ID MED7_YEAST STANDARD; PRT; 222 AA. AC Q08278; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE RNA polymerase II mediator complex protein MED7 (RNA polymerase II DE transcriptional regulation mediator 7). GN Name=MED7; OrderedLocusNames=YOL135C; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=S288c / FY1679; RX MEDLINE=97051593; PubMed=8896270; RX DOI=10.1002/(SICI)1097-0061(199609)12:10B<1053::AID-YEA993>3.3.CO;2-J; RA Aldea M., Piedrafita L., Casas C., Casamayor A., Khalid H., RA Balcells L., Arino J., Herrero E.; RT "Sequence analysis of a 12 801 bp fragment of the left arm of yeast RT chromosome XV containing a putative 6-phosphofructo-2-kinase gene, a RT gene for a possible glycophospholipid-anchored surface protein and six RT other open reading frames."; RL Yeast 12:1053-1058(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=S288c; RA Marsischky G., Rolfs A., Richardson A., Kane M., Baqui M., Taycher E., RA Hu Y., Vannberg F., Weger J., Kramer J., Moreira D., Kelley F., RA Zuo D., Raphael J., Hogle C., Jepson D., Williamson J., Camargo A., RA Gonzaga L., Vasconcelos A.T., Simpson A., Kolodner R., Harlow E., RA LaBaer J.; RT "Creation of the YFLEX clone resource: cloning of Saccharomyces RT cerevisiae ORFs in the Gateway recombinational cloning system."; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the RNA polymerase II holoenzyme and the CC mediator of activation subcomplex. CC -!- INTERACTION: CC P38633:SOH1; NbExp=1; IntAct=EBI-10674, EBI-17658; CC P43592:YFR008W; NbExp=1; IntAct=EBI-10674, EBI-22932; CC -!- SUBCELLULAR LOCATION: Nuclear (Probable). CC -!- SIMILARITY: Belongs to the MED7 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X95465; CAA64734.1; -; Genomic_DNA. DR EMBL; Z74877; CAA99156.1; -; Genomic_DNA. DR EMBL; AY692889; AAT92908.1; -; Genomic_DNA. DR PIR; S66832; S66832. DR PDB; 1YKE; X-ray; A/C=102-205. DR PDB; 1YKH; X-ray; A=102-205. DR IntAct; Q08278; -. DR GermOnline; 143557; -. DR Ensembl; YOL135C; Saccharomyces cerevisiae. DR SGD; S000005495; MED7. DR GO; GO:0000119; C:mediator complex; IDA. DR GO; GO:0016455; F:RNA polymerase II transcription mediator ac...; IDA. DR GO; GO:0006366; P:transcription from RNA polymerase II promoter; IDA. DR InterPro; IPR009244; MED7. DR Pfam; PF05983; MED7; 1. KW 3D-structure; Complete proteome; Nuclear protein; Transcription; KW Transcription regulation. SQ SEQUENCE 222 AA; 25585 MW; A88301E4EF3223C9 CRC64; MSNDPGNEVS SLYPPPPPYV KFFTQSNLEK LPKYKEKKAA SAKQTAPNNS NGGSEEEITC ALDYLIPPPM PKNQQYRAFG SIWQVKDQLP DLESMGLTQL YKKSTENEST NYQYKIQELR KLLKSLLLNY LELIGVLSIN PDMYERKVEN IRTILVNIHH LLNEYRPHQS RESLIMLLEE QLEYKRGEIR EIEQVCKQVH DKLTSIQDTL RTGSQSPPSS SQ //