ID UBIQ_LEIMA STANDARD; PRT; 76 AA. AC Q05550; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE UBIQUITIN. OS Leishmania major. OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=MHOM/IR/83/LT252; RX MEDLINE; 93380668. RA Graeff G.R., Steele P.M., Peterson C.L., Bennett M.L., Langer P.J.; RT "Sequence of a Leishmania major gene encoding an ubiquitin fusion RT protein."; RL Gene 131:155-156(1993). CC -!- FUNCTION: INVOLVED IN THE ATP-DEPENDENT SELECTIVE DEGRADATION OF CC CELLULAR PROTEINS, THE MAINTENANCE OF CHROMATIN STRUCTURE, THE CC REGULATION OF GENE EXPRESSION, THE STRESS RESPONSE, AND RIBOSOME CC BIOGENESIS. CC -!- SUBCELLULAR LOCATION: NUCLEAR AND CYTOPLASMIC. CC -!- MISCELLANEOUS: THIS PROTEIN IS SYNTHESIZED WITH RIBOSOMAL CEP52 AS CC ITS C-TERMINAL EXTENSION. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z14232; CAA78598.1; -. DR HSSP; P02248; 1AAR. DR INTERPRO; IPR000626; -. DR PFAM; PF00240; ubiquitin; 1. DR PRINTS; PR00348; UBIQUITIN. DR PROSITE; PS00299; UBIQUITIN_1; 1. DR PROSITE; PS50053; UBIQUITIN_2; 1. KW Nuclear protein; Polyprotein. FT SITE 48 48 NECESSARY FOR BRANCHED-CHAIN FT MULTIUBIQUITIN ADDUCTS. FT BINDING 76 76 CONJUGATION TO ACCEPTOR PROTEINS. SQ SEQUENCE 76 AA; 8549 MW; C52648497FFD8E47 CRC64; MQIFVKTLTG KTIALEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EEGRTLSDYN IQKESTLHLV LRLRGG //