ID PDR8_YEAST Reviewed; 701 AA. AC Q06149; D6VYR4; DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 02-JUN-2021, entry version 153. DE RecName: Full=Transcription factor PDR8; DE AltName: Full=Pleiotropic drug resistance protein 8; GN Name=PDR8; OrderedLocusNames=YLR266C; ORFNames=L8479.13; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9169871; RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J., RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., RA Zollner A., Hani J., Hoheisel J.D.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."; RL Nature 387:87-90(1997). RN [2] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [3] RP FUNCTION. RX PubMed=12529331; DOI=10.1074/jbc.m208549200; RA Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.; RT "A general strategy to uncover transcription factor properties identifies a RT new regulator of drug resistance in yeast."; RL J. Biol. Chem. 278:11427-11432(2003). RN [4] RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. RX PubMed=14562095; DOI=10.1038/nature02026; RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., RA Weissman J.S., O'Shea E.K.; RT "Global analysis of protein localization in budding yeast."; RL Nature 425:686-691(2003). CC -!- FUNCTION: Up-regulates the transcription of the genes for ATP-binding CC cassette (ABC) transporters YOR1 and PDR15, for major facilitator CC superfamily transporter AZR1, for pleiotropic drug resistance SNG1, for CC alpha-glucosidase YJL216C and for YLL056C. CC {ECO:0000269|PubMed:12529331}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus CC {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U17244; AAB67383.1; -; Genomic_DNA. DR EMBL; BK006945; DAA09580.1; -; Genomic_DNA. DR PIR; S51403; S51403. DR RefSeq; NP_013368.1; NM_001182153.1. DR SMR; Q06149; -. DR BioGRID; 31534; 116. DR DIP; DIP-1571N; -. DR IntAct; Q06149; 2. DR MINT; Q06149; -. DR STRING; 4932.YLR266C; -. DR PaxDb; Q06149; -. DR PRIDE; Q06149; -. DR EnsemblFungi; YLR266C_mRNA; YLR266C; YLR266C. DR GeneID; 850971; -. DR KEGG; sce:YLR266C; -. DR SGD; S000004256; PDR8. DR VEuPathDB; FungiDB:YLR266C; -. DR eggNOG; ENOG502R710; Eukaryota. DR HOGENOM; CLU_010594_1_0_1; -. DR InParanoid; Q06149; -. DR OMA; WYLNESE; -. DR PRO; PR:Q06149; -. DR Proteomes; UP000002311; Chromosome XII. DR RNAct; Q06149; protein. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IDA:SGD. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:SGD. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:SGD. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR CDD; cd00067; GAL4; 1. DR Gene3D; 4.10.240.10; -; 1. DR InterPro; IPR007219; Transcription_factor_dom_fun. DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd. DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf. DR Pfam; PF04082; Fungal_trans; 1. DR Pfam; PF00172; Zn_clus; 1. DR SMART; SM00066; GAL4; 1. DR SUPFAM; SSF57701; SSF57701; 1. DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1. DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1. PE 1: Evidence at protein level; KW Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; KW Reference proteome; Transcription; Transcription regulation; Zinc. FT CHAIN 1..701 FT /note="Transcription factor PDR8" FT /id="PRO_0000114963" FT DNA_BIND 31..59 FT /note="Zn(2)-C6 fungal-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 701 AA; 81274 MW; 78C8A82BDFD65F0E CRC64; MDGSHFPMKS TTGEPVSSGK KGKRRKVIKS CAFCRKRKLK CSQARPMCQQ CVIRKLPQCV YTEEFNYPLS NTELFEQVPN VALVQKIENL QTLLKENDNN NAKPVYCRSS ENPLRSLRTS VLGDNGSRYV FGPTSWKTLS LFEQNKFQTE FQNLWKVLKP LPECTKSQLN ENDVVADLPS FPQMESCIKS FFAGPLFGIL HIFNQDDILS LLDRLFIRDT TDKNLVILLD LQGNAKDKYN LGIVLQILCL GYYNQDIPSS VSHFLHTLSA ASLSSSSSNF VEKLQFFLLS YISVMINCTD GVWDATQGVD LINELCQGCI SLGLNDIDKW YLNESEETKQ NLRCIWFWAL FLDVSTSYDI GNPPSISDDL LDLSIFTAQN FQSPSIDFRR VKLMHDFLDV SRFTTREIHK REMNEKLTTF SLRLIEFIQS NFSPIEHYTN SVYYSDIDPF DILILSRSLS IVASIYNIEM IIAQQSRIID KNRMVQFLLI SISVCVNTMV FHFKEPINDQ ENVLTEGLKL SIILINPLLI RIVSQVYSLA FNRLIFREKA FLFLIDLDTG KKIQFIKYEE ENFDELLTGF DVRTDKFLSF SGTIIRFYEI IDSIFAVNER NKRLLKAVSN FYQLTSTLAF ERVSRVLFDK ASQARIETEK IWLKKGINME HFSDLMIEDF INDVWKTFKE ISKDLWSIDK KKFYKQYHFD L //