ID BSH_DROME Reviewed; 429 AA. AC Q04787; Q4V6V3; Q7KT32; Q9VIS2; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 13-JUN-2006, sequence version 5. DT 08-NOV-2023, entry version 186. DE RecName: Full=Brain-specific homeobox protein; GN Name=bsh; ORFNames=CG10604; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., RA Park S., Wan K.H., Yu C., Celniker S.E.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-429, FUNCTION, TISSUE SPECIFICITY, RP AND DEVELOPMENTAL STAGE. RC STRAIN=Oregon-R; RX PubMed=8101170; DOI=10.1242/dev.117.2.793; RA Jones B., McGinnis W.; RT "A new Drosophila homeobox gene, bsh, is expressed in a subset of brain RT cells during embryogenesis."; RL Development 117:793-806(1993). CC -!- FUNCTION: DNA binding protein that function as transcriptional CC activator (By similarity). May play a role in the determination and CC function of cell types in the brain. {ECO:0000250, CC ECO:0000269|PubMed:8101170}. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- TISSUE SPECIFICITY: Embryonic brain; accumulates in approximately 30 CC cells in each brain hemisphere. One of these cells is closely CC associated with the terminus of the larval visual nerve (Bolwig's CC nerve). {ECO:0000269|PubMed:8101170}. CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis with very low CC levels found in the larva and adult. {ECO:0000269|PubMed:8101170}. CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAB59219.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF53843.3; -; Genomic_DNA. DR EMBL; AE014134; AAS64721.2; -; Genomic_DNA. DR EMBL; BT022203; AAY51597.1; -; mRNA. DR EMBL; L06475; AAB59219.1; ALT_FRAME; Genomic_DNA. DR RefSeq; NP_477350.2; NM_058002.3. DR RefSeq; NP_995728.2; NM_206006.2. DR AlphaFoldDB; Q04787; -. DR SMR; Q04787; -. DR BioGRID; 61242; 29. DR DIP; DIP-17210N; -. DR IntAct; Q04787; 7. DR STRING; 7227.FBpp0088920; -. DR PaxDb; 7227-FBpp0088920; -. DR DNASU; 35266; -. DR EnsemblMetazoa; FBtr0089320; FBpp0088920; FBgn0000529. DR EnsemblMetazoa; FBtr0343855; FBpp0310398; FBgn0000529. DR GeneID; 35266; -. DR KEGG; dme:Dmel_CG10604; -. DR AGR; FB:FBgn0000529; -. DR CTD; 35266; -. DR FlyBase; FBgn0000529; bsh. DR VEuPathDB; VectorBase:FBgn0000529; -. DR eggNOG; KOG0491; Eukaryota. DR GeneTree; ENSGT00940000165097; -. DR HOGENOM; CLU_049799_0_0_1; -. DR InParanoid; Q04787; -. DR OMA; CFLQHGY; -. DR OrthoDB; 4204245at2759; -. DR PhylomeDB; Q04787; -. DR Reactome; R-DME-8853884; Transcriptional Regulation by VENTX. DR SignaLink; Q04787; -. DR BioGRID-ORCS; 35266; 0 hits in 1 CRISPR screen. DR GenomeRNAi; 35266; -. DR PRO; PR:Q04787; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0000529; Expressed in embryonic brain and 2 other tissues. DR Genevisible; Q04787; DM. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0007420; P:brain development; IMP:UniProtKB. DR GO; GO:0048663; P:neuron fate commitment; IMP:FlyBase. DR GO; GO:0006355; P:regulation of DNA-templated transcription; NAS:UniProtKB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR020479; Homeobox_metazoa. DR InterPro; IPR000047; HTH_motif. DR PANTHER; PTHR24333; HOMEO BOX HB9 LIKE A-RELATED; 1. DR PANTHER; PTHR24333:SF8; HOMEOBOX PROTEIN CEH-62; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus; KW Reference proteome; Transcription; Transcription regulation. FT CHAIN 1..429 FT /note="Brain-specific homeobox protein" FT /id="PRO_0000048841" FT DNA_BIND 274..333 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 1..27 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 59..204 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 326..429 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 59..87 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 110..131 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 159..178 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 179..194 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 352..401 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CONFLICT 301 FT /note="T -> P (in Ref. 4; AAB59219)" FT /evidence="ECO:0000305" SQ SEQUENCE 429 AA; 45714 MW; 32CF539EE0DEE572 CRC64; MAMLNEASLS PADAHAHANA TTPTHSKAAA MASATTMLTT KTPFSIEHIL FQNLNSASNN NNSSDTNGIA ANTNNYAPKS SRNAVKSARS AFAHDNNPHK HPSQHSHPPQ SHPPASASAS ATATARSNQA ASGYAGEDYG KSMHSTPRSN HHSRHGTSHY NGDQISQQLG SGAAQHPPVP TTQPQPPPPP PLNGGSGASN GVLYPNAPYT DHGFLQMTLG YLSPSSGTYK SVDPYFLSQA SLFGGAPFFG APGCVPELAL GLGMGVNALR HCRRRKARTV FSDPQLSGLE KRFEGQRYLS TPERVELATA LGLSETQVKT WFQNRRMKHK KQLRRRDNAN EPVDFSRSEP GKQPGEATSS SGDSKHGKLN PGSVGGTPTQ PTSEQQLQMC LMQQGYSTDD YSDLEADSGD EDNSSDVDIV GDAKLYQLT //