ID UBIQ_LEIMA Reviewed; 76 AA. AC Q05550; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 01-MAY-2007, entry version 40. DE Ubiquitin. GN Name=UB-EP52; OS Leishmania major. OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania. OX NCBI_TaxID=5664; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=MHOM/IR/83/Lt252; RX MEDLINE=93380668; PubMed=8396548; DOI=10.1016/0378-1119(93)90687-X; RA Graeff G.R., Steele P.M., Peterson C.L., Bennett M.L., Langer P.J.; RT "Sequence of a Leishmania major gene encoding an ubiquitin fusion RT protein."; RL Gene 131:155-156(1993). CC -!- FUNCTION: Protein modifier which can be covalently attached to CC target lysines either as a monomer or as a lysine-linked polymer. CC Attachment to proteins as a Lys-48-linked polymer usually leads to CC their degradation by proteasome. Attachment to proteins as a CC monomer or as an alternatively linked polymer does not lead to CC proteasomal degradation and may be required for numerous CC fonctions, including maintenance of chromatin structure, CC regulation of gene expression, stress response, ribosome CC biogenesis and DNA repair (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. CC -!- MISCELLANEOUS: This protein is synthesized with ribosomal CEP52 as CC its C-terminal extension. CC -!- SIMILARITY: Belongs to the ubiquitin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z14232; CAA78598.1; -; Genomic_DNA. DR HSSP; P02248; 1GJZ. DR SMR; Q05550; 1-76. DR InterPro; IPR000626; Ubiquitin. DR Gene3D; G3DSA:3.10.20.90; G3DSA:3.10.20.90; 1. DR Pfam; PF00240; ubiquitin; 1. DR PRINTS; PR00348; UBIQUITIN. DR SMART; SM00213; UBQ; 1. DR PROSITE; PS00299; UBIQUITIN_1; 1. DR PROSITE; PS50053; UBIQUITIN_2; 1. KW Nuclear protein; Ubl conjugation. FT CHAIN 1 76 Ubiquitin. FT /FTId=PRO_0000114825. FT CROSSLNK 48 48 Glycyl lysine isopeptide (Lys-Gly) FT (interchain with G-Cter in FT multiubiquitin) (By similarity). FT CROSSLNK 76 76 Glycyl lysine isopeptide (Gly-Lys) FT (interchain with K-? in acceptor FT proteins) (By similarity). SQ SEQUENCE 76 AA; 8549 MW; C52648497FFD8E47 CRC64; MQIFVKTLTG KTIALEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EEGRTLSDYN IQKESTLHLV LRLRGG //