ID 16D10_MELHA Reviewed; 43 AA. AC Q06JG4; DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot. DT 31-OCT-2006, sequence version 1. DT 25-MAY-2022, entry version 17. DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 16D10; DE Flags: Precursor; GN Name=16D10; OS Meloidogyne hapla (Root-knot nematode worm). OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Tylenchina; Tylenchomorpha; Tylenchoidea; Meloidogynidae; Meloidogyninae; OC Meloidogyne. OX NCBI_TaxID=6305; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION. RX PubMed=16985000; DOI=10.1073/pnas.0604698103; RA Huang G., Allen R., Davis E.L., Baum T.J., Hussey R.S.; RT "Engineering broad root-knot resistance in transgenic plants by RNAi RT silencing of a conserved and essential root-knot nematode parasitism RT gene."; RL Proc. Natl. Acad. Sci. U.S.A. 103:14302-14306(2006). RN [2] RP REVIEW. RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010; RA Mitchum M.G., Wang X., Davis E.L.; RT "Diverse and conserved roles of CLE peptides."; RL Curr. Opin. Plant Biol. 11:75-81(2008). CC -!- FUNCTION: Plays a role in the differentiation or division of feeding CC cells (syncytia) induced in plant roots during infection. Promotes host CC root growth. {ECO:0000269|PubMed:16985000}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cytoplasm CC {ECO:0000250}. Host extracellular space {ECO:0000250}. Note=Secreted CC into host root cells via the nematode stylet to transform the recipient CC cells into enlarged multinucleate feeding cells called giant-cells or CC syncytia. {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Highly expressed exclusively within the subventral CC esophageal gland cell during syncytium formation in host plants. CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ841123; ABI33933.1; -; Genomic_DNA. DR AlphaFoldDB; Q06JG4; -. DR Proteomes; UP000095281; Whole Genome Shotgun Assembly. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0043655; C:host extracellular space; IEA:UniProtKB-SubCell. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. PE 2: Evidence at transcript level; KW Differentiation; Host cytoplasm; Secreted; Signal. FT SIGNAL 1..30 FT /evidence="ECO:0000255" FT CHAIN 31..43 FT /note="CLAVATA3/ESR (CLE)-related protein 16D10" FT /id="PRO_0000401219" FT MOTIF 31..43 FT /note="CLE" SQ SEQUENCE 43 AA; 4625 MW; CC5E0C37E220AF2E CRC64; MFTNSIKNLI IYLMPLMVTL MLLSVSFVDA GKKPSGPNPG GNN //