ID BSH_DROME Reviewed; 429 AA. AC Q04787; Q4V6V3; Q7KT32; Q9VIS2; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 13-JUN-2006, sequence version 5. DT 11-DEC-2019, entry version 168. DE RecName: Full=Brain-specific homeobox protein; GN Name=bsh; ORFNames=CG10604; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., RA Park S., Wan K.H., Yu C., Celniker S.E.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-429, FUNCTION, TISSUE SPECIFICITY, RP AND DEVELOPMENTAL STAGE. RC STRAIN=Oregon-R; RX PubMed=8101170; RA Jones B., McGinnis W.; RT "A new Drosophila homeobox gene, bsh, is expressed in a subset of brain RT cells during embryogenesis."; RL Development 117:793-806(1993). CC -!- FUNCTION: DNA binding protein that function as transcriptional CC activator (By similarity). May play a role in the determination and CC function of cell types in the brain. {ECO:0000250, CC ECO:0000269|PubMed:8101170}. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- TISSUE SPECIFICITY: Embryonic brain; accumulates in approximately 30 CC cells in each brain hemisphere. One of these cells is closely CC associated with the terminus of the larval visual nerve (Bolwig's CC nerve). {ECO:0000269|PubMed:8101170}. CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis with very low CC levels found in the larva and adult. {ECO:0000269|PubMed:8101170}. CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAB59219.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF53843.3; -; Genomic_DNA. DR EMBL; AE014134; AAS64721.2; -; Genomic_DNA. DR EMBL; BT022203; AAY51597.1; -; mRNA. DR EMBL; L06475; AAB59219.1; ALT_FRAME; Genomic_DNA. DR RefSeq; NP_477350.2; NM_058002.3. DR RefSeq; NP_995728.2; NM_206006.2. DR SMR; Q04787; -. DR BioGrid; 61242; 27. DR DIP; DIP-17210N; -. DR IntAct; Q04787; 4. DR STRING; 7227.FBpp0088920; -. DR PaxDb; Q04787; -. DR PRIDE; Q04787; -. DR EnsemblMetazoa; FBtr0089320; FBpp0088920; FBgn0000529. DR EnsemblMetazoa; FBtr0343855; FBpp0310398; FBgn0000529. DR GeneID; 35266; -. DR KEGG; dme:Dmel_CG10604; -. DR CTD; 35266; -. DR FlyBase; FBgn0000529; bsh. DR eggNOG; KOG0491; Eukaryota. DR eggNOG; ENOG4111UAT; LUCA. DR GeneTree; ENSGT00940000165097; -. DR InParanoid; Q04787; -. DR OMA; ANEPVDF; -. DR OrthoDB; 858478at2759; -. DR PhylomeDB; Q04787; -. DR GenomeRNAi; 35266; -. DR PRO; PR:Q04787; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0000529; Expressed in 6 organ(s), highest expression level in central brain primordium (Drosophila). DR Genevisible; Q04787; DM. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0007420; P:brain development; IMP:UniProtKB. DR GO; GO:0048663; P:neuron fate commitment; IMP:FlyBase. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR020479; Homeobox_metazoa. DR InterPro; IPR000047; HTH_motif. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus; KW Reference proteome; Transcription; Transcription regulation. FT CHAIN 1..429 FT /note="Brain-specific homeobox protein" FT /id="PRO_0000048841" FT DNA_BIND 274..333 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT COMPBIAS 177..191 FT /note="Pro-rich" FT CONFLICT 301 FT /note="T -> P (in Ref. 4; AAB59219)" FT /evidence="ECO:0000305" SQ SEQUENCE 429 AA; 45714 MW; 32CF539EE0DEE572 CRC64; MAMLNEASLS PADAHAHANA TTPTHSKAAA MASATTMLTT KTPFSIEHIL FQNLNSASNN NNSSDTNGIA ANTNNYAPKS SRNAVKSARS AFAHDNNPHK HPSQHSHPPQ SHPPASASAS ATATARSNQA ASGYAGEDYG KSMHSTPRSN HHSRHGTSHY NGDQISQQLG SGAAQHPPVP TTQPQPPPPP PLNGGSGASN GVLYPNAPYT DHGFLQMTLG YLSPSSGTYK SVDPYFLSQA SLFGGAPFFG APGCVPELAL GLGMGVNALR HCRRRKARTV FSDPQLSGLE KRFEGQRYLS TPERVELATA LGLSETQVKT WFQNRRMKHK KQLRRRDNAN EPVDFSRSEP GKQPGEATSS SGDSKHGKLN PGSVGGTPTQ PTSEQQLQMC LMQQGYSTDD YSDLEADSGD EDNSSDVDIV GDAKLYQLT //