ID SWR1_YEAST STANDARD; PRT; 1514 AA. AC Q05471; DT 15-JUL-1999 (Rel. 38, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 01-MAY-2005 (Rel. 47, Last annotation update) DE Helicase SWR1. GN Name=SWR1; OrderedLocusNames=YDR334W; ORFNames=D9651.6; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S288c / AB972; RX MEDLINE=97313263; PubMed=9169867; RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., RA Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., RA Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., RA Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., RA Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., RA Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., RA Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., RA Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., RA Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., RA Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., RA Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., RA Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., RA Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., RA Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., RA Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., RA Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., RA Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., RA Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., RA Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., RA Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., RA Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., RA Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., RA Waterston R., Albermann K., Hani J., Heumann K., Kleine K., RA Mewes H.-W., Zollner A., Zaccaria P.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."; RL Nature 387:75-78(1997). RN [2] RP FUNCTION. RX PubMed=14690608; DOI=10.1016/S1097-2765(03)00497-0; RA Krogan N.J., Keogh M.C., Datta N., Sawa C., Ryan O.W., Ding H., RA Haw R.A., Pootoolal J., Tong A., Canadien V., Richards D.P., Wu X., RA Emili A., Hughes T.R., Buratowski S., Greenblatt J.F.; RT "A Snf2 family ATPase complex required for recruitment of the histone RT H2A variant Htz1."; RL Mol. Cell 12:1565-1576(2003). CC -!- FUNCTION: Required for the incorporation of HTZ1 into chromatin. CC -!- SUBUNIT: Component of the SWR-C complex. CC -!- INTERACTION: CC P60010:ACT1; NbExp=1; IntAct=EBI-22102, EBI-2169; CC P35817:BDF1; NbExp=1; IntAct=EBI-22102, EBI-3493; CC Q12692:HTA3; NbExp=1; IntAct=EBI-22102, EBI-8080; CC P02293:HTB1; NbExp=1; IntAct=EBI-22102, EBI-8088; CC P53201:YGR002C; NbExp=1; IntAct=EBI-22102, EBI-23061; CC -!- SUBCELLULAR LOCATION: Nuclear (Potential). CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. CC -!- SIMILARITY: Contains 1 HSA domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U51032; AAB64770.1; -. DR PIR; S70099; S70099. DR IntAct; Q05471; -. DR GermOnline; 140826; -. DR Ensembl; YDR334W; Saccharomyces cerevisiae. DR SGD; S000002742; SWR1. DR GO; GO:0005634; C:nucleus; IDA. DR GO; GO:0000812; C:SWR1 complex; IPI. DR GO; GO:0006338; P:chromatin remodeling; IDA. DR InterPro; IPR001410; DEAD. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR006562; HSA. DR InterPro; IPR000330; SNF2_N. DR Pfam; PF00271; Helicase_C; 1. DR Pfam; PF07529; HSA; 1. DR Pfam; PF00176; SNF2_N; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. KW ATP-binding; Complete proteome; DNA-binding; Helicase; Hydrolase; KW Nuclear protein. FT DOMAIN 340 411 HSA. FT NP_BIND 721 728 ATP (Potential). FT SITE 824 827 DEGH box. SQ SEQUENCE 1514 AA; 174530 MW; 156E3BB5978905C8 CRC64; MTTSRKSHAK DKKAGGEQDL ADLKFRYDLL TNELFHLREF VSLVDYDPTH FNDSESFQKF LRETHLSLEE RGEKFTDDVA KKGTNGDLTR RRRNLRTSTV VSSETTNEKK GDIELKLESI APLVRNKCEE LKYKLSDHSN RKSIVPQKRP IQHLKKREAA KSLKFKSERK ENPLPLHEHI AEERYDHIAK VEEPSEAFTI KCPSDDSSFE NTSEHYSDNF YFTTSSEEED IKKKRGRKKK KPRIKLVVHP PKQTITNPLH VVKPGYESLH EYIASFKSLE DDLTLEEYNK YIDEQRRLLS RLKKGIENGA LKYDKETDSL QPITSKEIKT IITYKPDPIS YFYKQQDLQI HTDHLINQGI HMSKLFRSST KARIARAKKV SQMIEQHFKH VAGAEERKAK EEERHKKSLA RFAVQAVKKR WNMAEKAYRI LRKDEEEQLK RIEGKQHLSK MLEKSTQLLE AQLNQVNDDG RSSTPSSDSN DVLSESDDDM DDELSTSSDE DEEVDADVGL ENSPASTEAT PTDESLNLIQ LKEKYGHFNG SSTVYDSRNK DEKFPTLDKH ESSSSESSVM TGEESSIYSS SENESQNEND RESDDKTPSV GLSALFGKGE ESDGDLDLDD SEDFTVNSSS VEGEELEKDQ VDNSAATFER AGDFVHTQNE NRDDIKDVEE DAETKVQEEQ LSVVDVPVPS LLRGNLRTYQ KQGLNWLASL YNNHTNGILA DEMGLGKTIQ TISLLAYLAC EKENWGPHLI VVPTSVLLNW EMEFKRFAPG FKVLTYYGSP QQRKEKRKGW NKPDAFHVCI VSYQLVVQDQ HSFKRKRWQY MVLDEAHNIK NFRSTRWQAL LNFNTQRRLL LTGTPLQNNL AELWSLLYFL MPQTVIDGKK VSGFADLDAF QQWFGRPVDK IIETGQNFGQ DKETKKTVAK LHQVLRPYLL RRLKADVEKQ MPAKYEHIVY CKLSKRQRFL YDDFMSRAQT KATLASGNFM SIVNCLMQLR KVCNHPNLFE VRPILTSFVL EHCVASDYKD VERTLLKLFK KNNQVNRVDL DFLNLVFTLN DKDLTSYHAE EISKLTCVKN FVEEVNKLRE TNKQLQEEFG EASFLNFQDA NQYFKYSNKQ KLEGTVDMLN FLKMVNKLRC DRRPIFGKNL IDLLTKDRRV KYDKSSIIDN ELIKPLQTRV LDNRKIIDTF AVLTPSAVSL DMRKLALGLN DDSSVGENTR LKVMQNCFEV SNPLHQLQTK LTIAFPDKSL LQYDCGKLQK LAILLQQLKD NGHRALIFTQ MTKVLDVLEQ FLNYHGYLYM RLDGATKIED RQILTERFNT DSRITVFILS SRSGGLGINL TGADTVIFYD SDWNPAMDKQ CQDRCHRIGQ TRDVHIYRFV SEHTIESNIL KKANQKRQLD NVVIQEGDFT TDYFSKLSVR DLLGSELPEN ASGGDKPLIA DADVAAKDPR QLERLLAQAE DEDDVKAANL AMREVEIDND DFDESTEKKA ANEEEENHAE LDEYEGTAHV DEYMIRFIAN GYYY //