ID GLK1_DROME STANDARD; PRT; 991 AA. AC Q03445; DT 15-JUL-1998 (REL. 36, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE GLUTAMATE RECEPTOR I PRECURSOR (DGLUR-I) (KAINATE-SELECTIVE DE GLUTAMATE RECEPTOR). GN GLU-RI. OS DROSOPHILA MELANOGASTER (FRUIT FLY). OC EUKARYOTA; METAZOA; ARTHROPODA; INSECTA; DIPTERA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 93066263. RA ULTSCH A., SCHUSTER C.M., LAUBE B., SCHLOSS P., SCHMITT B., BETZ H.; RL PROC. NATL. ACAD. SCI. U.S.A. 89:10484-10488(1992). CC -!- FUNCTION: L-GLUTAMATE ACTS AS AN EXCITATORY NEUROTRANSMITTER AT CC MANY SYNAPSES IN THE CENTRAL NERVOUS SYSTEM. THE POSTSYNAPTIC CC ACTIONS OF GLU ARE MEDIATED BY A VARIETY OF RECEPTORS THAT ARE CC NAMED ACCORDING TO THEIR SELECTIVE AGONISTS (BY SIMILARITY). CC -!- SUBUNIT: FORMS HOMOOLIGOMERIC CHANNELS WHICH ARE ACTIVATED BY CC KAINATE. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- DEVELOPMENTAL STAGE: NO EXPRESSION IS SEEN IN EARLY EMBRYOGENESIS, CC WHEREAS HIGH EXPRESSION OCCURS IN LATE EMBRYOS. DURING LARVAL CC DEVELOPMENT, EXPRESSION DECREASES TO UNDETECTABLE LEVELS IN LATE CC LARVAE, RESUMES AT THE EARLY PUPAL STAGE AND GRADUALLY INCREASES CC IN LATE PUPAE AND EARLY ADULT FLIES. HIGH LEVELS OF EXPRESSION CC COINCIDE WITH MAJOR STAGES OF NEUROGENESIS. CC -!- TISSUE SPECIFICITY: CENTRAL NERVOUS SYSTEM. CC -!- SIMILARITY: BELONGS TO THE LIGAND-GATED IONIC CHANNELS FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M97192; G157511; -. DR FLYBASE; FBgn0004619; Glu-RI. KW RECEPTOR; POSTSYNAPTIC MEMBRANE; IONIC CHANNEL; TRANSMEMBRANE; KW SIGNAL; GLYCOPROTEIN. FT SIGNAL 1 27 POTENTIAL. FT CHAIN 28 991 GLUTAMATE RECEPTOR I. FT DOMAIN 28 611 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 612 632 POTENTIAL. FT TRANSMEM 711 731 POTENTIAL. FT TRANSMEM 896 916 POTENTIAL. FT DOMAIN 28 32 POLY-GLN. FT DOMAIN 367 371 POLY-SER. FT CARBOHYD 67 67 POTENTIAL. FT CARBOHYD 195 195 POTENTIAL. FT CARBOHYD 208 208 POTENTIAL. FT CARBOHYD 281 281 POTENTIAL. FT CARBOHYD 376 376 POTENTIAL. FT CARBOHYD 385 385 POTENTIAL. FT CARBOHYD 426 426 POTENTIAL. FT CARBOHYD 437 437 POTENTIAL. FT CARBOHYD 477 477 POTENTIAL. SQ SEQUENCE 991 AA; 111655 MW; 9F113418 CRC32; MHSRLKFLAY LHFICASSIF WPEFSSAQQQ QQTVSLTEKI PLGAIFEQGT DDVQSAFKYA LLNHNLNVSS RRFELQAYVD VINTADAFKL SRLICNQFSR GVYSMLGAVS PDSFDTLHSY SNTFQMPFVT PWFPEKVLAP SSGLLDFAIS MRPDYHQAII DTIQYYGWQS IIYLYDSHDG LLRLQQIYQE LKPGNETFRV QMVKRIANVT MAIEFLHTLE DLGRFSKKRI VLDCPAEMAK EIIVQHVRDI KLGRRTYHYL LSGLVMDNHW PSDVVEFGAI NITGFRIVDS NRRAVRDFHD NRKRLEPSAK AKARTQGGPN SLPPISAQAA LMYDAVFVLV EAFNRILRKK PDQFRSNHLQ RRSHGGSSSS SATGTNESSA LLDCNTSKGW VTPWEQGEKI SRVLRKVEID GLSGEIRFDE DGRRINYTLH VVEMSVNSTL QQVAEWRDDA GLLPLHSHNY ASSSRSASAS TGDYDRNHTY IVSSLLEEPY LSLKQYTYGE SLVGNDRFEG YCKDLADMLA AQLGIKYEIR LVQDGNYGAE NQYAPGGWDG MVGELIRKEA DIAISAMTIT AERERVIDFS KPFMTLGISI MIKKPVKQTP GVFSFLNPLS QEIWISVILS YVGVSFVLYF VTRFPPYEWR IVRRPQADST AQQPPGIIGG ATLSEPQAHV PPVPPNEFTM LNSFWYSLAA FMQQGCDITP PSIAGRIAAA VWWFFTIILI SSYTANLAAF LTVERMVAPI KTPEDLAMQT DVNYGTLLHG STWEFFRRSQ IGLHNKMWEY MNANQHHSVH TYDEGIRRVR QSKGKYALLV ESPKNEYVNA RPPCDTMKVG RNIDTKGFGV ATPIGSPLRK RLNEAVLTLK ENGELLRIRN KWWFDKTECN LDQETSTPNE LSLSNVAGIY YILIGGLLLA VIVAIVEFFC RNKTPQLKSP GSNGSAGGVP GMLGSSTYQR DSLSDAIMHS QAKLAMQASS EYDERLVGVE LASNVRYQYS M //