ID Q04787 PRELIMINARY; PRT; 226 AA. AC Q04787; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 01-JUN-2000 (TrEMBLrel. 14, Last annotation update) DE BRAIN-SPECIFIC HOMEOBOX PROTEIN. GN BSH. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=OREGON-R; RX MEDLINE; 93321621. RA Jones B., McGinnis W.; RT "A new Drosophila homeobox gene, bsh, is expressed in a subset of RT brain cells during embryogenesis."; RL Development 117:793-806(1993). CC -!- FUNCTION: MAY PLAY A ROLE IN THE DETERMINATION AND FUNCTION OF CC CELL TYPES IN THE BRAIN. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- TISSUE SPECIFICITY: BRAIN. THE PROTEIN ACCUMULATES IN CC APPROXIMATELY 30 CELLS IN EACH BRAIN HEMISPHERE. ONE OF THESE CC CELLS IS CLOSELY ASSOCIATED WITH THE TERMINUS OF THE LARVAL VISUAL CC NERVE (BOLWIG'S NERVE). CC -!- DEVELOPMENTAL STAGE: EXPRESSED DURING EMBRYOGENESIS WITH VERY LOW CC LEVELS FOUND IN THE LARVA AND ADULT. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L06475; AAB59219.1; -. DR HSSP; P14653; 1B72. DR FLYBASE; FBgn0000529; bsh. DR INTERPRO; IPR000047; -. DR INTERPRO; IPR001356; -. DR PFAM; PF00046; homeobox; 1. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW Homeobox; DNA-binding; Developmental protein; Nuclear protein. FT DOMAIN 35 49 PRO-RICH. FT DNA_BIND 131 191 HOMEOBOX. FT VARIANT 217 217 P -> H. SQ SEQUENCE 226 AA; 24198 MW; F56C15AB77EA6E4F CRC64; MHSTPRSNHH SRHGTSHYNG DQISQQLGSG AAQHPPVPTT QPQPPPPPPL NGGSGASNGV LYPNAPYTDH GFLQMTLGYL SPSSGTYKSV DPYFLSQASL FGGAPFFGAP GCVPELALGL GMGVNALRHC RRRKARTVFS DPQLSGLEKR FEGQRYLSPP ERVELATALG LSETQVKTWF QNRRMKHKKQ LAGATMPMSP STSHAANRAS SRARPPPPPG TPSTAN //