ID RRP5_YEAST Reviewed; 1729 AA. AC Q05022; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 20-FEB-2007, entry version 54. DE rRNA biogenesis protein RRP5 (Ribosomal RNA-processing protein 5). GN Name=RRP5; Synonyms=FMI1; OrderedLocusNames=YMR229C; GN ORFNames=YM9959.11C; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204511 / S288c / AB972; RX MEDLINE=97313268; PubMed=9169872; RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., RA Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., RA Rice P., Skelton J., Walsh S.V., Whitehead S., Barrell B.G.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome RT XIII."; RL Nature 387:90-93(1997). RN [2] RP CHARACTERIZATION. RX MEDLINE=97051828; PubMed=8896463; RA Venema J., Tollervey D.; RT "RRP5 is required for formation of both 18S and 5.8S rRNA in yeast."; RL EMBO J. 15:5701-5714(1996). RN [3] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., RA Dephoure N., O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47, AND MASS RP SPECTROMETRY. RX PubMed=15665377; DOI=10.1074/mcp.M400219-MCP200; RA Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., RA Mann M., Jensen O.N.; RT "Quantitative phosphoproteomics applied to the yeast pheromone RT signaling pathway."; RL Mol. Cell. Proteomics 4:310-327(2005). CC -!- FUNCTION: Involved in the biogenesis of rRNA. Required for the CC formation of 18S and 5.8S rRNA. CC -!- INTERACTION: CC P06781:RHO2; NbExp=1; IntAct=EBI-16011, EBI-15133; CC -!- SUBCELLULAR LOCATION: Nucleus; nucleolus. CC -!- MISCELLANEOUS: Present with 8860 molecules/cell. CC -!- SIMILARITY: Contains 4 HAT repeats. CC -!- SIMILARITY: Contains 11 S1 motif domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z49939; CAA90200.1; -; Genomic_DNA. DR PIR; S57596; S57596. DR HSSP; P05055; 1SRO. DR DIP; DIP:6535N; -. DR IntAct; Q05022; -. DR Ensembl; YMR229C; Saccharomyces cerevisiae. DR GenomeReviews; Z71257_GR; YMR229C. DR KEGG; sce:YMR229C; -. DR CYGD; YMR229c; -. DR SGD; S000004842; RRP5. DR BioCyc; SCER-S28-01:SCER-S28-01-004751-MONOMER; -. DR LinkHub; Q05022; -. DR GermOnline; YMR229C; Saccharomyces cerevisiae. DR GO; GO:0005732; C:small nucleolar ribonucleoprotein complex; IPI:SGD. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0042134; F:rRNA primary transcript binding; IDA:SGD. DR GO; GO:0030515; F:snoRNA binding; IPI:SGD. DR GO; GO:0006365; P:35S primary transcript processing; IPI:SGD. DR GO; GO:0030490; P:processing of 20S pre-rRNA; IPI:SGD. DR InterPro; IPR003107; HAT. DR InterPro; IPR008994; OB_fold_NA_bd. DR InterPro; IPR012340; OB_NA_bd_sub. DR InterPro; IPR008940; Prenyl_trans. DR InterPro; IPR003029; S1_RNA_bd. DR InterPro; IPR011990; TPR-like_helical. DR Gene3D; G3DSA:2.40.50.140; NA-bind_OB_sub; 10. DR Gene3D; G3DSA:1.25.40.10; TPR-like_helical; 2. DR Pfam; PF00575; S1; 3. DR SMART; SM00386; HAT; 6. DR SMART; SM00316; S1; 12. DR PROSITE; PS50126; S1; 11. KW Complete proteome; Nuclear protein; Phosphorylation; Repeat; KW rRNA processing. FT CHAIN 1 1729 rRNA biogenesis protein RRP5. FT /FTId=PRO_0000205763. FT DOMAIN 119 200 S1 motif 1. FT DOMAIN 338 410 S1 motif 2. FT DOMAIN 510 580 S1 motif 3. FT DOMAIN 607 676 S1 motif 4. FT DOMAIN 690 769 S1 motif 5. FT DOMAIN 794 863 S1 motif 6. FT DOMAIN 895 971 S1 motif 7. FT DOMAIN 1003 1083 S1 motif 8. FT DOMAIN 1088 1159 S1 motif 9. FT DOMAIN 1177 1245 S1 motif 10. FT DOMAIN 1265 1336 S1 motif 11. FT REPEAT 1455 1487 HAT 1. FT REPEAT 1561 1594 HAT 2. FT REPEAT 1632 1664 HAT 3. FT REPEAT 1666 1701 HAT 4. FT MOD_RES 47 47 Phosphothreonine. SQ SEQUENCE 1729 AA; 193134 MW; 39BF46E5587B3B0A CRC64; MVASTKRKRD EDFPLSREDS TKQPSTSSLV RNTEEVSFPR GGASALTPLE LKQVANEAAS DVLFGNESVK ASEPASRPLK KKKTTKKSTS KDSEASSANS DEARAGLIEH VNFKTLKNGS SLLGQISAIT KQDLCITFTD GISGYVNLTH ISEEFTSILE DLDEDMDSDT DAADEKKSKV EDAEYESSDD EDEKLDKSNE LPNLRRYFHI GQWLRCSVIK NTSLEPSTKK SKKKRIELTI EPSSVNIYAD EDLVKSTSIQ CAVKSIEDHG ATLDVGLPGF TGFIAKKDFG NFEKLLPGAV FLGNITKKSD RSIVVNTDFS DKKNKITQIS SIDAIIPGQI VDLLCESITK NGIAGKVFGL VSGVVNVSHL RTFSEEDLKH KFVIGSSIRC RIIACLENKS GDKVLILSNL PHILKLEDAL RSTEGLDAFP IGYTFESCSI KGRDSEYLYL ALDDDRLGKV HSSRVGEIEN SENLSSRVLG YSPVDDIYQL STDPKYLKLK YLRTNDIPIG ELLPSCEITS VSSSGIELKI FNGQFKASVP PLHISDTRLV YPERKFKIGS KVKGRVISVN SRGNVHVTLK KSLVNIEDNE LPLVSTYENA KNIKEKNEKT LATIQVFKPN GCIISFFGGL SGFLPNSEIS EVFVKRPEEH LRLGQTVIVK LLDVDADRRR IIATCKVSNE QAAQQKDTIE NIVPGRTIIT VHVIEKTKDS VIVEIPDVGL RGVIYVGHLS DSRIEQNRAQ LKKLRIGTEL TGLVIDKDTR TRVFNMSLKS SLIKDAKKET LPLTYDDVKD LNKDVPMHAY IKSISDKGLF VAFNGKFIGL VLPSYAVDSR DIDISKAFYI NQSVTVYLLR TDDKNQKFLL SLKAPKVKEE KKKVESNIED PVDSSIKSWD DLSIGSIVKA KIKSVKKNQL NVILAANLHG RVDIAEVFDT YEEITDKKQP LSNYKKDDVI KVKIIGNHDV KSHKFLPITH KISKASVLEL SMKPSELKSK EVHTKSLEEI NIGQELTGFV NNSSGNHLWL TISPVLKARI SLLDLADNDS NFSENIESVF PLGSALQVKV ASIDREHGFV NAIGKSHVDI NMSTIKVGDE LPGRVLKIAE KYVLLDLGNK VTGISFITDA LNDFSLTLKE AFEDKINNVI PTTVLSVDEQ NKKIELSLRP ATAKTRSIKS HEDLKQGEIV DGIVKNVNDK GIFVYLSRKV EAFVPVSKLS DSYLKEWKKF YKPMQYVLGK VVTCDEDSRI SLTLRESEIN GDLKVLKTYS DIKAGDVFEG TIKSVTDFGV FVKLDNTVNV TGLAHITEIA DKKPEDLSAL FGVGDRVKAI VLKTNPEKKQ ISLSLKASHF SKEAELASTT TTTTTVDQLE KEDEDEVMAD AGFNDSDSES DIGDQNTEVA DRKPETSSDG LSLSAGFDWT ASILDQAQEE EESDQDQEDF TENKKHKHKR RKENVVQDKT IDINTRAPES VADFERLLIG NPNSSVVWMN YMAFQLQLSE IEKARELAER ALKTINFREE AEKLNIWIAM LNLENTFGTE ETLEEVFSRA CQYMDSYTIH TKLLGIYEIS EKFDKAAELF KATAKKFGGE KVSIWVSWGD FLISHNEEQE ARTILGNALK ALPKRNHIEV VRKFAQLEFA KGDPERGRSL FEGLVADAPK RIDLWNVYVD QEVKAKDKKK VEDLFERIIT KKITRKQAKF FFNKWLQFEE SEGDEKTIEY VKAKATEYVA SHESQKADE //