ID CALB2_MOUSE Reviewed; 271 AA. AC Q08331; Q60964; Q9JM81; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 27-APR-2001, sequence version 3. DT 11-NOV-2015, entry version 120. DE RecName: Full=Calretinin; DE Short=CR; GN Name=Calb2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RA Tanaka Y., Taki K., Eguchi N., Kaneko T.; RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP NUCLEOTIDE SEQUENCE OF 1-31. RC STRAIN=129/Sv; RX PubMed=9387877; DOI=10.1016/S0169-328X(97)00143-5; RA Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I., Hammer M., RA Jacobowitz D.M.; RT "The mouse calretinin gene promoter region: structural and functional RT components."; RL Brain Res. Mol. Brain Res. 49:175-187(1997). RN [4] RP PROTEIN SEQUENCE OF 27-50; 124-133; 179-189 AND 234-244, AND RP IDENTIFICATION BY MASS SPECTROMETRY. RC STRAIN=OF1; TISSUE=Hippocampus; RA Lubec G., Klug S., Sunyer B., Chen W.-Q.; RL Submitted (JAN-2009) to UniProtKB. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 82-271. RX PubMed=8255773; DOI=10.1093/nar/21.22.5171; RA Ellis J., Rogers J.; RT "Design and specificity of hammerhead ribozymes against calretinin RT mRNA."; RL Nucleic Acids Res. 21:5171-5178(1993). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brain; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Calretinin is a calcium-binding protein which is CC abundant in auditory neurons. CC -!- SIMILARITY: Belongs to the calbindin family. {ECO:0000305}. CC -!- SIMILARITY: Contains 6 EF-hand domains. {ECO:0000255|PROSITE- CC ProRule:PRU00448}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB037969; BAA90701.1; -; Genomic_DNA. DR EMBL; BC017646; AAH17646.1; -; mRNA. DR EMBL; U34818; AAA84429.1; -; Genomic_DNA. DR EMBL; X73985; CAA52163.1; -; mRNA. DR CCDS; CCDS22661.1; -. DR PIR; S41476; S41476. DR RefSeq; NP_031612.1; NM_007586.1. DR UniGene; Mm.2755; -. DR ProteinModelPortal; Q08331; -. DR SMR; Q08331; 10-267. DR BioGrid; 198450; 1. DR IntAct; Q08331; 2. DR STRING; 10090.ENSMUSP00000003754; -. DR PhosphoSite; Q08331; -. DR UCD-2DPAGE; Q08331; -. DR MaxQB; Q08331; -. DR PaxDb; Q08331; -. DR PRIDE; Q08331; -. DR Ensembl; ENSMUST00000003754; ENSMUSP00000003754; ENSMUSG00000003657. DR GeneID; 12308; -. DR KEGG; mmu:12308; -. DR UCSC; uc009nko.1; mouse. DR CTD; 794; -. DR MGI; MGI:101914; Calb2. DR eggNOG; KOG0027; Eukaryota. DR eggNOG; COG5126; LUCA. DR GeneTree; ENSGT00390000013118; -. DR HOGENOM; HOG000231866; -. DR HOVERGEN; HBG000855; -. DR InParanoid; Q08331; -. DR OMA; TYRKSVM; -. DR OrthoDB; EOG71G9VB; -. DR PhylomeDB; Q08331; -. DR TreeFam; TF325083; -. DR NextBio; 280848; -. DR PRO; PR:Q08331; -. DR Proteomes; UP000000589; Chromosome 8. DR Bgee; Q08331; -. DR CleanEx; MM_CALB2; -. DR Genevisible; Q08331; MM. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005921; C:gap junction; IDA:MGI. DR GO; GO:0043005; C:neuron projection; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0045202; C:synapse; IBA:GO_Central. DR GO; GO:0043195; C:terminal bouton; IEA:Ensembl. DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central. DR GO; GO:0051480; P:cytosolic calcium ion homeostasis; IBA:GO_Central. DR Gene3D; 1.10.238.10; -; 2. DR InterPro; IPR029646; CALB2. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR PANTHER; PTHR19972:SF4; PTHR19972:SF4; 1. DR Pfam; PF00036; EF-hand_1; 1. DR Pfam; PF13499; EF-hand_7; 2. DR SMART; SM00054; EFh; 5. DR PROSITE; PS00018; EF_HAND_1; 5. DR PROSITE; PS50222; EF_HAND_2; 5. PE 1: Evidence at protein level; KW Calcium; Complete proteome; Direct protein sequencing; Metal-binding; KW Phosphoprotein; Reference proteome; Repeat. FT CHAIN 1 271 Calretinin. FT /FTId=PRO_0000073480. FT DOMAIN 16 51 EF-hand 1. {ECO:0000255|PROSITE- FT ProRule:PRU00448}. FT DOMAIN 63 98 EF-hand 2. {ECO:0000255|PROSITE- FT ProRule:PRU00448}. FT DOMAIN 107 142 EF-hand 3. {ECO:0000255|PROSITE- FT ProRule:PRU00448}. FT DOMAIN 151 186 EF-hand 4. {ECO:0000255|PROSITE- FT ProRule:PRU00448}. FT DOMAIN 195 230 EF-hand 5. {ECO:0000255|PROSITE- FT ProRule:PRU00448}. FT DOMAIN 235 270 EF-hand 6. {ECO:0000255|PROSITE- FT ProRule:PRU00448}. FT CA_BIND 29 40 1. {ECO:0000305}. FT CA_BIND 76 87 2; possibly ancestral. {ECO:0000305}. FT CA_BIND 120 131 3. {ECO:0000305}. FT CA_BIND 164 175 4. {ECO:0000305}. FT CA_BIND 208 219 5. {ECO:0000305}. FT CA_BIND 251 262 6; possibly ancestral. {ECO:0000305}. FT MOD_RES 214 214 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P47728}. SQ SEQUENCE 271 AA; 31373 MW; C6376AD7130DAACD CRC64; MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL TTYRKSVMSL AEAGKLYRKD LEIVLCSEPP V //