ID   LYAT_BACSU              Reviewed;         306 AA.
AC   Q02115;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-APR-2013, entry version 95.
DE   RecName: Full=Transcriptional regulator LytR;
DE   AltName: Full=Membrane-bound protein LytR;
GN   Name=lytR; OrderedLocusNames=BSU35650;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION AS A TRANSCRIPTIONAL
RP   REGULATOR, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168;
RX   PubMed=1357079;
RA   Lazarevic V., Margot P., Soldo B., Karamata D.;
RT   "Sequencing and analysis of the Bacillus subtilis lytRABC divergon: a
RT   regulatory unit encompassing the structural genes of the N-
RT   acetylmuramoyl-L-alanine amidase and its modifier.";
RL   J. Gen. Microbiol. 138:1949-1961(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 257-306.
RC   STRAIN=168;
RX   PubMed=8126437;
RA   Soldo B., Lazarevic V., Margot P., Karamata D.;
RT   "Sequencing and analysis of the divergon comprising gtaB, the
RT   structural gene of UDP-glucose pyrophosphorylase of Bacillus subtilis
RT   168.";
RL   J. Gen. Microbiol. 139:3185-3195(1993).
CC   -!- FUNCTION: Plays an attenuator role for both its own and lytABC
CC       operon expression, and thus regulates the expression of the major
CC       autolytic amidase of B.subtilis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane
CC       protein (Potential).
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene display a
CC       considerably increased transcription frequency of lytR and lytABC
CC       operon expression.
CC   -!- SIMILARITY: Belongs to the LytR/CpsA/Psr regulatory protein
CC       family.
CC   -!- CAUTION: This protein is unrelated to LytR from S.aureus, which is
CC       part of a two-component regulatory system that, together with
CC       LytS, is involved in autolysis and cell wall metabolism. The
CC       B.subtilis ortholog of S.aureus LytR is LytT (AC P94514).
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DR   EMBL; M87645; AAA22578.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15582.1; -; Genomic_DNA.
DR   EMBL; Z22516; CAA80239.1; -; Genomic_DNA.
DR   PIR; A47679; A47679.
DR   RefSeq; NP_391445.1; NC_000964.3.
DR   ProteinModelPortal; Q02115; -.
DR   SMR; Q02115; 63-305.
DR   STRING; 224308.BSU35650; -.
DR   PaxDb; Q02115; -.
DR   DNASU; 936787; -.
DR   EnsemblBacteria; CAB15582; CAB15582; BSU35650.
DR   GeneID; 936787; -.
DR   GenomeReviews; AL009126_GR; BSU35650.
DR   KEGG; bsu:BSU35650; -.
DR   PATRIC; 18979140; VBIBacSub10457_3732.
DR   GenoList; BSU35650; -.
DR   eggNOG; COG1316; -.
DR   HOGENOM; HOG000236372; -.
DR   OMA; RINNIYY; -.
DR   ProtClustDB; PRK09379; -.
DR   BioCyc; BSUB:BSU35650-MONOMER; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:HAMAP.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   HAMAP; MF_01140; LytR; 1; -.
DR   InterPro; IPR004474; LytR_CpsA_psr.
DR   InterPro; IPR023734; Tscrpt_reg_LytR.
DR   Pfam; PF03816; LytR_cpsA_psr; 1.
DR   TIGRFAMs; TIGR00350; lytR_cpsA_psr; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Membrane; Reference proteome;
KW   Repressor; Signal-anchor; Transcription; Transcription regulation;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    306       Transcriptional regulator LytR.
FT                                /FTId=PRO_0000218498.
FT   TOPO_DOM      1     11       Cytoplasmic (Potential).
FT   TRANSMEM     12     32       Helical; Signal-anchor for type II
FT                                membrane protein; (Potential).
FT   TOPO_DOM     33    306       Extracellular (Potential).
SQ   SEQUENCE   306 AA;  34586 MW;  E79BE5DDFFA3B089 CRC64;
     MRNERRKKKK TLLLTILTII GLLVLGTGGY AYYLWHKAAS TVASIHESID KSKKRDKEVS
     INKKDPFSVL IMGVDERDGD KGRADTLIYM TVNPKTNTTD MVSIPRDTYT KIIGKGTMDK
     INHSYAFGGT QMTVDTVENF LDVPVDYFVK VNMESFRDVV DTLGGITVNS TFAFSYDGYS
     FGKGEITLNG KEALAYTRMR KEDPRGDFGR QDRQRQVIQG IINKGANISS ITKFGDMFKV
     VENNVKTNLT FDNMWDIQSD YKGARKHIKQ HELKGTGTKI NGIYYYQADE SALSDITKEL
     KESLEK
//