ID   FAR10_YEAST             Reviewed;         478 AA.
AC   Q06001; D6VYN6;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-OCT-2024, entry version 162.
DE   RecName: Full=Factor arrest protein 10;
GN   Name=FAR10; OrderedLocusNames=YLR238W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871; DOI=10.1038/387s087;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=12514182; DOI=10.1074/jbc.m212725200;
RA   Beilharz T., Egan B., Silver P.A., Hofmann K., Lithgow T.;
RT   "Bipartite signals mediate subcellular targeting of tail-anchored membrane
RT   proteins in Saccharomyces cerevisiae.";
RL   J. Biol. Chem. 278:8219-8223(2003).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH FAR3; FAR7; FAR8; FAR11 AND VPS64.
RX   PubMed=12588993; DOI=10.1128/mcb.23.5.1750-1763.2003;
RA   Kemp H.A., Sprague G.F. Jr.;
RT   "Far3 and five interacting proteins prevent premature recovery from
RT   pheromone arrest in the budding yeast Saccharomyces cerevisiae.";
RL   Mol. Cell. Biol. 23:1750-1763(2003).
CC   -!- FUNCTION: Participates in the control of the reentry into the cell
CC       cycle following pheromone treatment. {ECO:0000269|PubMed:12588993}.
CC   -!- SUBUNIT: Component of a complex at least composed of FAR3, FAR7, FAR8,
CC       FAR10, FAR11 and VPS64.
CC   -!- INTERACTION:
CC       Q06001; P46671: FAR3; NbExp=2; IntAct=EBI-37631, EBI-6789;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}.
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DR   EMBL; U19027; AAB67404.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09552.1; -; Genomic_DNA.
DR   PIR; S51457; S51457.
DR   RefSeq; NP_013339.1; NM_001182125.1.
DR   AlphaFoldDB; Q06001; -.
DR   SMR; Q06001; -.
DR   BioGRID; 31505; 224.
DR   ComplexPortal; CPX-1197; FAR complex.
DR   DIP; DIP-1572N; -.
DR   IntAct; Q06001; 17.
DR   MINT; Q06001; -.
DR   STRING; 4932.YLR238W; -.
DR   iPTMnet; Q06001; -.
DR   PaxDb; 4932-YLR238W; -.
DR   PeptideAtlas; Q06001; -.
DR   EnsemblFungi; YLR238W_mRNA; YLR238W; YLR238W.
DR   GeneID; 850939; -.
DR   KEGG; sce:YLR238W; -.
DR   AGR; SGD:S000004228; -.
DR   SGD; S000004228; FAR10.
DR   VEuPathDB; FungiDB:YLR238W; -.
DR   eggNOG; KOG3872; Eukaryota.
DR   GeneTree; ENSGT00940000176673; -.
DR   HOGENOM; CLU_031992_1_0_1; -.
DR   InParanoid; Q06001; -.
DR   OMA; YLIVPFK; -.
DR   OrthoDB; 2787016at2759; -.
DR   BioCyc; YEAST:G3O-32347-MONOMER; -.
DR   BioGRID-ORCS; 850939; 0 hits in 10 CRISPR screens.
DR   PRO; PR:Q06001; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q06001; protein.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; NAS:ComplexPortal.
DR   GO; GO:0090443; C:FAR/SIN/STRIPAK complex; NAS:ComplexPortal.
DR   GO; GO:0071444; P:cellular response to pheromone; NAS:ComplexPortal.
DR   GO; GO:0000321; P:re-entry into mitotic cell cycle after pheromone arrest; IGI:SGD.
DR   GO; GO:0051726; P:regulation of cell cycle; NAS:ComplexPortal.
DR   CDD; cd22695; FHA_VPS64-like; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   InterPro; IPR051176; Cent_Immune-Sig_Mod.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR15715; CENTROSOMAL PROTEIN OF 170 KDA; 1.
DR   PANTHER; PTHR15715:SF37; LD47843P; 1.
DR   Pfam; PF00498; FHA; 1.
DR   SMART; SM00240; FHA; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..478
FT                   /note="Factor arrest protein 10"
FT                   /id="PRO_0000087189"
FT   TOPO_DOM        1..454
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        476..478
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          116..176
FT                   /note="FHA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          342..426
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        18..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..431
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   478 AA;  54092 MW;  A3A4B2B83C967DD0 CRC64;
     MTGPGPEINK EEHPSSPGKK QITYNSIPKN ANLIDGSTNS SKRPIEKYDK RIADPTKSYF
     PHSISRTPRR KYTYILVLTS LNGTFESKHV VIPFKPDGLK LGRPVANSNS SSSSSLRGGK
     RVDSHTFSQV RSDNGNFDSR VLSRNHALLS CDPLTGKVYI RDLKSSNGTF INGQRIGSND
     VEIKVGDVID LGTDIDTKIE HRKISATVEE LFVQPLLESP IFENEDSDDC HTITEKEEAA
     AITSHIYGDS NNLELEEVIL GSDTEILSGI FINNCIGTSP TLSNIIKTLA MEIPFSKCDN
     FKLQSMENFL INYTTHLEYT NKLLVEKNDQ QLVKLQNGLR RKLSGKYEKI IEQNRNQVKQ
     LERDHMFFKK SFEVKKRRNN EKQKSMEREI EDLKTRLEVE RYKNSQMMKK NKQKEQELST
     ASKKKTTEHD TRGVPGMNPK GTDKFSIKNT LCNHFTLLTF GTISIGIIAI VFKILSPN
//