ID A1AT_DIDMA STANDARD; PRT; 410 AA. AC Q03044; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 01-FEB-1994 (Rel. 28, Last annotation update) DE ALPHA-1-ANTIPROTEINASE PRECURSOR (ALPHA-1-ANTITRYPSIN) (ALPHA-1- DE PROTEINASE INHIBITOR). OS Didelphis marsupialis virginiana (North American opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Didelphis. OX NCBI_TaxID=9267; RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 22-37 AND 127-146. RC TISSUE=Liver; RX MEDLINE=93136143; PubMed=8422360; RA Catanese J.J., Kress L.F.; RT "Opossum serum alpha 1-proteinase inhibitor: purification, linear RT sequence, and resistance to inactivation by rattlesnake venom RT metalloproteinases."; RL Biochemistry 32:509-515(1993). CC -!- FUNCTION: INHIBITOR OF SERINE PROTEASES. THE PRIMARY TARGET IS CC ELASTASE, BUT ALSO HAS A MODERATE AFFINITY FOR PLASMIN AND CC THROMBIN. CC -!- SUBCELLULAR LOCATION: EXTRACELLULAR. CC -!- TISSUE SPECIFICITY: PLASMA. CC -!- SIMILARITY: BELONGS TO THE SERPIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z18906; CAA79343.1; -. DR EMBL; L06824; AAC02630.1; -. DR PIR; A45457; A45457. DR PIR; S29943; S29943. DR HSSP; P01009; 8API. DR InterPro; IPR000215; -. DR Pfam; PF00079; serpin; 1. DR PROSITE; PS00284; SERPIN; FALSE_NEG. KW Serpin; Serine protease inhibitor; Glycoprotein; Plasma; Signal. FT SIGNAL 1 21 FT CHAIN 22 410 ALPHA-1-ANTIPROTEINASE. FT ACT_SITE 374 375 REACTIVE BOND (BY SIMILARITY). FT CARBOHYD 63 63 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 100 100 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 264 264 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 410 AA; 46441 MW; 2A6718C1B2FAA389 CRC64; MMPSTLSLCL MLAGLCSLVT SHLTEEIQAS NDTENEYSST RRISPYMTDF SIDFYRLLVS KSNTTNIFFS PISIYTAFTL LALGAKSATR DQILTGLRFN RTEISEEHIF EGFQQLLNTF NLPENELQLT TSNGLFIDKN LKLVAKFLED SKRLYASDTF STNFEDNMAA KKQINDYVEK ETQGKIVDLI QNLDSNVVFV LVNCIFFKGK WEKPFMTELT TECPFHVDSK TTVPVQTMRR LGMFNVFYDQ DLSCWVLKMK YMGNATALFI LPDTGKIEKV ENALNKMLFH KWTRNLKRRA ISLYFPKVSI SGNYDLKILR ELGITDVFGS NADLSGITEE TNLKLSQAVH KAVVNIDEKG TEASGATFAE GIPMSIPPTV EFLRPFIFII LEENTKSVLF MGKVMNPTGN //