ID FAR10_YEAST Reviewed; 478 AA. AC Q06001; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 02-MAR-2010, entry version 68. DE RecName: Full=Factor arrest protein 10; GN Name=FAR10; OrderedLocusNames=YLR238W; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; OC Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204511 / S288c / AB972; RX MEDLINE=97313267; PubMed=9169871; RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., RA Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., RA Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., RA Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., RA Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., RA Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., RA Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., RA Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., RA Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., RA Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., RA Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., RA Hani J., Hoheisel J.D.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."; RL Nature 387:87-90(1997). RN [2] RP SUBCELLULAR LOCATION. RX PubMed=12514182; DOI=10.1074/jbc.M212725200; RA Beilharz T., Egan B., Silver P.A., Hofmann K., Lithgow T.; RT "Bipartite signals mediate subcellular targeting of tail-anchored RT membrane proteins in Saccharomyces cerevisiae."; RL J. Biol. Chem. 278:8219-8223(2003). RN [3] RP FUNCTION, AND INTERACTION WITH FAR3; FAR7; FAR8; FAR11 AND VPS64. RX PubMed=12588993; DOI=10.1128/MCB.23.5.1750-1763.2003; RA Kemp H.A., Sprague G.F. Jr.; RT "Far3 and five interacting proteins prevent premature recovery from RT pheromone arrest in the budding yeast Saccharomyces cerevisiae."; RL Mol. Cell. Biol. 23:1750-1763(2003). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419 AND THR-420, AND RP MASS SPECTROMETRY. RX PubMed=17287358; DOI=10.1073/pnas.0607084104; RA Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., RA Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; RT "Analysis of phosphorylation sites on proteins from Saccharomyces RT cerevisiae by electron transfer dissociation (ETD) mass RT spectrometry."; RL Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). CC -!- FUNCTION: Participates in the control of the reentry into the cell CC cycle following pheromone treatment. CC -!- SUBUNIT: Component of a complex at least composed of FAR3, FAR7, CC FAR8, FAR10, FAR11 and VPS64. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane CC protein (Potential). CC -!- SIMILARITY: Contains 1 FHA domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U19027; AAB67404.1; -; Genomic_DNA. DR PIR; S51457; S51457. DR RefSeq; NP_013339.1; -. DR SMR; Q06001; 75-197. DR DIP; DIP-1572N; -. DR IntAct; Q06001; 8. DR STRING; Q06001; -. DR PRIDE; Q06001; -. DR Ensembl; YLR238W; YLR238W; YLR238W; Saccharomyces cerevisiae. DR GeneID; 850939; -. DR GenomeReviews; Y13138_GR; YLR238W. DR KEGG; sce:YLR238W; -. DR NMPDR; fig|4932.3.peg.4352; -. DR CYGD; YLR238w; -. DR SGD; S000004228; FAR10. DR eggNOG; fuNOG04176; -. DR HOGENOM; HBG323805; -. DR OMA; TSPNLIN; -. DR OrthoDB; EOG9PCC86; -. DR PhylomeDB; Q06001; -. DR NextBio; 967384; -. DR ArrayExpress; Q06001; -. DR Genevestigator; Q06001; -. DR GermOnline; YLR238W; Saccharomyces cerevisiae. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0000321; P:re-entry into mitotic cell cycle after pher...; IGI:SGD. DR InterPro; IPR000253; FHA. DR InterPro; IPR008984; SMAD_FHA_domain. DR Gene3D; G3DSA:2.60.200.20; FHA; 1. DR Pfam; PF00498; FHA; 1. DR SMART; SM00240; FHA; 1. DR SUPFAM; SSF49879; SMAD_FHA; 1. DR PROSITE; PS50006; FHA_DOMAIN; 1. PE 1: Evidence at protein level; KW Cell cycle; Coiled coil; Complete proteome; Membrane; Phosphoprotein; KW Transmembrane. FT CHAIN 1 478 Factor arrest protein 10. FT /FTId=PRO_0000087189. FT TOPO_DOM 1 454 Cytoplasmic (Potential). FT TRANSMEM 455 475 Anchor for type IV membrane protein FT (Potential). FT TOPO_DOM 476 478 Extracellular (Potential). FT DOMAIN 116 176 FHA. FT COILED 342 426 Potential. FT COMPBIAS 108 115 Poly-Ser. FT MOD_RES 419 419 Phosphoserine. FT MOD_RES 420 420 Phosphothreonine. SQ SEQUENCE 478 AA; 54092 MW; A3A4B2B83C967DD0 CRC64; MTGPGPEINK EEHPSSPGKK QITYNSIPKN ANLIDGSTNS SKRPIEKYDK RIADPTKSYF PHSISRTPRR KYTYILVLTS LNGTFESKHV VIPFKPDGLK LGRPVANSNS SSSSSLRGGK RVDSHTFSQV RSDNGNFDSR VLSRNHALLS CDPLTGKVYI RDLKSSNGTF INGQRIGSND VEIKVGDVID LGTDIDTKIE HRKISATVEE LFVQPLLESP IFENEDSDDC HTITEKEEAA AITSHIYGDS NNLELEEVIL GSDTEILSGI FINNCIGTSP TLSNIIKTLA MEIPFSKCDN FKLQSMENFL INYTTHLEYT NKLLVEKNDQ QLVKLQNGLR RKLSGKYEKI IEQNRNQVKQ LERDHMFFKK SFEVKKRRNN EKQKSMEREI EDLKTRLEVE RYKNSQMMKK NKQKEQELST ASKKKTTEHD TRGVPGMNPK GTDKFSIKNT LCNHFTLLTF GTISIGIIAI VFKILSPN //