ID Q03445 PRELIMINARY; PRT; 991 AA. AC Q03445; DT 01-NOV-1996 (TREMBLREL. 01, CREATED) DT 01-NOV-1996 (TREMBLREL. 01, LAST SEQUENCE UPDATE) DT 01-FEB-1997 (TREMBLREL. 02, LAST ANNOTATION UPDATE) DE GLUTAMATE RECEPTOR PRECURSOR (KAINATE-SELECTIVE) (DGLUR-I PROTEIN). OS DROSOPHILA MELANOGASTER (FRUIT FLY). OC EUKARYOTA; METAZOA; ARTHROPODA; INSECTA; DIPTERA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 93066263. RA ULTSCH A., SCHUSTER C.M., LAUBE B., SCHLOSS P., SCHMITT B., RA BETZ H.; RL PROC. NATL. ACAD. SCI. U.S.A. 89:10484-10488(1992). CC -!- FUNCTION: L-GLUTAMATE ACTS AS AN EXCITATORY NEUROTRANSMITTER AT CC MANY SYNAPSES IN THE CENTRAL NERVOUS SYSTEM. THE POSTSYNAPTIC CC ACTIONS OF GLU ARE MEDIATED BY A VARIETY OF RECEPTORS THAT ARE CC NAMED ACCORDING TO THEIR SELECTIVE AGONISTS. CC -!- TISSUE SPECIFICITY: CENTRAL NERVOUS SYSTEM. CC -!- DEVELOPMENTAL STAGE: THE PROTEIN IS NOT EXPRESSED IN EARLY CC EMBRYOGENESIS. HIGH EXPRESSION OCCURS IN LATE EMBRYOS. DURING CC LARVAL DEVELOPMENT, EXPRESSION DECREASES TO UNDETECTABLE LEVELS CC IN LATE LARVAE, RESUMES AT THE EARLY PUPAL STAGE AND GRADUALLY CC INCREASES IN LATE PUPAE AND EARLY ADULT FLIES. HIGH LEVELS OF CC EXPRESSION COINCIDE WITH MAJOR STAGES OF NEUROGENESIS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M97192; G157511; -. DR FLYBASE; FBGN0004619; GLU-RI. KW RECEPTOR; POSTSYNAPTIC MEMBRANE; IONIC CHANNEL; TRANSMEMBRANE; KW SIGNAL. FT SIGNAL 1 27 POTENTIAL. FT CHAIN 28 991 GLUTAMATE RECEPTOR. FT TRANSMEM 613 632 POTENTIAL. FT TRANSMEM 678 692 POTENTIAL. FT TRANSMEM 707 725 POTENTIAL. FT TRANSMEM 896 916 POTENTIAL. SQ SEQUENCE 991 AA; 111655 MW; 9F113418 CRC32; MHSRLKFLAY LHFICASSIF WPEFSSAQQQ QQTVSLTEKI PLGAIFEQGT DDVQSAFKYA LLNHNLNVSS RRFELQAYVD VINTADAFKL SRLICNQFSR GVYSMLGAVS PDSFDTLHSY SNTFQMPFVT PWFPEKVLAP SSGLLDFAIS MRPDYHQAII DTIQYYGWQS IIYLYDSHDG LLRLQQIYQE LKPGNETFRV QMVKRIANVT MAIEFLHTLE DLGRFSKKRI VLDCPAEMAK EIIVQHVRDI KLGRRTYHYL LSGLVMDNHW PSDVVEFGAI NITGFRIVDS NRRAVRDFHD NRKRLEPSAK AKARTQGGPN SLPPISAQAA LMYDAVFVLV EAFNRILRKK PDQFRSNHLQ RRSHGGSSSS SATGTNESSA LLDCNTSKGW VTPWEQGEKI SRVLRKVEID GLSGEIRFDE DGRRINYTLH VVEMSVNSTL QQVAEWRDDA GLLPLHSHNY ASSSRSASAS TGDYDRNHTY IVSSLLEEPY LSLKQYTYGE SLVGNDRFEG YCKDLADMLA AQLGIKYEIR LVQDGNYGAE NQYAPGGWDG MVGELIRKEA DIAISAMTIT AERERVIDFS KPFMTLGISI MIKKPVKQTP GVFSFLNPLS QEIWISVILS YVGVSFVLYF VTRFPPYEWR IVRRPQADST AQQPPGIIGG ATLSEPQAHV PPVPPNEFTM LNSFWYSLAA FMQQGCDITP PSIAGRIAAA VWWFFTIILI SSYTANLAAF LTVERMVAPI KTPEDLAMQT DVNYGTLLHG STWEFFRRSQ IGLHNKMWEY MNANQHHSVH TYDEGIRRVR QSKGKYALLV ESPKNEYVNA RPPCDTMKVG RNIDTKGFGV ATPIGSPLRK RLNEAVLTLK ENGELLRIRN KWWFDKTECN LDQETSTPNE LSLSNVAGIY YILIGGLLLA VIVAIVEFFC RNKTPQLKSP GSNGSAGGVP GMLGSSTYQR DSLSDAIMHS QAKLAMQASS EYDERLVGVE LASNVRYQYS M //