ID UBIQ_LEIMA STANDARD; PRT; 76 AA. AC Q05550; DT 01-FEB-1994 (REL. 28, CREATED) DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE) DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE) DE UBIQUITIN. OS LEISHMANIA MAJOR. OC EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA; OC TRYPANOSOMATIDAE. RN [1] RP SEQUENCE FROM N.A. RM 93380668 RA GRAEFF G.R., STEELE P.M., PETERSON C.L., BENNETT M.L., LANGER P.J.; RL GENE 131:155-156(1993). CC -!- FUNCTION: INVOLVED IN THE ATP-DEPENDENT SELECTIVE DEGRADATION OF CC CELLULAR PROTEINS, THE MAINTENANCE OF CHROMATIN STRUCTURE, THE CC REGULATION OF GENE EXPRESSION, THE STRESS RESPONSE, AND RIBOSOME CC BIOGENESIS. CC -!- SUBCELLULAR LOCATION: BOTH NUCLEAR AND CYTOPLASMIC. CC -!- UBIQUITIN IS SYNTHESIZED AS A POLYUBIQUITIN PRECURSOR WITH EXACT CC HEAD TO TAIL REPEATS, THE NUMBER OF REPEAT DIFFER BETWEEN SPECIES. CC SOME UBIQUITIN GENES CONTAIN A SINGLE COPY OF UBIQUITIN FUSED TO A CC RIBOSOMAL PROTEIN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z14232; LMUBIQUTN. DR PROSITE; PS00299; UBIQUITIN. KW NUCLEAR PROTEIN; POLYPROTEIN. FT SITE 48 48 NECESSARY FOR BRANCHED-CHAIN FT BINDING 76 76 CONJUGATION TO ACCEPTOR PROTEINS. SQ SEQUENCE 76 AA; 8549 MW; 28015 CN; MQIFVKTLTG KTIALEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EEGRTLSDYN IQKESTLHLV LRLRGG //