ID RGS1_HUMAN STANDARD; PRT; 196 AA. AC Q08116; Q07918; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE) DE REGULATOR OF G-PROTEIN SIGNALING 1 (RGS1) (EARLY RESPONSE PROTEIN DE 1R20) (B-CELL ACTIVATION PROTEIN BL34). GN RGS1 OR 1R20 OR BL34. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC PRIMATES; CATARRHINI; HOMINIDAE; HOMO. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=B-CELL; RX MEDLINE; 94060109. RA NEWTON J.S., DEED R.W., MITCHELL E.L.D., MURPHY J.J., NORTON J.D.; RT "A B cell specific immediate early human gene is located on RT chromosome band 1q31 and encodes an alpha helical basic RT phosphoprotein."; RL BIOCHIM. BIOPHYS. ACTA 1216:314-316(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=B-CELL; RX MEDLINE; 93232596. RA HONG J.X., WILSON G.L., FOX C.H., KEHRL J.H.; RT "Isolation and characterization of a novel B cell activation gene."; RL J. IMMUNOL. 150:3895-3904(1993). CC -!- FUNCTION: INHIBITS SIGNAL TRANSDUCTION BY INCREASING THE GTPASE CC ACTIVITY OF G PROTEIN ALPHA SUBUNITS THEREBY DRIVING THEM INTO CC THEIR INACTIVE GDP-BOUND FORM. THIS PROTEIN MAY BE INVOLVED IN THE CC REGULATION OF B-CELL ACTIVATION AND PROLIFERATION. CC -!- TISSUE SPECIFICITY: B-CELL SPECIFIC. EXPRESSION IS RELATIVELY LOW CC IN B CELLS AND CHRONIC LYMPHOCYTIC LEUKEMIA B CELLS; HOWEVER, IN CC OTHER TYPES OF MALIGNANT B CELL SUCH AS NON-HODGKIN'S LYMPHOMA AND CC HAIRY CELL LEUKEMIA, EXPRESSION IS CONSTITUTIVELY HIGH. CC -!- INDUCTION: IN RESPONSE TO SEVERAL B-CELL ACTIVATION SIGNALS. CC -!- PTM: COULD BE PHOSPHORYLATED. MIGHT BE FUNCTIONALLY REGULATED BY CC PROTEIN KINASE(S). CC -!- SIMILARITY: BELONGS TO THE RGS FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X73427; G313215; -. DR EMBL; S59049; G299705; -. DR PIR; S34157; S34157. DR PIR; S43436; S43436. DR MIM; 600323; -. DR PFAM; PF00615; RGS; 1. DR HSSP; P49799; 1AGR. KW SIGNAL TRANSDUCTION INHIBITOR; B-CELL ACTIVATION; PHOSPHORYLATION. FT DOMAIN 72 187 RGS. FT MOD_RES 19 19 PHOSPHORYLATION (BY CK2) (POTENTIAL). FT MOD_RES 54 54 PHOSPHORYLATION (BY PKC) (POTENTIAL). FT MOD_RES 62 62 PHOSPHORYLATION (BY CK2) (POTENTIAL). FT MOD_RES 146 146 PHOSPHORYLATION (BY PKC) (POTENTIAL). FT MOD_RES 156 156 PHOSPHORYLATION (BY CK2) (POTENTIAL). FT MOD_RES 167 167 PHOSPHORYLATION (BY CK2) (POTENTIAL). FT MOD_RES 194 194 PHOSPHORYLATION (BY PKC) (POTENTIAL). FT CONFLICT 181 181 H -> D (IN REF. 2). SQ SEQUENCE 196 AA; 22497 MW; 45C1C9FE CRC32; MPGMFFSANP KELKGTTHSL LDDKMQKRRP KTFGMDMKAY LRSMIPHLES GMKSSKSKDV LSAAEVMQWS QSLEKLLANQ TGQNVFGSFL KSEFSEENIE FWLACEDYKK TESDLLPCKA EEIYKAFVHS DAAKQINIDF RTRESTAKKI KAPTPTCFDE AQKVIYTLME KDSYPRFLKS HIYLNLLNDL QANSLK //