ID Q04JX6_STRP2 Unreviewed; 427 AA. AC Q04JX6; DT 14-NOV-2006, integrated into UniProtKB/TrEMBL. DT 14-NOV-2006, sequence version 1. DT 23-OCT-2007, entry version 10. DE 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19). GN Name=aroA; OrderedLocusNames=SPD_1205; OS Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466). OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=373153; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17041037; DOI=10.1128/JB.01148-06; RA Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., RA Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.; RT "Genome sequence of Avery's virulent serotype 2 strain D39 of RT Streptococcus pneumoniae and comparison with that of unencapsulated RT laboratory strain R6."; RL J. Bacteriol. 189:38-51(2007). CC -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + 3-phosphoshikimate = CC phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. CC -!- SIMILARITY: Belongs to the EPSP synthase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000410; ABJ54185.1; -; Genomic_DNA. DR RefSeq; YP_816672.1; -. DR GeneID; 4441387; -. DR GenomeReviews; CP000410_GR; SPD_1205. DR GO; GO:0003866; F:3-phosphoshikimate 1-carboxyvinyltransferas...; IEA:InterPro. DR GO; GO:0016089; P:aromatic amino acid family biosynthetic pro...; IEA:InterPro. DR InterPro; IPR001986; EPSP_synthase. DR InterPro; IPR006264; EPSP_synthase_subgroup. DR Gene3D; G3DSA:3.65.10.10; EPSP_synthase; 2. DR Pfam; PF00275; EPSP_synthase; 1. DR ProDom; PD001867; EPSP_synth; 1. DR TIGRFAMs; TIGR01356; aroA; 1. DR PROSITE; PS00104; EPSP_SYNTHASE_1; 1. DR PROSITE; PS00885; EPSP_SYNTHASE_2; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; KW Complete proteome; Cytoplasm; Transferase. SQ SEQUENCE 427 AA; 45720 MW; D48A60F444E45818 CRC64; MKLKTNIRHL HGSIRVPGDK SISHRSIIFG SLAEGETKVY DILRGEDVLS TMQVFRDLGV EIEDKDGVIT IQGVGMAGLK APQNALNMGN SGTSIRLISG VLAGADFEVE MFGDDSLSKR PMDRVTLPLK KMGVSISGQT ERDLPPLRLK GTKNLRPIHY ELPIASAQVK SALMFAALQA KGESVIIEKE CTRNHTEDML KQFGGHLSVD GKKITVQGPQ KLTGQKVVVP GDISSAAFWL VAGLINPNSH LVLQNVGINE TRTGIIDVIR AMGGKLEVTE IDPVAKSSTL TVESSDLKGT EIGGALIPRL IDELPIIALL ATQAQGVTVI KDAEELKVKE TDRIQVVADA LNSMGADITP TADGMIIKGK SALHGARVNT FGDHRIGMMT AIAALLVADG EVELDRAEAI NTSYPSFFDD LESLIHG //