; SM00044; CYCc; 2. DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 2. DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2. PE 2: Evidence at transcript level; KW ATP-binding; cAMP biosynthesis; Complete proteome; Glycoprotein; KW Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; KW Polymorphism; Repeat; Transmembrane. FT CHAIN 1 1091 Adenylate cyclase type 2. FT /FTId=PRO_0000195684. FT TOPO_DOM 1 45 Cytoplasmic (Potential). FT TRANSMEM 46 66 Potential. FT TRANSMEM 76 96 Potential. FT TRANSMEM 108 128 Potential. FT TRANSMEM 133 153 Potential. FT TRANSMEM 159 179 Potential. FT TRANSMEM 187 207 Potential. FT TOPO_DOM 208 601 Cytoplasmic (Potential). FT TRANSMEM 602 622 Potential. FT TRANSMEM 628 652 Potential. FT TRANSMEM 680 701 Potential. FT TRANSMEM 734 755 Potential. FT TRANSMEM 763 780 Potential. FT TRANSMEM 801 821 Potential. FT TOPO_DOM 822 1091 Cytoplasmic (Potential). FT METAL 295 295 Magnesium 1 (By similarity). FT METAL 295 295 Magnesium 2 (By similarity). FT METAL 296 296 Magnesium 2; via carbonyl oxygen (By FT similarity). FT METAL 339 339 Magnesium 1 (By similarity). FT METAL 339 339 Magnesium 2 (By similarity). FT CARBOHYD 713 713 N-linked (GlcNAc...) (Potential). FT CARBOHYD 716 716 N-linked (GlcNAc...) (Potential). FT VARIANT 147 147 V -> L (in dbSNP:rs13166360). FT /FTId=VAR_029012. FT VARIANT 163 163 V -> I (in dbSNP:rs34043481). FT /FTId=VAR_048247. FT CONFLICT 188 207 VWQILANVIIFICGNLAGAY -> GLADPGQCDHFHLWEPG FT XTN (in Ref. 1; AAP97285). FT CONFLICT 675 675 R -> Q (in Ref. 4; CAA52282/AAA64923). SQ SEQUENCE 1091 AA; 123603 MW; 41FD8BC607C075D1 CRC64; MWQEAMRRRR YLRDRSEEAA GGGDGLPRSR DWLYESYYCM SQQHPLIVFL LLIVMGSCLA LLAVFFALGL EVEDHVAFLI TVPTALAIFF AIFILVCIES VFKKLLRLFS LVIWICLVAM GYLFMCFGGT VSPWDQVSFF LFIIFVVYTM LPFNMRDAII ASVLTSSSHT IVLSVCLSAT PGGKEHLVWQ ILANVIIFIC GNLAGAYHKH LMELALQQTY QDTCNCIKSR IKLEFEKRQQ ERLLLSLLPA HIAMEMKAEI IQRLQGPKAG QMENTNNFHN LYVKRHTNVS ILYADIVGFT RLASDCSPGE LVHMLNELFG KFDQIAKENE CMRIKILGDC YYCVSGLPIS LPNHAKNCVK MGLDMCEAIK KVRDATGVDI NMRVGVHSGN VLCGVIGLQK WQYDVWSHDV TLANHMEAGG VPGRVHISSV TLEHLNGAYK VEEGDGDIRD PYLKQHLVKT YFVINPKGER RSPQHLFRPR HTLDGAKMRA SVRMTRYLES WGAAKPFAHL HHRDSMTTEN GKISTTDVPM GQHNFQNRTL RTKSQKKRFE EELNERMIQA IDGINAQKQW LKSEDIQRIS LLFYNKVLEK EYRATALPAF KYYVTCACLI FFCIFIVQIL VLPKTSVLGI SFGAAFLLLA FILFVCFAGQ LLQCSKKASP LLMWLLKSSG IIANRPWPRI SLTIITTAII LMMAVFNMFF LSDSEETIPP TANTTNTSFS ASNNQVAILR AQNLFFLPYF IYSCILGLIS CSVFLRVNYE LKMLIMMVAL VGYNTILLHT HAHVLGDYSQ VLFERPGIWK DLKTMGSVSL SIFFITLLVL GRQNEYYCRL DFLWKNKFKK EREEIETMEN LNRVLLENVL PAHVAEHFLA RSLKNEELYH QSYDCVCVMF ASIPDFKEFY TESDVNKEGL ECLRLLNEII ADFDDLLSKP KFSGVEKIKT IGSTYMAATG LSAVPSQEHS QEPERQYMHI GTMVEFAFAL VGKLDAINKH SFNDFKLRVG INHGPVIAGV IGAQKPQYDI WGNTVNVASR MDSTGVLDKI QVTEETSLVL QTLGYTCTCR GIINVKGKGD LKTYFVNTEM SRSLSQSNVA S //