ID PDR8_YEAST Reviewed; 701 AA. AC Q06149; DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 01-MAY-2007, entry version 49. DE Transcription factor PDR8 (Pleiotropic drug resistance protein 8). GN Name=PDR8; OrderedLocusNames=YLR266C; ORFNames=L8479.13; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204511 / S288c / AB972; RX MEDLINE=97313267; PubMed=9169871; RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., RA Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., RA Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., RA Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., RA Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., RA Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., RA Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., RA Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., RA Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., RA Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., RA Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., RA Hani J., Hoheisel J.D.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."; RL Nature 387:87-90(1997). RN [2] RP FUNCTION. RX PubMed=12529331; DOI=10.1074/jbc.M208549200; RA Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.; RT "A general strategy to uncover transcription factor properties RT identifies a new regulator of drug resistance in yeast."; RL J. Biol. Chem. 278:11427-11432(2003). RN [3] RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. RX MEDLINE=22923954; PubMed=14562095; DOI=10.1038/nature02026; RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., RA Weissman J.S., O'Shea E.K.; RT "Global analysis of protein localization in budding yeast."; RL Nature 425:686-691(2003). CC -!- FUNCTION: Up-regulates the transcription of the genes for ATP- CC binding cassette (ABC) transporters YOR1 and PDR15, for major CC facilitator superfamily transporter AZR1, for pleiotropic drug CC resistance SNG1, for alpha-glucosidase YJL216C and for YLL056C. CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. CC -!- SIMILARITY: Contains 1 Zn(2)-C6 fungal-type DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U17244; AAB67383.1; -; Genomic_DNA. DR PIR; S51403; S51403. DR HSSP; P12351; 1PYC. DR DIP; DIP:1571N; -. DR Ensembl; YLR266C; Saccharomyces cerevisiae. DR GenomeReviews; Y13138_GR; YLR266C. DR KEGG; sce:YLR266C; -. DR CYGD; YLR266c; -. DR SGD; S000004256; PDR8. DR BioCyc; SCER-S28-01:SCER-S28-01-004154-MONOMER; -. DR LinkHub; Q06149; -. DR GermOnline; YLR266C; Saccharomyces cerevisiae. DR GO; GO:0005634; C:nucleus; IPI:SGD. DR GO; GO:0003677; F:DNA binding; IDA:SGD. DR GO; GO:0045944; P:positive regulation of transcription from R...; IGI:SGD. DR GO; GO:0006950; P:response to stress; IGI:SGD. DR InterPro; IPR007219; Fungal_trans. DR InterPro; IPR001138; Fungi_Trscrp_N. DR Gene3D; G3DSA:4.10.240.10; G3DSA:4.10.240.10; 1. DR Pfam; PF04082; Fungal_trans; 1. DR Pfam; PF00172; Zn_clus; 1. DR PRINTS; PR00054; FUNGALZNCYS. DR SMART; SM00066; GAL4; 1. DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1. DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1. KW Activator; Complete proteome; DNA-binding; Metal-binding; KW Nuclear protein; Transcription; Transcription regulation; Zinc. FT CHAIN 1 701 Transcription factor PDR8. FT /FTId=PRO_0000114963. FT DNA_BIND 31 59 Zn(2)-C6 fungal-type. FT COMPBIAS 272 278 Poly-Ser. SQ SEQUENCE 701 AA; 81274 MW; 78C8A82BDFD65F0E CRC64; MDGSHFPMKS TTGEPVSSGK KGKRRKVIKS CAFCRKRKLK CSQARPMCQQ CVIRKLPQCV YTEEFNYPLS NTELFEQVPN VALVQKIENL QTLLKENDNN NAKPVYCRSS ENPLRSLRTS VLGDNGSRYV FGPTSWKTLS LFEQNKFQTE FQNLWKVLKP LPECTKSQLN ENDVVADLPS FPQMESCIKS FFAGPLFGIL HIFNQDDILS LLDRLFIRDT TDKNLVILLD LQGNAKDKYN LGIVLQILCL GYYNQDIPSS VSHFLHTLSA ASLSSSSSNF VEKLQFFLLS YISVMINCTD GVWDATQGVD LINELCQGCI SLGLNDIDKW YLNESEETKQ NLRCIWFWAL FLDVSTSYDI GNPPSISDDL LDLSIFTAQN FQSPSIDFRR VKLMHDFLDV SRFTTREIHK REMNEKLTTF SLRLIEFIQS NFSPIEHYTN SVYYSDIDPF DILILSRSLS IVASIYNIEM IIAQQSRIID KNRMVQFLLI SISVCVNTMV FHFKEPINDQ ENVLTEGLKL SIILINPLLI RIVSQVYSLA FNRLIFREKA FLFLIDLDTG KKIQFIKYEE ENFDELLTGF DVRTDKFLSF SGTIIRFYEI IDSIFAVNER NKRLLKAVSN FYQLTSTLAF ERVSRVLFDK ASQARIETEK IWLKKGINME HFSDLMIEDF INDVWKTFKE ISKDLWSIDK KKFYKQYHFD L //