ID YM71_YEAST Reviewed; 267 AA. AC Q05016; D6W051; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 03-APR-2013, entry version 100. DE RecName: Full=Uncharacterized oxidoreductase YMR226C; DE EC=1.-.-.-; GN OrderedLocusNames=YMR226C; ORFNames=YM9959.08C; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; OC Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204511 / S288c / AB972; RX PubMed=9169872; RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., RA Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., RA Rice P., Skelton J., Walsh S.V., Whitehead S., Barrell B.G.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome RT XIII."; RL Nature 387:90-93(1997). RN [2] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RG Saccharomyces Genome Database; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [3] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., RA Dephoure N., O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). CC -!- MISCELLANEOUS: Present with 3210 molecules/cell in log phase SD CC medium. CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases CC (SDR) family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z49939; CAA90197.1; -; Genomic_DNA. DR EMBL; BK006946; DAA10125.1; -; Genomic_DNA. DR PIR; S57593; S57593. DR RefSeq; NP_013953.1; NM_001182733.1. DR PDB; 3RKU; X-ray; 2.60 A; A/B/C/D=1-267. DR PDBsum; 3RKU; -. DR ProteinModelPortal; Q05016; -. DR SMR; Q05016; 1-267. DR DIP; DIP-1671N; -. DR IntAct; Q05016; 13. DR MINT; MINT-409559; -. DR STRING; 4932.YMR226C; -. DR PaxDb; Q05016; -. DR PeptideAtlas; Q05016; -. DR EnsemblFungi; YMR226C; YMR226C; YMR226C. DR GeneID; 855266; -. DR KEGG; sce:YMR226C; -. DR CYGD; YMR226c; -. DR SGD; S000004839; YMR226C. DR eggNOG; COG4221; -. DR GeneTree; ENSGT00700000104443; -. DR KO; K16066; -. DR OMA; DWENMID; -. DR OrthoDB; EOG40S3R2; -. DR NextBio; 978870; -. DR Genevestigator; Q05016; -. DR GermOnline; YMR226C; Saccharomyces cerevisiae. DR GO; GO:0005737; C:cytoplasm; IDA:SGD. DR GO; GO:0016021; C:integral to membrane; ISM:SGD. DR GO; GO:0005634; C:nucleus; IDA:SGD. DR GO; GO:0004090; F:carbonyl reductase (NADPH) activity; IDA:SGD. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IDA:SGD. DR Gene3D; 3.40.50.720; -; 1. DR InterPro; IPR002198; DH_sc/Rdtase_SDR. DR InterPro; IPR002347; Glc/ribitol_DH. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR020904; Sc_DH/Rdtase_CS. DR Pfam; PF00106; adh_short; 1. DR PIRSF; PIRSF000126; 11-beta-HSD1; 1. DR PRINTS; PR00081; GDHRDH. DR PRINTS; PR00080; SDRFAMILY. DR PROSITE; PS00061; ADH_SHORT; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Oxidoreductase; Reference proteome. FT CHAIN 1 267 Uncharacterized oxidoreductase YMR226C. FT /FTId=PRO_0000054873. FT NP_BIND 17 44 NAD or NADP (By similarity). FT ACT_SITE 168 168 Proton acceptor (By similarity). FT BINDING 155 155 Substrate (By similarity). FT HELIX 5 11 FT STRAND 15 20 FT HELIX 24 36 FT TURN 37 39 FT STRAND 41 48 FT HELIX 50 63 FT STRAND 68 73 FT HELIX 79 81 FT HELIX 82 87 FT HELIX 91 93 FT STRAND 98 101 FT HELIX 117 127 FT HELIX 129 145 FT STRAND 149 153 FT HELIX 156 158 FT HELIX 166 185 FT TURN 186 188 FT STRAND 192 199 FT STRAND 201 204 FT HELIX 205 209 FT TURN 210 212 FT HELIX 214 221 FT HELIX 229 240 FT STRAND 246 255 FT STRAND 258 260 SQ SEQUENCE 267 AA; 29158 MW; 77FCD713F724A9D7 CRC64; MSQGRKAAER LAKKTVLITG ASAGIGKATA LEYLEASNGD MKLILAARRL EKLEELKKTI DQEFPNAKVH VAQLDITQAE KIKPFIENLP QEFKDIDILV NNAGKALGSD RVGQIATEDI QDVFDTNVTA LINITQAVLP IFQAKNSGDI VNLGSIAGRD AYPTGSIYCA SKFAVGAFTD SLRKELINTK IRVILIAPGL VETEFSLVRY RGNEEQAKNV YKDTTPLMAD DVADLIVYAT SRKQNTVIAD TLIFPTNQAS PHHIFRG //