ID BSH_DROME Reviewed; 429 AA. AC Q04787; Q4V6V3; Q7KT32; Q9VIS2; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 13-JUN-2006, sequence version 5. DT 15-JUN-2010, entry version 89. DE RecName: Full=Brain-specific homeobox protein; GN Name=bsh; ORFNames=CG10604; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). RC STRAIN=Berkeley; RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-429 (ISOFORM B), FUNCTION, RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE. RC STRAIN=Oregon-R; RX MEDLINE=93321621; PubMed=8101170; RA Jones B., McGinnis W.; RT "A new Drosophila homeobox gene, bsh, is expressed in a subset of RT brain cells during embryogenesis."; RL Development 117:793-806(1993). CC -!- FUNCTION: DNA binding protein that function as transcriptional CC activator (By similarity). May play a role in the determination CC and function of cell types in the brain. CC -!- INTERACTION: CC Q9VD99:C15; NbExp=1; IntAct=EBI-96948, EBI-133988; CC Q9VEI8:Hmx; NbExp=1; IntAct=EBI-96948, EBI-161277; CC P06002:ninaE; NbExp=1; IntAct=EBI-96948, EBI-100064; CC Q9W3W8:RpL17; NbExp=1; IntAct=EBI-96948, EBI-128035; CC Q9W424:Spx; NbExp=1; IntAct=EBI-96948, EBI-174910; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=B; CC IsoId=Q04787-1; Sequence=Displayed; CC Name=A; CC IsoId=Q04787-2; Sequence=VSP_011542; CC Note=No experimental confirmation available; CC -!- TISSUE SPECIFICITY: Embryonic brain; accumulates in approximately CC 30 cells in each brain hemisphere. One of these cells is closely CC associated with the terminus of the larval visual nerve (Bolwig's CC nerve). CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis with very low CC levels found in the larva and adult. CC -!- SIMILARITY: Belongs to the distal-less homeobox family. CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain. CC -!- SEQUENCE CAUTION: CC Sequence=AAB59219.1; Type=Frameshift; Positions=119, 138, 333, 341; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF53843.2; -; Genomic_DNA. DR EMBL; AE014134; AAS64721.2; -; Genomic_DNA. DR EMBL; BT022203; AAY51597.1; -; mRNA. DR EMBL; L06475; AAB59219.1; ALT_FRAME; Genomic_DNA. DR RefSeq; NP_477350.1; -. DR RefSeq; NP_995728.2; -. DR UniGene; Dm.25407; -. DR SMR; Q04787; 275-331. DR DIP; DIP-17210N; -. DR IntAct; Q04787; 23. DR MINT; MINT-285443; -. DR STRING; Q04787; -. DR EnsemblMetazoa; FBtr0089319; FBpp0088361; FBgn0000529. DR EnsemblMetazoa; FBtr0089320; FBpp0088920; FBgn0000529. DR GeneID; 35266; -. DR KEGG; dme:Dmel_CG10604; -. DR CTD; 35266; -. DR FlyBase; FBgn0000529; bsh. DR eggNOG; inNOG10066; -. DR InParanoid; Q04787; -. DR OMA; ANEPVDF; -. DR OrthoDB; EOG9WWRQV; -. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-009569-MONOMER; -. DR NextBio; 792701; -. DR Bgee; Q04787; -. DR GermOnline; CG10604; Drosophila melanogaster. DR GO; GO:0005634; C:nucleus; NAS:UniProtKB. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0003700; F:transcription factor activity; NAS:UniProtKB. DR GO; GO:0007420; P:brain development; IMP:UniProtKB. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW. DR InterPro; IPR001356; Homeobox. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR020479; Homeobox_region. DR InterPro; IPR009057; Homeodomain-like. DR InterPro; IPR012287; Homeodomain-rel. DR InterPro; IPR000047; HTH_lambrepressr. DR Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1. DR Pfam; PF00046; Homeobox; 1. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain_like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 1: Evidence at protein level; KW Activator; Alternative splicing; Complete proteome; KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription; KW Transcription regulation. FT CHAIN 1 429 Brain-specific homeobox protein. FT /FTId=PRO_0000048841. FT DNA_BIND 274 333 Homeobox. FT COMPBIAS 177 191 Pro-rich. FT VAR_SEQ 1 142 Missing (in isoform A). FT /FTId=VSP_011542. FT CONFLICT 301 301 T -> P (in Ref. 4; AAB59219). SQ SEQUENCE 429 AA; 45714 MW; 32CF539EE0DEE572 CRC64; MAMLNEASLS PADAHAHANA TTPTHSKAAA MASATTMLTT KTPFSIEHIL FQNLNSASNN NNSSDTNGIA ANTNNYAPKS SRNAVKSARS AFAHDNNPHK HPSQHSHPPQ SHPPASASAS ATATARSNQA ASGYAGEDYG KSMHSTPRSN HHSRHGTSHY NGDQISQQLG SGAAQHPPVP TTQPQPPPPP PLNGGSGASN GVLYPNAPYT DHGFLQMTLG YLSPSSGTYK SVDPYFLSQA SLFGGAPFFG APGCVPELAL GLGMGVNALR HCRRRKARTV FSDPQLSGLE KRFEGQRYLS TPERVELATA LGLSETQVKT WFQNRRMKHK KQLRRRDNAN EPVDFSRSEP GKQPGEATSS SGDSKHGKLN PGSVGGTPTQ PTSEQQLQMC LMQQGYSTDD YSDLEADSGD EDNSSDVDIV GDAKLYQLT //