ID FAR10_YEAST Reviewed; 478 AA. AC Q06001; D6VYN6; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 03-MAY-2023, entry version 156. DE RecName: Full=Factor arrest protein 10; GN Name=FAR10; OrderedLocusNames=YLR238W; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9169871; RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J., RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., RA Zollner A., Hani J., Hoheisel J.D.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."; RL Nature 387:87-90(1997). RN [2] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [3] RP SUBCELLULAR LOCATION. RX PubMed=12514182; DOI=10.1074/jbc.m212725200; RA Beilharz T., Egan B., Silver P.A., Hofmann K., Lithgow T.; RT "Bipartite signals mediate subcellular targeting of tail-anchored membrane RT proteins in Saccharomyces cerevisiae."; RL J. Biol. Chem. 278:8219-8223(2003). RN [4] RP FUNCTION, AND INTERACTION WITH FAR3; FAR7; FAR8; FAR11 AND VPS64. RX PubMed=12588993; DOI=10.1128/mcb.23.5.1750-1763.2003; RA Kemp H.A., Sprague G.F. Jr.; RT "Far3 and five interacting proteins prevent premature recovery from RT pheromone arrest in the budding yeast Saccharomyces cerevisiae."; RL Mol. Cell. Biol. 23:1750-1763(2003). CC -!- FUNCTION: Participates in the control of the reentry into the cell CC cycle following pheromone treatment. {ECO:0000269|PubMed:12588993}. CC -!- SUBUNIT: Component of a complex at least composed of FAR3, FAR7, FAR8, CC FAR10, FAR11 and VPS64. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV CC membrane protein {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U19027; AAB67404.1; -; Genomic_DNA. DR EMBL; BK006945; DAA09552.1; -; Genomic_DNA. DR PIR; S51457; S51457. DR RefSeq; NP_013339.1; NM_001182125.1. DR AlphaFoldDB; Q06001; -. DR SMR; Q06001; -. DR BioGRID; 31505; 220. DR ComplexPortal; CPX-1197; FAR complex. DR DIP; DIP-1572N; -. DR IntAct; Q06001; 12. DR MINT; Q06001; -. DR STRING; 4932.YLR238W; -. DR iPTMnet; Q06001; -. DR MaxQB; Q06001; -. DR PaxDb; Q06001; -. DR PeptideAtlas; Q06001; -. DR EnsemblFungi; YLR238W_mRNA; YLR238W; YLR238W. DR GeneID; 850939; -. DR KEGG; sce:YLR238W; -. DR AGR; SGD:S000004228; -. DR SGD; S000004228; FAR10. DR VEuPathDB; FungiDB:YLR238W; -. DR eggNOG; KOG3872; Eukaryota. DR GeneTree; ENSGT00940000176673; -. DR HOGENOM; CLU_031992_1_0_1; -. DR InParanoid; Q06001; -. DR OMA; HMAASNA; -. DR OrthoDB; 2787016at2759; -. DR BioCyc; YEAST:G3O-32347-MON; -. DR BioGRID-ORCS; 850939; 0 hits in 10 CRISPR screens. DR PRO; PR:Q06001; -. DR Proteomes; UP000002311; Chromosome XII. DR RNAct; Q06001; protein. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD. DR GO; GO:0005789; C:endoplasmic reticulum membrane; NAS:ComplexPortal. DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; NAS:ComplexPortal. DR GO; GO:0071444; P:cellular response to pheromone; NAS:ComplexPortal. DR GO; GO:0000321; P:re-entry into mitotic cell cycle after pheromone arrest; IGI:SGD. DR GO; GO:0051726; P:regulation of cell cycle; NAS:ComplexPortal. DR CDD; cd22695; FHA_VPS64-like; 1. DR Gene3D; 2.60.200.20; -; 1. DR InterPro; IPR000253; FHA_dom. DR InterPro; IPR008984; SMAD_FHA_dom_sf. DR PANTHER; PTHR15715; CENTROSOMAL PROTEIN OF 170 KDA; 1. DR PANTHER; PTHR15715:SF37; LD47843P; 1. DR Pfam; PF00498; FHA; 1. DR SMART; SM00240; FHA; 1. DR SUPFAM; SSF49879; SMAD/FHA domain; 1. DR PROSITE; PS50006; FHA_DOMAIN; 1. PE 1: Evidence at protein level; KW Cell cycle; Coiled coil; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..478 FT /note="Factor arrest protein 10" FT /id="PRO_0000087189" FT TOPO_DOM 1..454 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 455..475 FT /note="Helical; Anchor for type IV membrane protein" FT /evidence="ECO:0000255" FT TOPO_DOM 476..478 FT /note="Extracellular" FT /evidence="ECO:0000255" FT DOMAIN 116..176 FT /note="FHA" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086" FT REGION 1..45 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 101..129 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 405..443 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 342..426 FT /evidence="ECO:0000255" FT COMPBIAS 18..41 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 104..122 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 405..431 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 478 AA; 54092 MW; A3A4B2B83C967DD0 CRC64; MTGPGPEINK EEHPSSPGKK QITYNSIPKN ANLIDGSTNS SKRPIEKYDK RIADPTKSYF PHSISRTPRR KYTYILVLTS LNGTFESKHV VIPFKPDGLK LGRPVANSNS SSSSSLRGGK RVDSHTFSQV RSDNGNFDSR VLSRNHALLS CDPLTGKVYI RDLKSSNGTF INGQRIGSND VEIKVGDVID LGTDIDTKIE HRKISATVEE LFVQPLLESP IFENEDSDDC HTITEKEEAA AITSHIYGDS NNLELEEVIL GSDTEILSGI FINNCIGTSP TLSNIIKTLA MEIPFSKCDN FKLQSMENFL INYTTHLEYT NKLLVEKNDQ QLVKLQNGLR RKLSGKYEKI IEQNRNQVKQ LERDHMFFKK SFEVKKRRNN EKQKSMEREI EDLKTRLEVE RYKNSQMMKK NKQKEQELST ASKKKTTEHD TRGVPGMNPK GTDKFSIKNT LCNHFTLLTF GTISIGIIAI VFKILSPN //