ID   CYAA_NEUCR     STANDARD;      PRT;  2300 AA.
AC   Q01631;
DT   01-JUL-1993 (Rel. 26, Created)
DT   01-JUL-1993 (Rel. 26, Last sequence update)
DT   01-FEB-1996 (Rel. 33, Last annotation update)
DE   ADENYLATE CYCLASE (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE) (ADENYLYL
DE   CYCLASE).
GN   CR-1 OR NAC.
OS   Neurospora crassa.
OC   Eukaryota; Fungi; Ascomycota; Euascomycetes; Pyrenomycetes;
OC   Sordariales; Sordariaceae; Neurospora.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 92000795.
RA   KORE-EDA S., MURAYAMA T., UNO I.;
RT   "Isolation and characterization of the adenylate cyclase structural
RT   gene of Neurospora crassa.";
RL   Jpn. J. Genet. 66:317-334(1991).
CC   -!- FUNCTION: PLAYS ESSENTIAL ROLES IN REGULATION OF CELLULAR
CC       METABOLISM BY CATALYSING THE SYNTHESIS OF A SECOND MESSENGER,
CC       CAMP.
CC   -!- CATALYTIC ACTIVITY: ATP = 3',5'-CYCLIC AMP + PYROPHOSPHATE.
CC   -!- SIMILARITY: THE REPEATED LEUCINE-RICH (LRR) SEGMENT IS FOUND IN
CC       MANY PROTEINS.
CC   -!- SIMILARITY: BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.
CC   -!- SIMILARITY: CONTAINS A PP2C-LIKE DOMAIN.
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DR   EMBL; D00909; BAA00755.1; -.
DR   PFAM; PF00211; guanylate_cyc; 2.
DR   PFAM; PF00481; PP2C; 1.
DR   PFAM; PF00560; LRR; 13.
KW   Lyase; Repeat; Leucine-repeat; cAMP synthesis; Magnesium.
FT   DOMAIN       49     52       POLY-SER.
FT   DOMAIN      204    221       POLY-GLN.
FT   DOMAIN     1564   1829       PP2C-LIKE.
FT   DOMAIN     1830   2300       CATALYTIC.
SQ   SEQUENCE   2300 AA;  254752 MW;  FFC20129 CRC32;
     MTRNDGGSRY SSIDSAQSSI TAKPFPLTPT SSLGSSMTRP LSPSLQAGSS SSNGGHNVSR
     SASQGARRPA PTRLKTDDGT QFASRSSRDF ESSQSQSQPS HTQTRSHSLS QATLQSCSQP
     QLSLNSQQSQ SPSQYHSQQT PTQQQPQQQV SPTGGSRLTQ SPTTPSNASI REHRMSELGG
     YRREMAAMLD TTGGALSRTS SHSQQQPQQP QQQQQQQQQQ QGHAAGSVSG TFSNLSQYAP
     YLGGNNGGGM SMGSFLNDST DNLSVISQLS PGIRPMTARP SQASAGSMEF PDSAYYDDER
     RPSIASITTT ASSQGSRTSK TRGGLQKLQQ FFGDRDDWPG RDSSEISLPQ PSHSGPMSTG
     KEHRSHSYSL PGSGRSHRDR NYSNATDHHP STFGSVSTVG GRDRDASPVP SRPRTPVPAP
     EVVPFLYQEA DDIARYGEAP VRTSLTGPDR DRYIDSSQNP PKTSSSARSG HSIVHLPGHH
     KHNKSNEDPR ALKPSLSRED SAASFARDFR NGSSSMMGTR SRAQSPAPSW TGTSRGLKAN
     SISDGTSSPA PSHKKGILGR FRRHNKDKED GSSLRSGSNH TLVHRPSRQD LTRAAESTYP
     ASVYVSDPSE QREVPVRPGY VRQTTAPGFT TKLFTSKKSS SAKQPQDDMD EDIGPTDMHM
     GGGTVYHLDT NLNDMEGILT KPQPMTPLDN SISMRRESEK MIVPITTDPE GAWAAPDSWA
     VRDNKKSLAP QVNEDLCSRQ PSEEKEKKSN YYIRVFRSDS TWTTLTLPLT ATAEDVIMGV
     AKKTYLPPGA QDSYSLLIKK HDLFRVLNSA EQPLRIQKRL FQQIGYQEKD GIDEIGREDN
     SYICRWVFLK EKEADMHLLS PDINFRNQKL NHVDLSGRNL ITIPVPLYRK AAEIVSLNLS
     RNLSLDVPRD FIQACTALRD IKYNNNEAQA LPKSFATASK LTYLDVSNNR LQDLDHSELS
     KLTGLLKVNL ANNCLRSLPP TLGAYKSLRT LNISSNFLDV FPSFICELET IVDLDLSFNS
     INNLPDNLMK LRNLEKFVIT NNRLSGPISE SVRDLVSLRE LDIRYNQIST IDVLSDLPRL
     EILSADHNQI SKFSGSFERL RSLKLNSNPI VKFEVKAPVP IPQILNLSNA QLASIDESID
     NLMNLERLIL DSNYFVSLPN QIGNLKKLDH LSMANNHLGE LPPEIGCLTE LRTLDVHGNN
     MRKLPNEIWW ANKLEHLNAS SNILTEFPKP ASRAPQAPGE ASPSPGAYPF PNANKNGLLS
     RTPSMDDLNG DASRRPSQAS STLLGVAVSP VPSGPDNRKS SMVSLYGKGG RKTSVVSRST
     TQSSTGVITP SNGPRKDSSL SYRFTHTFSG SLKNLYLADN QLDDDVFEEL KHLPELRVLN
     LSCNDLSDMP QGTIRSWPQL VELYLSGNEL TSLPAEDFLE EHCLLQTLHI NGNKFINLPA
     EISRAKKLQV LDCSSNNLKY NVTNVPYDWN WNFNRDLRYL NLSGNKRLEI KNNYRQPQSY
     RDDDFADTDF SKLTNLRVLG LMEVTHTLPN IPDQTEDRRV RTSEMKAGAY LPYGMADTLG
     KNEHLSLFDL VVPRLGSVET DTLVALFDGK ELSTGGSKIA KFLYEEFSRL FILELEKVKG
     KPNENPADAL RRTFLSVNKL LMSLSNSADE RGLDSHPSRN YAHTVLTKED LNSGCVATVA
     YLSELKLYVA NVGDVQGMLI QANGSFKMLT KKHDPADPVE RSRIRNAGGW VSRNGRLNDV
     LNVSRAFGYT ELLPAVQAAP DITEHTIDDK DETVLIASKE LWEHLRPELI VDVARECRSD
     LMKASQKLRD LAIAYGSTNK LLIMMIGVAN LKQRQAQQFK GQLNATFSMP QDDPSHVPPS
     GNKRRKVRAE GPLDSNLMRL NAEVPPPTGQ LSIVFTDIKN STQLWENYPE AMRLAIKLHN
     EVMRRQLRMI GGFEVKTEGD AFMVSFPTAT SALLWCFAVQ MKLLTVDWPP EVLSNSSCQP
     IYDRNNNLIT RGLSVRMGAH WGEPLAERDP VTRRMDYYGP MVNKASRISA VADGGQITAS
     SDFITEIHRC LETYKESVDV DEDSLEDDAT AKAIRAELRA LSSQGFEVKD MGEKKLKGLE
     NPELVYSVYP HALVGRTEQH HAHTESTQNQ AALQPYGALA TPKPATMDPD SEIQFEPETI
     WALWRVALRL EMLCSTLEEP NARGLQAPET ELLERMKQRA GEVTDHFLLN FMEHQISRIE
     TCITSLAVRH IAIGSGPITK LNDLRAPMND VLSTLKEQMD ELARYKAKYG SLDQAETDDA
     TDNNSSGDVD TLDGSDTEQE
//