ID UBIQ_LEIMA STANDARD; PRT; 76 AA. AC Q05550; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 07-FEB-2006 (Rel. 49, Last annotation update) DE Ubiquitin. GN Name=UB-EP52; OS Leishmania major. OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania. OX NCBI_TaxID=5664; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=MHOM/IR/83/Lt252; RX MEDLINE=93380668; PubMed=8396548; DOI=10.1016/0378-1119(93)90687-X; RA Graeff G.R., Steele P.M., Peterson C.L., Bennett M.L., Langer P.J.; RT "Sequence of a Leishmania major gene encoding an ubiquitin fusion RT protein."; RL Gene 131:155-156(1993). CC -!- FUNCTION: Involved in the ATP-dependent selective degradation of CC cellular proteins, the maintenance of chromatin structure, the CC regulation of gene expression, the stress response, and ribosome CC biogenesis. CC -!- SUBCELLULAR LOCATION: Nuclear and cytoplasmic. CC -!- MISCELLANEOUS: This protein is synthesized with ribosomal CEP52 as CC its C-terminal extension. CC -!- SIMILARITY: Belongs to the ubiquitin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z14232; CAA78598.1; -; Genomic_DNA. DR HSSP; P02248; 1GJZ. DR SMR; Q05550; 1-76. DR InterPro; IPR000626; Ubiquitin. DR Pfam; PF00240; ubiquitin; 1. DR PRINTS; PR00348; UBIQUITIN. DR SMART; SM00213; UBQ; 1. DR PROSITE; PS00299; UBIQUITIN_1; 1. DR PROSITE; PS50053; UBIQUITIN_2; 1. KW Nuclear protein; Polyprotein; Ubl conjugation. FT CROSSLNK 48 48 Glycyl lysine isopeptide (Lys-Gly) FT (interchain with G-Cter in FT multiubiquitin) (By similarity). FT CROSSLNK 76 76 Glycyl lysine isopeptide (Gly-Lys) FT (interchain with K-? in acceptor FT proteins) (By similarity). SQ SEQUENCE 76 AA; 8549 MW; C52648497FFD8E47 CRC64; MQIFVKTLTG KTIALEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EEGRTLSDYN IQKESTLHLV LRLRGG //