ID BSH_DROME STANDARD; PRT; 427 AA. AC Q04787; Q7KT32; Q9VIS2; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 31-AUG-2004, sequence version 4. DT 30-MAY-2006, entry version 53. DE Brain-specific homeobox protein. GN Name=bsh; ORFNames=CG10604; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-427 (ISOFORM B), FUNCTION, RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE. RC STRAIN=Oregon-R; RX MEDLINE=93321621; PubMed=8101170; RA Jones B., McGinnis W.; RT "A new Drosophila homeobox gene, bsh, is expressed in a subset of RT brain cells during embryogenesis."; RL Development 117:793-806(1993). CC -!- FUNCTION: May play a role in the determination and function of CC cell types in the brain. CC -!- INTERACTION: CC Q9VD99:C15; NbExp=1; IntAct=EBI-96948, EBI-133988; CC Q9VEI8:Hmx; NbExp=1; IntAct=EBI-96948, EBI-161277; CC P06002:ninaE; NbExp=1; IntAct=EBI-96948, EBI-100064; CC Q9W3W8:RpL17; NbExp=1; IntAct=EBI-96948, EBI-128035; CC Q9W424:Spx; NbExp=1; IntAct=EBI-96948, EBI-174910; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=B; CC IsoId=Q04787-1; Sequence=Displayed; CC Name=A; CC IsoId=Q04787-2; Sequence=VSP_011542; CC Note=No experimental confirmation available; CC -!- TISSUE SPECIFICITY: Embryonic brain; accumulates in approximately CC 30 cells in each brain hemisphere. One of these cells is closely CC associated with the terminus of the larval visual nerve (Bolwig's CC nerve). CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis with very low CC levels found in the larva and adult. CC -!- SIMILARITY: Belongs to the distal-less homeobox family. CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain. CC -!- CAUTION: Ref.3 sequence differs from that shown due to frameshifts CC in positions 117, 136, 331 and 339. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE003664; AAF53843.2; -; Genomic_DNA. DR EMBL; AE003664; AAS64721.1; -; Genomic_DNA. DR EMBL; L06475; AAB59219.1; ALT_FRAME; Genomic_DNA. DR UniGene; Dm.25407; -. DR HSSP; P14653; 1B72. DR IntAct; Q04787; -. DR Ensembl; CG10604; Drosophila melanogaster. DR FlyBase; FBgn0000529; bsh. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-009569-MONOMER; -. DR GO; GO:0005634; C:nucleus; NAS. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0003700; F:transcription factor activity; NAS. DR GO; GO:0007420; P:brain development; IMP. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; NAS. DR InterPro; IPR001356; Homeobox. DR InterPro; IPR012287; Homeodomain-rel. DR InterPro; IPR009057; Homeodomain_like. DR InterPro; IPR000047; HTH_lambrepressr. DR Pfam; PF00046; Homeobox; 1. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR ProDom; PD000010; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW Alternative splicing; Complete proteome; Developmental protein; KW DNA-binding; Homeobox; Nuclear protein. FT CHAIN 1 427 Brain-specific homeobox protein. FT /FTId=PRO_0000048841. FT DNA_BIND 270 330 Homeobox. FT COMPBIAS 175 189 Pro-rich. FT VAR_SEQ 1 140 Missing (in isoform A). FT /FTId=VSP_011542. FT CONFLICT 299 299 T -> P (in Ref. 3). SQ SEQUENCE 427 AA; 45512 MW; DF8FC295CE45AEC8 CRC64; MLNEASLSPA DAHAHANATT PTHSKAAAMA SATTMLTTKT PFSIEHILFQ NLNSASNNNN SSDTNGIAAN TNNYAPKSSR NAVKSARSAF AHDNNPHKHP SQHSHPPQSH PPASASASAT ATARSNQAAS GYAGEDYGKS MHSTPRSNHH SRHGTSHYNG DQISQQLGSG AAQHPPVPTT QPQPPPPPPL NGGSGASNGV LYPNAPYTDH GFLQMTLGYL SPSSGTYKSV DPYFLSQASL FGGAPFFGAP GCVPELALGL GMGVNALRHC RRRKARTVFS DPQLSGLEKR FEGQRYLSTP ERVELATALG LSETQVKTWF QNRRMKHKKQ LRRRDNANEP VDFSRSEPGK QPGEATSSSG DSKHGKLNPG SVGGTPTQPT SEQQLQMCLM QQGYSTDDYS DLEADSGDED NSSDVDIVGD AKLYQLT //