ID CP24_HUMAN STANDARD; PRT; 513 AA. AC Q07973; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE CYTOCHROME P450-CC24, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-) (P450- DE CC24) (VITAMIN D(3) 24-HYDROXYLASE) (1,25-DIHYDROXYVITAMIN D(3) 24- DE HYDROXYLASE) (24-OHASE). GN CYP24. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93281615; PubMed=8506296; RA Chen K.-S., Prahl J.M., Deluca H.F.; RT "Isolation and expression of human 1,25-dihydroxyvitamin D3 24- RT hydroxylase cDNA."; RL Proc. Natl. Acad. Sci. U.S.A. 90:4543-4547(1993). RN [2] RP SEQUENCE OF 257-513 FROM N.A. RX MEDLINE=94091187; PubMed=8266831; RA Labuda M., Lemieux N., Tihy F., Prinster C., Glorieux F.H.; RT "Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit RT maps to a different chromosomal location than that of pseudovitamin RT D-deficient rickets."; RL J. Bone Miner. Res. 8:1397-1406(1993). CC -!- FUNCTION: HAS A ROLE IN MAINTAINING CALCIUM HOMEOSTASIS. CATALYZES CC THE NADPH-DEPENDENT 24-HYDROXYLATION OF 25-HYDROXYVITAMIN D(3) IN CC THE PRESENCE OF ADRENODOXIN AND NADPH-ADRENODOXIN REDUCTASE. CC -!- SUBCELLULAR LOCATION: MITOCHONDRIAL. CC -!- SIMILARITY: BELONGS TO THE CYTOCHROME P450 FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L13286; AAA62379.1; -. DR EMBL; S67623; AAB29308.1; -. DR MIM; 126065; -. DR InterPro; IPR001128; -. DR InterPro; IPR002399; -. DR InterPro; IPR002949; -. DR Pfam; PF00067; p450; 1. DR PRINTS; PR00385; P450. DR PRINTS; PR00408; MITP450. DR PRINTS; PR01238; MITP450CC24. DR PROSITE; PS00086; CYTOCHROME_P450; 1. KW Oxidoreductase; Monooxygenase; Electron transport; Heme; KW Mitochondrion; Transit peptide. FT TRANSIT 1 35 MITOCHONDRION (BY SIMILARITY). FT CHAIN 36 513 CYTOCHROME P450-CC24. FT BINDING 461 461 HEME (POTENTIAL). FT CONFLICT 269 269 G -> D (IN REF. 2). FT CONFLICT 364 364 R -> V (IN REF. 2). FT CONFLICT 367 367 E -> A (IN REF. 2). FT CONFLICT 389 389 G -> S (IN REF. 2). FT CONFLICT 510 510 F -> S (IN REF. 2). SQ SEQUENCE 513 AA; 58781 MW; D8C04DE89F4E4E97 CRC64; MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG ETQNAAALPG PTSWPLLASL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR TESVPQRLEI KPWKAYRDYR KEGYGLLILE GEDWQRVRSA FQKKLMKPGE VMKLDNKINE VLADFMGRID ELCDERGHVE DLYSELNKWS FESICLVLYE KRFGLLQKNA GDEAVNFIMA IKTMMSTFGR MMVTPVELHK SLNTKVWQGH TLAWDTIFKS VKACIDNRLE KYSQQPSADF LCDIYHQNRL SKKELYAAVT ELQLAAVETT ANSLMWILYN LSRNPQVQQK LLKEIQSVLP ENQRPREEDL RNMPYLKACL KESMRLTPGV PFTTRTLDKA TVLGEYALPK GTVLMLNTQV LGSSEDNFED SSQFRPERWL QEKEKINPFA HLPFGVGKRM CIGRRLAELQ LHLALCWIVR KYDIQATDNE PVEMLHSGTL VPSRELPIAF CQR //