ID   TGR3_HUMAN     STANDARD;      PRT;   849 AA.
AC   Q03167;
DT   01-FEB-1994 (Rel. 28, Created)
DT   01-FEB-1994 (Rel. 28, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   TGF-beta receptor type III precursor (TGFR-3) (Betaglycan).
GN   Name=TGFBR3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Placenta;
RX   MEDLINE=93080582; PubMed=1333192;
RA   Moren A., Ichijo H., Miyazono K.;
RT   "Molecular cloning and characterization of the human and porcine
RT   transforming growth factor-beta type III receptors.";
RL   Biochem. Biophys. Res. Commun. 189:356-362(1992).
CC   -!- FUNCTION: Binds to TGF-beta. Could be involved in capturing and
CC       retaining TGF-beta for presentation to the signaling receptors.
CC   -!- SUBCELLULAR LOCATION: Exists both as a membrane-bound form and as
CC       soluble form in serum and in the extracellular matrix.
CC   -!- PTM: Extensively modified by glycosaminoglycan groups (GAG).
CC   -!- SIMILARITY: Contains 1 ZP domain.
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DR   EMBL; L07594; AAA67061.1; -.
DR   PIR; JC1350; JC1350.
DR   Genew; HGNC:11774; TGFBR3.
DR   MIM; 600742; -.
DR   GO; GO:0016021; C:integral to membrane; TAS.
DR   GO; GO:0005539; F:glycosaminoglycan binding; TAS.
DR   GO; GO:0007275; P:development; TAS.
DR   GO; GO:0007165; P:signal transduction; NAS.
DR   GO; GO:0007179; P:transforming growth factor beta receptor si...; TAS.
DR   InterPro; IPR001507; Endoglin/CD105.
DR   InterPro; IPR008983; TNF_like.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   PRINTS; PR00023; ZPELLUCIDA.
DR   SMART; SM00241; ZP; 1.
DR   PROSITE; PS00682; ZP_1; 1.
DR   PROSITE; PS51034; ZP_2; 1.
KW   Glycoprotein; Polymorphism; Proteoglycan; Receptor; Signal;
KW   Transmembrane.
FT   SIGNAL        1     16
FT   CHAIN        17    849       TGF-beta receptor type III.
FT   DOMAIN      453    728       ZP.
FT   TRANSMEM    782    807       Potential.
FT   CARBOHYD    140    140       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    490    490       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    532    532       O-linked (Xyl...) (glycosaminoglycan)
FT                                (Potential).
FT   CARBOHYD    543    543       O-linked (Xyl...) (glycosaminoglycan)
FT                                (Potential).
FT   CARBOHYD    569    569       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    588    588       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    695    695       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    828    828       N-linked (GlcNAc...) (Potential).
FT   VARIANT      15     15       F -> S (in dbSNP:1805110).
FT                                /FTId=VAR_014920.
FT   VARIANT      72     72       R -> H (in dbSNP:1805111).
FT                                /FTId=VAR_014921.
SQ   SEQUENCE   849 AA;  93385 MW;  312D2D7E285392AD CRC64;
     MTSHYVIAIF ALMSFCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL
     PQEVHVLNLA LRQGPGQLQR EVTLHLNPIS SVHIHHKSVV FLLNSPHPLV WHLKTERLAT
     GVSRLFLVSE GSVVQFSSAN FSLTAETEER NFPHGNEHLL NWARKEYGAV TSFTELKIAR
     NIYIKVGEDQ VFPPKCNIGK NFLSLNYLAE YLQPKAAEGC VMSSQPQNEE VHIIELITPN
     SNPYSAFQVD ITIDIRPSQE DLEVVKNLIL ILKCKKSVNW VIKSFDVKGS LKIIAPNSIG
     FGKESERSMT MTKSIRDDIP STQGNLVKWA LDNGYSPITS YTMAPVAIVF HLRLENNEEM
     GDEEVHTIPP ELRILLDPGA LPALQNPPIR GGEGQNGGLP FPFPDISRRV WNEEGEDGLP
     RPKDPVIPSI QLFPGLREPE EVQGSVDIAL SVKCDNEKMI VAVEKDSFQA SGYSGMDVTL
     LDPTCKAKMN GTHFVLESPL NGCGTRPRWS ALDGVVYYNS IVIQVPALGD SSGWPDGYED
     LESGDNGFPG DMDEGDASLF TRPEIVVFNC SLQQVRNPSS FQEQPHGNIT FNMELYNTDL
     FLVPSQGVFS VPENGHVYVE VSVTKAEQEL GFAIQTCFIS PYSNPDRMSH YTIIENICPK
     DESVKFYSPK RVHFPIPQAD MDKKRFSFVF KPVFNTSLLF LQCELTLCTK MEKHPQKLPK
     CVPPDEACTS LDASIIWAMM QNKKTFTKPL AVIHHEAESK EKGPSMKEPN PISPPIFHGL
     DTLTVMGIAF AAFVIGALLT GALWYIYSHT GETAGRQQVP TSPPASENSS AAHSIGSTQS
     TPCSSSSTA
//