ID GLK1_DROME STANDARD; PRT; 991 AA. AC Q03445; Q86PC2; Q9VRX9; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 21-JUN-2005, sequence version 2. DT 19-SEP-2006, entry version 56. DE Glutamate receptor 1 precursor (Glutamate receptor I) (dGLUR-I) DE (Kainate-selective glutamate receptor). GN Name=Glu-RI; ORFNames=CG8442; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORM 1). RX MEDLINE=93066263; PubMed=1359540; RA Ultsch A., Schuster C.M., Laube B., Schloss P., Schmitt B., Betz H.; RT "Glutamate receptors of Drosophila melanogaster: cloning of a kainate- RT selective subunit expressed in the central nervous system."; RL Proc. Natl. Acad. Sci. U.S.A. 89:10484-10488(1992). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC STRAIN=Berkeley; TISSUE=Embryo; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.E.; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: L-glutamate acts as an excitatory neurotransmitter at CC many synapses in the central nervous system. The postsynaptic CC actions of Glu are mediated by a variety of receptors that are CC named according to their selective agonists (By similarity). CC -!- SUBUNIT: Forms homooligomeric channels which are activated by CC kainate. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=A; CC IsoId=Q03445-1; Sequence=Displayed; CC Name=2; CC IsoId=Q03445-2; Sequence=VSP_014219; CC Note=No experimental confirmation available; CC -!- TISSUE SPECIFICITY: Central nervous system. CC -!- DEVELOPMENTAL STAGE: No expression is seen in early embryogenesis, CC whereas high expression occurs in late embryos. During larval CC development, expression decreases to undetectable levels in late CC larvae, resumes at the early pupal stage and gradually increases CC in late pupae and early adult flies. High levels of expression CC coincide with major stages of neurogenesis. CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M97192; AAA28575.1; -; mRNA. DR EMBL; AE003562; AAF50652.2; -; Genomic_DNA. DR EMBL; BT003218; AAO24973.1; -; mRNA. DR PIR; A46421; A46421. DR UniGene; Dm.6460; -. DR HSSP; P19491; 1FTK. DR Ensembl; CG8442; Drosophila melanogaster. DR KEGG; dme:CG8442-PA; -. DR FlyBase; FBgn0004619; Glu-RI. DR GO; GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole ...; IDA. DR InterPro; IPR001828; ANF_lig_bd_rcpt. DR InterPro; IPR001311; glu_rcpt_sol_bd. DR InterPro; IPR001320; Iontro_glu_rcpt. DR InterPro; IPR001622; K+channel_pore. DR Pfam; PF01094; ANF_receptor; 1. DR Pfam; PF00060; Lig_chan; 1. DR SMART; SM00079; PBPe; 1. KW Alternative splicing; Complete proteome; Glycoprotein; Ion transport; KW Ionic channel; Membrane; Postsynaptic membrane; Receptor; Signal; KW Transmembrane; Transport. FT SIGNAL 1 27 Potential. FT CHAIN 28 991 Glutamate receptor 1. FT /FTId=PRO_0000011555. FT TOPO_DOM 28 611 Extracellular (Potential). FT TRANSMEM 612 632 Potential. FT TRANSMEM 711 731 Potential. FT TRANSMEM 896 916 Potential. FT COMPBIAS 28 32 Poly-Gln. FT COMPBIAS 367 371 Poly-Ser. FT CARBOHYD 67 67 N-linked (GlcNAc...) (Potential). FT CARBOHYD 195 195 N-linked (GlcNAc...) (Potential). FT CARBOHYD 208 208 N-linked (GlcNAc...) (Potential). FT CARBOHYD 281 281 N-linked (GlcNAc...) (Potential). FT CARBOHYD 376 376 N-linked (GlcNAc...) (Potential). FT CARBOHYD 385 385 N-linked (GlcNAc...) (Potential). FT CARBOHYD 426 426 N-linked (GlcNAc...) (Potential). FT CARBOHYD 437 437 N-linked (GlcNAc...) (Potential). FT CARBOHYD 477 477 N-linked (GlcNAc...) (Potential). FT VAR_SEQ 1 265 Missing (in isoform 2). FT /FTId=VSP_014219. FT CONFLICT 61 61 M -> L (in Ref. 1). FT CONFLICT 301 301 S -> N (in Ref. 1). FT CONFLICT 309 316 GQSQSQNA -> AKAKARTQ (in Ref. 1). FT CONFLICT 324 324 A -> P (in Ref. 1). FT CONFLICT 747 747 T -> A (in Ref. 1). FT CONFLICT 759 759 Y -> H (in Ref. 1). FT CONFLICT 916 916 M -> V (in Ref. 1). FT CONFLICT 944 944 A -> G (in Ref. 1). SQ SEQUENCE 991 AA; 111668 MW; C8917868ABA06F98 CRC64; MHSRLKFLAY LHFICASSIF WPEFSSAQQQ QQTVSLTEKI PLGAIFEQGT DDVQSAFKYA MLNHNLNVSS RRFELQAYVD VINTADAFKL SRLICNQFSR GVYSMLGAVS PDSFDTLHSY SNTFQMPFVT PWFPEKVLAP SSGLLDFAIS MRPDYHQAII DTIQYYGWQS IIYLYDSHDG LLRLQQIYQE LKPGNETFRV QMVKRIANVT MAIEFLHTLE DLGRFSKKRI VLDCPAEMAK EIIVQHVRDI KLGRRTYHYL LSGLVMDNHW PSDVVEFGAI NITGFRIVDS NRRAVRDFHD SRKRLEPSGQ SQSQNAGGPN SLPAISAQAA LMYDAVFVLV EAFNRILRKK PDQFRSNHLQ RRSHGGSSSS SATGTNESSA LLDCNTSKGW VTPWEQGEKI SRVLRKVEID GLSGEIRFDE DGRRINYTLH VVEMSVNSTL QQVAEWRDDA GLLPLHSHNY ASSSRSASAS TGDYDRNHTY IVSSLLEEPY LSLKQYTYGE SLVGNDRFEG YCKDLADMLA AQLGIKYEIR LVQDGNYGAE NQYAPGGWDG MVGELIRKEA DIAISAMTIT AERERVIDFS KPFMTLGISI MIKKPVKQTP GVFSFLNPLS QEIWISVILS YVGVSFVLYF VTRFPPYEWR IVRRPQADST AQQPPGIIGG ATLSEPQAHV PPVPPNEFTM LNSFWYSLAA FMQQGCDITP PSIAGRIAAA VWWFFTIILI SSYTANLAAF LTVERMVAPI KTPEDLTMQT DVNYGTLLYG STWEFFRRSQ IGLHNKMWEY MNANQHHSVH TYDEGIRRVR QSKGKYALLV ESPKNEYVNA RPPCDTMKVG RNIDTKGFGV ATPIGSPLRK RLNEAVLTLK ENGELLRIRN KWWFDKTECN LDQETSTPNE LSLSNVAGIY YILIGGLLLA VIVAIMEFFC RNKTPQLKSP GSNGSAGGVP GMLASSTYQR DSLSDAIMHS QAKLAMQASS EYDERLVGVE LASNVRYQYS M //