ID GLK1_DROME STANDARD; PRT; 991 AA. AC Q03445; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-MAR-2004 (Rel. 43, Last annotation update) DE Glutamate receptor I precursor (dGLUR-I) (Kainate-selective DE glutamate receptor). GN GLU-RI. OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93066263; PubMed=1359540; RA Ultsch A., Schuster C.M., Laube B., Schloss P., Schmitt B., Betz H.; RT "Glutamate receptors of Drosophila melanogaster: cloning of a RT kainate-selective subunit expressed in the central nervous system."; RL Proc. Natl. Acad. Sci. U.S.A. 89:10484-10488(1992). CC -!- FUNCTION: L-glutamate acts as an excitatory neurotransmitter at CC many synapses in the central nervous system. The postsynaptic CC actions of Glu are mediated by a variety of receptors that are CC named according to their selective agonists (By similarity). CC -!- SUBUNIT: FORMS HOMOOLIGOMERIC CHANNELS WHICH ARE ACTIVATED BY CC KAINATE. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Central nervous system. CC -!- DEVELOPMENTAL STAGE: No expression is seen in early embryogenesis, CC whereas high expression occurs in late embryos. During larval CC development, expression decreases to undetectable levels in late CC larvae, resumes at the early pupal stage and gradually increases CC in late pupae and early adult flies. High levels of expression CC coincide with major stages of neurogenesis. CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M97192; AAA28575.1; -. DR HSSP; P19491; 1GR2. DR FlyBase; FBgn0004619; Glu-RI. DR GO; GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole ...; IDA. DR InterPro; IPR001828; ANF_receptor. DR InterPro; IPR001320; Ion_glu_receptor. DR InterPro; IPR001622; K+channel_pore. DR InterPro; IPR001311; SBP/glu_receptor. DR Pfam; PF01094; ANF_receptor; 1. DR Pfam; PF00060; lig_chan; 1. DR SMART; SM00079; PBPe; 1. KW Receptor; Postsynaptic membrane; Ionic channel; Transmembrane; KW Signal; Glycoprotein. FT SIGNAL 1 27 Potential. FT CHAIN 28 991 Glutamate receptor I. FT DOMAIN 28 611 Extracellular (Potential). FT TRANSMEM 612 632 Potential. FT TRANSMEM 711 731 Potential. FT TRANSMEM 896 916 Potential. FT DOMAIN 28 32 Poly-Gln. FT DOMAIN 367 371 Poly-Ser. FT CARBOHYD 67 67 N-linked (GlcNAc...) (Potential). FT CARBOHYD 195 195 N-linked (GlcNAc...) (Potential). FT CARBOHYD 208 208 N-linked (GlcNAc...) (Potential). FT CARBOHYD 281 281 N-linked (GlcNAc...) (Potential). FT CARBOHYD 376 376 N-linked (GlcNAc...) (Potential). FT CARBOHYD 385 385 N-linked (GlcNAc...) (Potential). FT CARBOHYD 426 426 N-linked (GlcNAc...) (Potential). FT CARBOHYD 437 437 N-linked (GlcNAc...) (Potential). FT CARBOHYD 477 477 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 991 AA; 111655 MW; F81D5D6D614D0D2C CRC64; MHSRLKFLAY LHFICASSIF WPEFSSAQQQ QQTVSLTEKI PLGAIFEQGT DDVQSAFKYA LLNHNLNVSS RRFELQAYVD VINTADAFKL SRLICNQFSR GVYSMLGAVS PDSFDTLHSY SNTFQMPFVT PWFPEKVLAP SSGLLDFAIS MRPDYHQAII DTIQYYGWQS IIYLYDSHDG LLRLQQIYQE LKPGNETFRV QMVKRIANVT MAIEFLHTLE DLGRFSKKRI VLDCPAEMAK EIIVQHVRDI KLGRRTYHYL LSGLVMDNHW PSDVVEFGAI NITGFRIVDS NRRAVRDFHD NRKRLEPSAK AKARTQGGPN SLPPISAQAA LMYDAVFVLV EAFNRILRKK PDQFRSNHLQ RRSHGGSSSS SATGTNESSA LLDCNTSKGW VTPWEQGEKI SRVLRKVEID GLSGEIRFDE DGRRINYTLH VVEMSVNSTL QQVAEWRDDA GLLPLHSHNY ASSSRSASAS TGDYDRNHTY IVSSLLEEPY LSLKQYTYGE SLVGNDRFEG YCKDLADMLA AQLGIKYEIR LVQDGNYGAE NQYAPGGWDG MVGELIRKEA DIAISAMTIT AERERVIDFS KPFMTLGISI MIKKPVKQTP GVFSFLNPLS QEIWISVILS YVGVSFVLYF VTRFPPYEWR IVRRPQADST AQQPPGIIGG ATLSEPQAHV PPVPPNEFTM LNSFWYSLAA FMQQGCDITP PSIAGRIAAA VWWFFTIILI SSYTANLAAF LTVERMVAPI KTPEDLAMQT DVNYGTLLHG STWEFFRRSQ IGLHNKMWEY MNANQHHSVH TYDEGIRRVR QSKGKYALLV ESPKNEYVNA RPPCDTMKVG RNIDTKGFGV ATPIGSPLRK RLNEAVLTLK ENGELLRIRN KWWFDKTECN LDQETSTPNE LSLSNVAGIY YILIGGLLLA VIVAIVEFFC RNKTPQLKSP GSNGSAGGVP GMLGSSTYQR DSLSDAIMHS QAKLAMQASS EYDERLVGVE LASNVRYQYS M //